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Biomedical subjects

M Jogeix

Publications and source records attributed to M Jogeix.

4 recordsLinked to original sources
PubMed1993

Diagnostic screen for assessment of the IHS criteria for migraine by general practitioners.

This study examines the sensitivity and specificity of a self-report screen for the diagnosis of migraine according to the IHS criteria in a sample of 1049 employees of the French National Railways. The diagnosis of migraine derived from the self-report instrument was compared to an unstructured diagnostic interview conducted by a neurologist specialized in the diagnosis and treatment of headache. The sensitivity of the diagnostic screen was poor, but the specificity was excellent. Optimal cut-off points for the questionnaire were determined by the Receiver Operator Characteristics (ROC) method. Assessment of the specific IHS criteria for migraine revealed that the following criteria failed to discriminate subjects with migraine from non-cases: "aggravation by physical activity" and "photophobia and phonophobia". Implications of the findings for modification of the IHS criteria were discussed.

Adult↗
PubMed1984

[Efficacy of sodium valproate in partial epilepsy. Crossed study of valproate and carbamazepine].

An open response-conditional cross-over study of valproate versus carbamazepine has been done in previously untreated patients with partial seizures. Thirty-one patients entered the study. Nineteen were followed up to one year. It appeared that valproate was at least as effective as carbamazepine: at one year, 11 patients were seizure-free on valproate and only 8 were seizure-free on carbamazepine. Furthermore no side-effect was noted in valproate therapy, whereas carbamazepine was stopped in 2 patients because of skin rashes. The efficacy of sodium valproate in partial epilepsy remains controversial. It is of course limited when given as co-therapy in severe epilepsies, uncontrolled with other major antiepileptic drugs. However in naive patients, with recent and previously untreated partial epilepsies, a one-drug treatment with valproate appears to be as effective as carbamazepine or phenytoin. It has less unwanted side-effects and should be prescribed as first line treatment.

Adolescent↗
PubMed1977

[Value of anticonvulsant level determination in the treatment of epilepsies].

Phenobarbital and diphenylhydantoin were estimated in treated epileptics. An initial measurement was made in 457 patients. 96% were taking phenobarbital and 53% diphenylhydantoin. Only 37% of the phenobarbital levels and 18% of the diphenhlhydantoin levels were in a therapeutic range. Correlations between the levels, the stability of the epilepsy and signs of overdosage are discussed. Intolerance to phenobarbital reported in some patients, which appears to be real, is not reflected by "normal" or even low blood levels. By contrast, high levels of phenobarbital appear to be well tolerated. Signs of overdosage were quasi-constant when levels of diphenylhydantoin were greater than 15 mg/1. Doses of phenobarbital and of diphenylhydantoin were altered, levels assessed and the clinical condition evaluated in 134 patients. Bringing levels to within the therapeutic range resulted in the disappearance of attacks in 55% of cases for phenobarbital and 30% for diphenylhydantoin. Reduction of doses responsible for excessively high blood concentrations (overdosage) was practically never associated with an increase in the number of attacks. This adjustment is easy for phenobarbital though much more difficult for diphenylhydantoin. In this study, therapeutic levels were 15 to 25 mg/1 for phenobarbital, and 7 to 15 mg/1 for diphenylhydantoin.

Clinical Trials as Topic↗