PubMed Health⌕ Search

Biomedical subjects

M K Lalitha

Publications and source records attributed to M K Lalitha.

At least 73 records · Page 4Linked to original sources
PubMed1991

Non 01 Vibrio cholerae in intestinal and extra intestinal infections in Vellore, S. India.

Non 01 V.cholerae is known to cause gastroenteritis and extra intestinal manifestations, including septicemia. We report here our isolation of non 01 V.cholerae from various clinical specimens. Although most of the isolates are from faeces samples from patients with diarrhoea, we have three isolates from blood culture in patients with underlying liver disease. The highest incidence occurred in 1982-1983 and 1987 and 1988.

Bacteremia↗
PubMed1991

Rapid identification of clinically important bacteroides by coagglutination method.

A coagglutination technique using indigenous reagents was applied for the rapid identification of Bacteroides fragilis and the black pigmented bacteroides group, using colony suspensions. All the 58 strains of B. fragilis and 42 strains of black pigmented bacteroides tested could be correctly identified by this method. The specificity of the coagglutination reagent was confirmed by the absence of cross reactivity with the related species of bacteroides, viz., B. distasonis, B. ovatus, B. vulgatus and B. thetaiotaomicron as well as other anaerobic and aerobic bacteria. A panel of four antisera against B. fragilis was required for correct identification of the strains tested, indicating the presence of multiple serotypes. On the other hand, all 42 strains of black pigmented bacteroides tested could be identified, using a single reagent as these strains appeared to have no antigenic type variants.

Agglutination Tests↗
PubMed1991

Detection of Bacteroides infection by counter immunoelectrophoresis test.

The counterimmunoelectrophoresis (CIE) test using sonicated antigens of Bacteroides fragilis NCTC 2553 and a B. asaccharolyticus strain, standardised in the laboratory yielded a negative result in the 50 normal sera tested, while it was positive in 24 of 34 (71%) patients with infection due to black pigmented bacteroides and in 10 of 15 (67%) with B. fragilis infection. The microagglutination test (MAT) done in parallel showed a positivity of only 44 and 40 per cent respectively. The CIE test done with B. asaccharolyticus antigen was negative in 87 per cent of patients with infection due to B. fragilis whereas MAT showed cross reactivity to a greater extent.

Agglutination Tests↗
PubMed1990

Infective endocarditis due to Streptococcus sanguis I occurring on a normal mitral valve.

We report a 64 year old lady in whom infective endocarditis of the mitral valve occurred with no previous underlying heart disease. Streptococcus sanguis I was isolated on blood culture and 2-D echo cardiography showed a vegetation on the anterior mitral leaflet. The viridans group of streptococci are classically associated with subacute endocarditis occurring on structurally abnormal valves, but involvement of a normal valve by these organisms is rare.

Echocardiography↗
PubMed1990

Susceptibility pattern of bacterial isolates to lomefloxacin.

The in vitro susceptibility pattern with respect to lomefloxacin was determined in case of 1009 bacterial isolates from clinical specimens with varying susceptibility to commonly used antimicrobial agents. The MIC50 and MIC90 values of lomefloxacin for the Gram negative bacilli showed susceptibility value ranging between 0.12 to 4.0 micrograms/ml, while 90 per cent of the streptococci tested were inhibited only at 16 micrograms/ml. Lomefloxacin was comparable in activity to enoxacin and ciprofloxacin but it was more active than norfloxacin and nalidixic acid.

Anti-Infective Agents↗
PubMed1989

Cerebral phaeohyphomycosis caused by Chaetomium globosum in a renal transplant recipient.

A 32-year-old male patient developed headaches, vomiting, blurring of vision, and focal seizures of the left side of the face 2 months after a renal transplant. He developed a brain abscess and died. Direct KOH examination of the brain tissue demonstrated hyaline as well as dematiaceous, septate hyphae. Histologic examination of brain sections revealed polymorphous fungal elements consisting of septate, dark-pigmented hyphae, intercalary and terminal swollen fungal cells, and budding yeastlike cells characteristic of phaeohyphomycosis. Chaetomium globosum was isolated from the brain tissue on all of the fungal media used. This case represents the first histologically and culturally documented phaeohyphomycotic brain infection caused by C. globosum.

Adult↗
PubMed1985

Isolation of Acanthamoeba culbertsoni from a patient with meningitis.

A case of amoebic meningitis, presumably primary, was encountered in the Christian Medical College Hospital, Vellore, South India, in November 1983. The patient, a 40-year-old man, had cerebrospinal fluid rhinorrhea before the meningitis developed. Acanthamoeba culbertsoni was repeatedly demonstrated in and cultured from the cerebrospinal fluid. The patient responded dramatically to a combination therapy of penicillin and chloramphenicol.

Adult↗
PubMed1985

Changes in incidence of shigella subgroups and their antibiotic susceptibility pattern in Vellore, South India.

Investigations were carried out on faecal samples of cases of diarrhoea presenting at a hospital in Vellore, South India, over a period of 1 year. Pathogens were identified and tested for susceptibility to a number of antibiotics. Blood cultures were carried out where septicaemia was suspected. It was found that the relative frequencies of the shigella subgroups have changed since previous reports. The paper reports changing resistance patterns of shigellae to antibiotics and the existence of a number of multiple drug resistant strains. The authors recommend constant surveillance of resistance patterns so that effective therapy can be given in emergency conditions.

Drug Resistance, Microbial↗
PubMed1984

Rapid screening of fecal samples for Vibrio cholerae by a coagglutination technique.

A coagglutination procedure for detecting Vibrio cholerae was applied directly to 125 watery fecal samples received in the laboratory for bacteriological culture: many of these were from suspected cases of cholera. Of 47 bacteriologically proved cases of cholera, 44 (93.6%) gave positive results by the coagglutination method. There was a good correlation between the coagglutination method, dark-field microscopy, and culture.

Agglutination Tests↗