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M K Bruch

Publications and source records attributed to M K Bruch.

5 recordsLinked to original sources

Regulation of topical antimicrobials: history, status and future perspective.

Antimicrobial agents used as disinfectants and antiseptics are increasing in epidemiologic importance. The regulation of topical antiseptics has ranged from nonexistent, lax and confusing to inclusion in the Food and Drug Administration (FDA) over-the-counter (OTC) review of drug ingredients. This article simplifies the complex history, current status and future possibilities for the hospital use of topical antiseptic products.

Anti-Infective Agents, Local

Regulatory agencies.

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Contact Lenses, Hydrophilic

Dry heat resistance of spores of Bacillus subtilis var. niger on Kapton and Teflon Film at high temperatures.

To determine parameters that would assure sterility of a sealed seam of film for application in "split-seam entry," spores of Bacillus subtilis var. niger were sprayed onto pieces of Kapton and Teflon film. Short-time, high-temperature (200 to 270 C) exposures were made with film pieces between aluminum blocks in a hot-air oven, and the D and z values were determined after subculture of surviving spores. The use of Kapton film allowed the study of high temperatures, since it is not heat sealable and could be used to make thin packages for heat treatment. Spores on Teflon were dry-heat treated in a package designed to simulate an actual seam to be sealed. The z values of 29.1 C (52.4 F) for spores on Kapton and 139 C (250.4 F) for spores on Teflon were calculated.

Bacillus subtilis