PubMed Health⌕ Search

Biomedical subjects

M K Ali

Publications and source records attributed to M K Ali.

7 recordsLinked to original sources
PubMed1979

Respiratory failure in cancer patients.

A review of 180 cancer patients requiring mechanical ventilation disclosed that 26% survived to extubation, and 13% and 7% were alive at two and six months, respectively. Mortality was related to several factors individually and the cumulative number of organ systems dysfunctioning in a given patient. Compared with general intensive care patients, those with respiratory failure and neoplastic disease demonstrated a high incidence of drug-induced pulmonary disease, hematologic abnormalities, pneumothorax, and infections with multiple and unusual organisms--all of which alter the approach to management. Although the long-term survival was poor, immediate survival was comparable with that of many groups of patients with respiratory failure.

Adolescent↗
PubMed1979

Electrocardiographic changes after adriamycin chemotherapy.

The electrocardiograms of 146 patients with metastatic carcinoma of the breast were reviewed before, during, and after the patients received Adriamycin (Doxorubicin) chemotherapy (AD). The most significant electrocardiographic change occurred in the amplitude of the QRS voltage. Seven patients developed cardiomyopathy after AD and showed a significant decrease in QRS voltage. This decrease, however, was more severe at the onset of congestive heart failure that at conclusion of Adriamycin. In 35 patients with pleural effusion, there was an inverse relation between the extent of the effusion and the amplitude of QRS voltage in the absence of congestive heart failure. These results indicate that 1) the sudden and relatively severe decrease in QRS voltage with the onset of CHF limits the value of this ECG criterion for predicting early Adriamycin toxicity, and 2) caution should be exercised in the interpretation of QRS voltage changes in patients with significant pleural effusion.

Breast Neoplasms↗
PubMed1978

Acute cardiac toxicity of antineoplastic agents as the first manifestation of pheochromocytoma.

A 47-year-old male with histiocytic lymphoma and no previous history of heart disease developed significant fluctuations of blood pressure, electrocardiographic evidence of myocardial ischemia, and life-threatening arrhythmia after the first dose of BACOP (bleomycin, adriamycin, cyclophosphamide, Oncovin, and prednisone) chemotherapy. The presence of pheochromocytoma was suspected, and it was demonstrated by elevated urinary metanephrines, catecholamines, and vanillylmandelic acid, and finally confirmed on autopsy. The possible role of chemotherapeutic agents in stimulating excessive catecholamine release, thus causing transient cardiac injury, is suggested.

Adrenal Gland Neoplasms↗
PubMed1977

Regional pulmonary function in scimitar syndrome.

Analysis of regional pulmonary function distribution using radioactive 133xenon gas and eight scintillation detectors was performed in a patient with scimitar syndrome. Zonal ventilation per unit of lung volume within the slightly hypoplastic right lung was normal. The pulmonary blood flow to the lower right zone was significantly reduced due to aberrant systemic arterial supply to the right lower lobe. The 133xenon technique provides a simple nontraumatic method of evaluating the functional integrity of the right lung in this cardiopulmonary syndrome.

Adult↗
PubMed1976

Radiation-related myocardial injury. Management of two cases.

Pericardial effusion and trifascicular block developed 5 years following mediastinal irradiation for Hodgkin's disease in a 19-year-old patient. Another 24-year-old patients had an acute myocardial infarction followed by severe angina pectoris 5 years following mediastinal irradiation for the same disease. A pericardial window and a permanent demand pacemaker were used in the first case; an aorto-coronary vein grafting was utilized in the second patient. Both patients responded to treatment and are well. Five other previously reported cases of myocardial injury that occurred 2 months to 8 years following mediastinal irradiation in young patients were reviewed. To our knowledge, successful surgical treatment of this disease entity has not been reported before. Close, long-term follow-up of patients who have received mediastinal irradiation should be helpful in the early recognition and successful management of these serious cardiac complications. The systematic clinical and radiographic surveilance of these patients should be supplemented by a routine 12-lead electrocardiogram.

Adult↗
PubMed1975

Regional pulmonary function before and after pneumonectomy using 133xenon.

Regional pulmonary function studies using 133xenon gas, spirometry, and arterial blood gas levels were performed before and 1 to 47 months after pneumonectomy for bronchogenic carcinoma in 27 patients. The mean loss in forced vital capacity was more after right pneumonectomy (44.9 percent of preoperative value) than after left lung resection (41.4 percent). There was no significant change in regional pulmonary function distribution within the remaining lung in 24 patients. Two patients developed significant changes in regional pulmonary blood flow; one had hepatic cirrhosis, and the other sustained a myocardial infarction after pneumonectomy. The third patient with significant apical hyperperfusion before pneumonectomy gradually developed abnormal distribution of ventilation concomitant with electrocardiographic evidence of cor pulmonale within two years after pneumonectomy. The mean ventilation of the apical zones was significantly lower than the mean of 14 healthy subjects. This finding and the higher incidence of ventilatory defects were related to old age and heavy smoking. Seven patients with marked reduction of pulmonary blood flow to the tumor-bearing lung (9 to 33 percent of cardiac output) had technically successful pneumonectomy. A formula and nomogram were developed to estimate the prognostically significant forced expiratory volume in one second after pneumonectomy from the preoperative studies.

Age Factors↗