A rapid, simple acetaminophen spectrophotometric determination.
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Biomedical subjects
Publications and source records attributed to M K Aravind.
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We describe a "highly-performance" liquid chromatographic method in which 8-chlorotheophylline is used as an internal standard to determine acetaminophen and salicylate simultaneously in plasma samples. Therapeutic as well as toxic concentrations can be determined on samples as small as 50 micro L, which makes the method particularly useful for determinations on samples from young children. The procedure requires a simple extraction of the drugs, and the chromatography is completed in 6 min.
A simplified method for the quantitation of phencyclidine using nitrogen-detection gas chromatography is described. The samples are extracted twice with n-butyl chloride containing benzphetamine as an internal standard. A 0.5 mL sample is required for detection of as little as 5 ng/mL PCP. The assay is easy, fast and reliable. Due to the relatively small volume required, this method is suitable for analysis of pediatric samples.