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Biomedical subjects

M K Krishnakumari

Publications and source records attributed to M K Krishnakumari.

26 records · Page 2Linked to original sources

Acute oral toxicity of hexachlorocyclohexane and X-factor to poultry Gallus domesticus.

Twelve week old male birds (Gallus domesticus) were intragastrically administered technical grade samples of Benzene hexachloride (gamma-isomer: 13%) and X-factor (gamma-isomer: 16%) [a by-product obtained during separation of gamma-isomer from (BHC)] in capsules with a view of establishing oral LD50 values. The computed oral LD50 values for BHC and X-factor were 596.8 and 589.5 mg/kg body weight, respectively, indicating no variation in their susceptibility to these pesticides. observations on symptoms, feed intake, body weight gain, organ weights, and microscopic examination of vital organs are reported.

Animals↗

Cardiotoxic effects of dichlorvos (DDVP) in albino rats.

Dichlorvos (O, O-dimethyl O-(2,2-dichlorovinyl phosphate: DDVP 76.6 X EC) an organophosphate pesticide had a profound effect on cardiac activity of albino rats. Adult male rats anesthetized with pentobarbitone were administered 30, 50, 70 and 90 mg/kg body weight of dichlorvos. The heart rate and electrocardiogram were monitored and acetylcholinesterase activity was measured in heart and brain. Dichlorvos produced abnormalities in ECG, decrease in heart rate, cardiac arrest and inhibition of cholinesterase activity. It is suggested that cardiotoxic effect of DDVP may be mediated by the accumulated acetylcholine as a result of cholinesterase inhibition.

Animals↗