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Biomedical subjects

M K Foley

Publications and source records attributed to M K Foley.

8 recordsLinked to original sources
PubMed1995

Role of the vagal branches to the proximal stomach in mediating gastric distention-induced disruption of canine interdigestive upper gut motility.

Previous experiments from our laboratory have shown that the vagus nerves mediate proximal gastric distention-induced disruption of interdigestive motor patterns in the upper gut of dogs. Our aim was to determine the role of vagal innervation of the proximal stomach in mediating the response to nonnutrient proximal gastric distention. Five dogs underwent proximal gastric vagotomy (PGV) and placement of electrodes and manometry catheters on the antrum and the upper small intestine. Proximal gastric distention for 5 hr was achieved by inflating a thin, compliant bag in the proximal stomach. Four volumes of distention stimulus (0, 1.5, 12.5, and 25 ml/kg) were tested. As with total abdominal vagotomy, intragastric stimulus volumes of 12.5 and 25 ml/kg after PGV no longer inhibited cycling of the migrating motor complex in the stomach, duodenum, proximal jejunum, and distal jejunum. Volumes of 12.5 and 25 ml/kg did, however, on occasion, lead to the absence of phase III activity in the stomach or the duodenum when it would have been expected to precede phase III activity in the jejunum; this effect did not occur in the jejunum. These findings with a nonnutrient stimulus suggest that vagal branches to the proximal stomach might mediate, in part, the postprandial changes in upper gut motility in response to gastric distention by ingestion of a meal.

Animals↗
PubMed1991

A surgical model for studying biliary bile acid and cholesterol metabolism in swine.

Techniques were developed in young growing pigs to simultaneously collect and reinfuse bile. Silastic cannulae were designed and surgically implanted in the common bile duct and the duodenum. Direct sampling of the hepatic bile was achieved by bypassing the gallbladder. The techniques allowed for steady-state studies of hepatic function to be conducted in conscious swine in two different studies. Pigs, thus surgically modified, can serve as an appropriate model for physiologic, pharmacologic, and nutritional research that involves bile sampling.

Animals↗
PubMed1990

Influence of dietary calcium and cholecalciferol on composition of plasma lipids in young pigs.

Young growing pigs were fed diets containing either 1 or 3 times the daily requirement of calcium and 1, 5 or 25 times the daily requirement of vitamin D (as cholecalciferol) in a completely randomized design with treatments in a 2 X 3 factorial arrangement. Excess dietary calcium increased the phospholipid concentration in the plasma, but not its partitioning among plasma lipoproteins. The level of dietary calcium had no effect on cholesterol, triacylglycerol or protein concentrations in plasma or their partitioning among plasma lipoproteins. Excess dietary calcium decreased body weight gains of pigs. The level of dietary cholecalciferol had no effect on body weight gain or on the concentrations of cholesterol, phospholipid, triacylglycerol or protein in plasma, or on their partitioning among plasma lipoproteins. Increased vitamin D intake resulted in increased plasma 25-hydroxycholecalciferol, whereas high dietary calcium decreased concentrations of 1,25-dihydroxy-vitamin D. Increased dietary calcium also increased plasma calcium concentrations of only plasma phospholipids and decreased growth rate, whereas excess dietary vitamin D had no effect on growth or lipid composition of plasma in growing pigs.

Animals↗
PubMed1990

Effect of dietary fat source on lipoprotein composition and plasma lipid concentrations in pigs.

Most studies of the effects of dietary fat sources on plasma lipid components have used diets with extreme fat compositions; the current study was designed to more nearly mimic human dietary fat intake. Young growing pigs were fed diets containing either 20 or 40% of energy as soy oil, beef tallow or a 50/50 blend of soy oil and tallow. Different dietary fats did not affect concentrations of cholesterol, triacylglycerol or protein in plasma or major lipoprotein fractions. The concentration of phospholipid was less in plasma and in very low density lipoproteins with soy oil feeding than with tallow feeding. The weight percentage of cholesteryl ester in the low density lipoprotein fraction tended to be greater with 40% than with 20% tallow and tended to be less with 40% than with 20% soy oil. Phospholipid as a weight percentage of low density lipoprotein was least in pigs fed soy oil. Tallow feeding increased the percentage of myristic, palmitic, palmitoleic and oleic acids in plasma, relative to both other groups. Soy oil feeding increased the percentage of linoleic and linolenic acids. These moderate diets were not hypercholesterolemic, but they did alter plasma fatty acid composition and phospholipid concentrations in plasma and very low density lipoprotein.

Animals↗
PubMed1989

Children with cancer: ethical dilemmas.

Ethical dilemmas have been called the "dark side of medical progress." However, ethical dilemmas can enlighten health care professionals. Nurses are examining these dilemmas to better resolve similar situations in the future. The role of the pediatric oncology nurse is important in the successful resolution of dilemmas related to the child with cancer. Pediatric oncology nurses are involved in all aspects of the process of informing the child and family about disease, and treatment, and they can encourage communication between the health care team and family. Finally, it is important that nurses keep abreast of landmark legal and ethical decisions affecting children and young adults. The controversy over parental rights v government-imposed choices will continue. "Baby Doe" and religious freedom struggles are two contemporary dilemmas. AIDS will set legal and ethical precedents. The outcome of these arguments will undoubtedly affect the care of the child with cancer.

Adolescent↗
PubMed1986

Interrelationships between serum levels of amiodarone, desethylamiodarone, reverse T3 and the QT interval during long-term amiodarone treatment.

The interrelationships between serum levels of amiodarone, desethylamiodarone, and reverse T3, and changes in the corrected QT interval (delta QTc) were examined in 22 patients during long-term treatment with amiodarone. At 1, 3, and 6 months of follow-up, the correlation coefficient between serum levels of amiodarone or desethylamiodarone and reverse T3 ranged from 0.01 to -0.2 (p greater than 0.4). At the same time intervals, the correlation coefficient between both amiodarone and desethylamiodarone levels and delta QTc ranged from 0.1 to -0.1 (p greater than 0.6), and the correlation coefficient between reverse T3 and delta QTc also ranged between 0.1 to -0.1 (p greater than 0.5). Substituting percent delta QTc for delta QTc also did not reveal a significant correlation. These data demonstrate that serum levels of reverse T3 cannot be used as a substitute for serum levels of amiodarone in monitoring patients being treated with amiodarone. The absence of a correlation between serum reverse T3 levels and delta QTc suggests that the delay in repolarization which occurs during amiodarone therapy is not secondary to an amiodarone-induced abnormality in thyroid hormone metabolism.

Adult↗