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Biomedical subjects

M K Chowdhury

Publications and source records attributed to M K Chowdhury.

At least 19 recordsLinked to original sources
PubMed2006

Urogenital anomalies associated with anorectal malformations in children.

The urogenital tract is the most severe and common site of associated defects in anorectal malformations (ARM). Urogenital anomalies and their complications significantly increase the morbidity in these children after the ARM is corrected. The purpose of this study was to estimate the incidence of different types of urogenital anomalies with various types of anorectal malformations and to discuss the possible management and outcome. A retrospective study of patients with ARM and associated urogenital abnormalities admitted in the department of paediatric surgery of Sylhet MAG Osmani Medical College Hospital between 1998 and 2002 was undertaken. A total of 155 patients with Anorectal malformations were admitted of which 47 (30.32%) patients had associated anomalies involving other systems. Urogenital abnormalities were found in 25 (16.13%) patients. Patients of Anorectal malformations with urogenital abnormalities require careful assessment and well-timed intervention to minimize the morbidity.

Anal Canal↗
PubMed2003

Histological and histochemical study of endometrium in dysfunctional uterine haemorrhage.

Menstrual disorder is one of the most frequently encountered and perplexing conditions in adult women. Dysfunctional uterine haemorrhage (DUH) includes scanty, excessive or irregular bleeding, the primary cause of which is yet to become clear. A total of 100 cases of DUH were studied by histological and histochemical evaluation of endomertium with an object to find out the pathophysiology of DUH. Twenty cases of the similar age group without DUH acted as control. Irregular excessive bleeding was found to be the highest in multiparous women in their 4th decade of life. The material from endometrium was studied by haematoxylin and eosin statin, alcian blue, periodic acid Schiff's reaction and alkaline phosphatase activity. Histological examination of the study group revealed normal endometrium in 66% of cases and abnormal in 34% cases while histochemical behaviour was normal in 54% cases and abnormal in 46% cases. Hormonal imbalance is the chief factor in the pathogenesis of DUH and this abnormal hormonal status can better be revealed by a combined study of histological and histochemical evaluation of endometrium.

Adolescent↗
PubMed2002

Maternal malnutrition, perinatal mortality and foetal pathology--a clinicopathological study.

The close relationship between the maternal malnutrition and consequent birth of low birth weight babies and the perinatal mortality is now an accepted fact and has been studied extensively in developed countries, though the problem is more acute in developing countries. The present study was proposed to find out relationship between the maternal nutritional status and the perinatal mortality. Autopsy was performed on 100 babies dying perinatally and pathological examination of different foetal organs in both well and malnourished mothers was also undertaken. Maternal nutritional status was evaluated by estimating haemoglobin level and total serum protein level. A mother with haemoglobin level below 11 g/dl and/or serum protein level below 5 g/dl was considered as malnourished. Pathological findings in the dead babies included low birth weight (500-1,999g), haemorrhage in multiple organs, atelectasis of the lungs, fatty changes in the liver, cystic changes of the kidneys and ill developed parenchyma of the pituitary.

Adolescent↗
PubMed1999

Calcium channel blockers and mortality in elderly patients with myocardial infarction.

BACKGROUND: Although calcium channel blockers are a useful therapy in relieving angina, lowering blood pressure, and slowing conduction of atrial fibrillation, growing evidence has cast doubt on their safety in patients with coronary disease. OBJECTIVE: To examine the association between calcium channel blocker therapy at hospital discharge and mortality in a population-based sample of elderly patients hospitalized with acute myocardial infarction. DESIGN: Retrospective cohort study using data from medical charts and administrative files. SETTING: All acute care hospitals in 46 states. PATIENTS: All Medicare patients with a principal diagnosis of acute myocardial infarction consecutively discharged from the hospital alive during 8-month periods between 1994 and 1995 (N = 141,041). MAIN OUTCOME MEASURE: Mortality at 30 days and 1 year. RESULTS: Calcium channel blockers were widely prescribed at hospital discharge to elderly patients with myocardial infarction between 1994 and 1995 (n = 51,921), the most commonly prescribed being diltiazem (n = 21,175), nifedipine (n = 12,670), amlodipine (n = 11,683), and verapamil (n = 3639). After adjusting for illness severity and concomitant medication use, patients who were prescribed calcium channel blockers at hospital discharge did not have increased risk for 30-day or 1-year mortality, with the exception of the few (n = 116) treated with bepridil. Bepridil differs from other calcium channel blockers because of its tendency to prolong repolarization, and its association with proarrhythmic effects in elderly patients. CONCLUSION: We did not identify a mortality risk in a large consecutive sample of elderly patients with myocardial infarction, which supports the need for additional prospective trials examining calcium channel blocker therapy for ischemic heart disease.

Aged↗
PubMed1994

Socioeconomic and anthropometric status, and mortality of young children in rural Bangladesh.

This article investigates the interrelationship of socioeconemic status, anthropometric status and mortality of young children in rural Bangladesh. Data for this study come from Matlab, the vital registration area of the International Centre for Diarrhoeal Disease Research, Bangladesh, where anthropometric and socioeconomic data concerning 1976 children aged 12-23 months were collected in November-December 1975. From these data, anthropometric indices are created, and the relationships of socioeconomic status measured by dwelling space and anthropometric indices with mortality during the 2 years following measurement of these children are investigated. It is found that both socioeconomic status and anthropometric indices are related to mortality. However, the relationship of anthropometric indices is much stronger. Among the anthropometric indices considered, weight-for-age, height-for-age and arm circumference reflect socioeconomic status better than weight-for-height does; and, the first three indices are equally good, and individually better than weight-for-height, as predictors of mortality. The degree of the effect of socioeconomic status (dwelling space) on mortality explained by the best performing anthropometric index, weight-for-age, was not more than 25%. It is concluded that an anthropometric index that can classify socioeconomic status more efficiently is a better predictor of 2-year mortality than any other anthropometric index.

Anthropometry↗
PubMed1994

Incidence of malignancy in Bankura (a retrospective study).

A retrospective study on pattern of malignant lesions in a rural district of West Bengal from 1981-1990 was conducted in the department of pathology, BS Medical College, Bankura, West Bengal. A total number of 17,130 cases were received out of which 1976 were malignant lesions (11.53%). The peak incidence of cancer in both sexes was found between the 4th, 5th and 6th decades, ie, 31-60 years of age. Sex-wise distribution showed more incidence in female (1246-62.17%) than in male (730-37.83%). Cancer of the cervix (35.62%) showed the highest incidence in this series. Cancer of the larynx (11.94%) was the commonest cancer in males. Malignancy of the lymph node was observed in 11.43% cases. Malignancy of the lungs and vagina (< 0.5%) showed very low incidence.

Adult↗
PubMed1993

Frusemide-induced diabetes mellitus in insulin pretreated rabbits as an experimental model.

Single dose of frusemide 0.1 mg/kg orally was administered in 10 rabbits pretreated with soluble insulin 4 IU intravenously. Induction of diabetes after 24 h was confirmed by an increase in blood sugar and glucosylated haemoglobin and a decrease in serum insulin levels. Ten diabetic rabbits which received only frusemide without insulin pretreatment were used as controls, whereas equal number of insulin-pretreated rabbits receiving hydrochlorothiazide 250 mg/kg orally served as the positive control group. All biochemical parameters remained unaltered in the frusemide-treated test group as well as the positive control group after two weeks. The pancreatotoxic effect of frusemide may induce a stable hyperglycaemic state in rabbits which could lead to a useful diabetic model.

Administration, Oral↗
PubMed1992

Hepatic lesions caused by excretory and secretory products of Ascaris lumbricoides in golden hamster.

OBJECTIVE: To ascertain the role of excretory and secretory (ES) products of Ascaris lumbricoides in liver damage. METHODS: The ES products of A lumbricoides were collected in vitro and their SDS-PAGE analysis was done. Feeding and subcutaneous injection of ES products were done in hamsters. Estimation of serum proteins, alkaline phosphatase and alanine aminotransferase and histology of liver were carried out. Control animal experiments were done concurrently. RESULTS: The ES products of A lumbricoides contained several proteins ranging in molecular weight from 14 to 205 Kd. Prolonged feeding of ES products caused elevation of ALT and amyloid deposition in the liver, whereas short term feeding or subcutaneous challenge caused focal cell necrosis and granuloma formation in the liver. CONCLUSION: ES products of A lumbricoides can produce liver damage.

Amyloidosis↗
PubMed1990

Sex differences and sustained excess in mortality among discordant twins in Matlab, Bangladesh: 1977-1985.

This paper reports findings from a study that compared survival of 204 pairs of liveborn twins discordant for sex and a random sample of 2371 singleton live births from the same population in Matlab, Bangladesh during the period 1977-1985. The discordant twins showed no evidence of sex differential in neonatal survival. They had neonatal mortality of 287 and infant mortality of 468, both per 1000 live births. These rates were respectively five and four times the rate for singletons in the study. Survival from 12 months through age nine years was similar overall for both discordant twins and singletons for each sex. However, higher female than male mortality was present among discordant twins after the first few months of life. This differential was most prominent during the second year of life and appeared wider than that observed for the singletons.

Bangladesh↗
PubMed1990

Does malnutrition predispose to diarrhoea during childhood? Evidence from a longitudinal study in Matlab, Bangladesh.

It is posited that diarrhoeal illness during one period has influence on diarrhoeal illness in a subsequent period. This relationship may potentially mask the association between malnutrition and subsequent diarrhoea. To test this, we analysed data on cross-sectional anthropometry in combination with data on diarrhoeal morbidity collected longitudinally in a community-based study of 1262 children (aged 6-60 months) during March-December, 1976, in Matlab, Bangladesh. The results confirmed the posited relationship between diarrhoeal morbidities in two consecutive periods and showed that the risks of diarrhoeal attack and longer diarrhoeal illness increased more than threefold during the 2 months following diarrhoeal illness during the preceding 2 months (previous diarrhoea). Children with no previous diarrhoea indicated a positive association between malnutrition and subsequent diarrhoea, but the pattern found among children with previous diarrhoea was not understandable. Logistic regression analyses performed separately for younger and older children showed that controlling for effects of previous diarrhoea, maternal illiteracy and household poverty, severe malnutrition as assessed by weight-for-age was found to be strongly associated with the risk of longer diarrhoeal illness in a 2-month interval in the age group 24-60 months; in the same age group the association with the risk of diarrhoeal attack was significant at the 10 per cent level. No such association for malnutrition, however, was found in the age group 6-23 months.

Bangladesh↗
PubMed1987

The association between malnutrition and diarrhoea in rural Bangladesh.

The interaction between diarrhoeal disease and nutritional status measured by anthropometry was investigated in approximately 1000 children aged 1 to 4 years during April-December 1976 in a rural area of Bangladesh. Data on diarrhoeal disease were provided by the mothers interviewed at seven-day intervals. Weight and height data were collected bimonthly. Children classified using anthropometric criteria--weight-for-age, height-for-age, and weight-for-height--were prospectively evaluated for incidence and duration of diarrhoea during a short (two-month) period and a long (eight-month) period. Incidence of diarrhoea was not found to be related to nutritional status measured by any of the anthropometric criteria for any of the periods. But duration of diarrhoea was found to be related consistently to nutritional status measured by weight-for-age and weight-for-height. Diarrhoea in the short term affected weight increment in the short term, but not in the long term and did not affect height increment for any of these periods. Diarrhoea in the long term affected both weight increment and height increment in the long term.

Anthropometry↗
PubMed1985

Alternative anthropometric indicators of mortality.

The ability of anthropometric indicators, weight-for-age, height-for-age, weight-for-height, weight velocity, and height velocity to discriminate mortality during a one-year period is examined for three time frames beginning in different seasons. Data on approximately 1,000 children of one to four years of age come from the Matlab, International Centre for Diarrhoeal Disease Research, Bangladesh. The indicators' mortality-discriminating power is assessed in terms of the magnitude of difference between the mean indicator values of living and dead children expressed in standard deviation units and of the maximum sum of sensitivity and specificity. The indicators' mortality curve by nutritional status shows the discriminating power visually; the t test indicates its statistical significance. Weight-for-age and height-for-age perform better than weight velocity and height velocity as discriminators of mortality during a one-year period. The ability of weight and height velocity to discriminate short-term mortality is examined by comparing the mean velocity of the last two bimonthly intervals of the dead children. Weight velocity is likely to be a good indicator of short-term mortality.

Anthropometry↗
PubMed1983

Seasonality of classical and El Tor cholera in Dhaka, Bangladesh: 17-year trends.

Data on the cholera patients admitted monthly to the ICDDR, B, hospital in Dhaka (Bangladesh) from 1964 through 1980 have been studied and analysed. Although Vibrio cholerae variant El Tor did not enter Bangladesh until 1963, it has completely displaced classical cholera since 1973. There have also been changes in seasonality, which are discussed.

Bangladesh↗
PubMed1982

On error due to graduation of scaling for anthropometry.

It is shown that the measurement error due to graduation of scaling for anthropometric variables usually follows a uniform distribution. The result is used to investigate to what extent graduation in anthropometric scales affects th short-term intrasubject variance. It is seen that for commonly used graduations the effect is not to be considered substantial.

Anthropometry↗
PubMed1982

Age misstatement for young children in rural Bangladesh.

Age data for 3,393 children, six years of age and under, in rural Bangladesh are analyzed for the level and pattern of age misstatement. Random error, age heaping at whole years, and preferences for particular ages are found in the data. Variation in age reporting is discovered to increase monotonically with age. Systematic errors in age misstatement display modest overstatement for the first four years of life and more pronounced understatement for ages 4, 5, and 6. Age misstatement is examined for its effect on one indicator often used in nutritional surveillance--weight-for-age of children. The impact of the various types of age misstatement (a) increases the difficulty of interpreting weight-for-age and (b) obscures accurate understanding of malnutrition in Bangladeshi children.

Age Factors↗