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Biomedical subjects

M K Nedz'ved'

Publications and source records attributed to M K Nedz'ved'.

At least 19 recordsLinked to original sources
PubMed1995

[The characteristics of progressive dementias in patients with herpetic encephalitis].

9 lethal cases of progressive dementias were analysed, both psychical and neurological disturbances characteristics on different stages of herpetic dementias were presented, a number of clinical morphological criteria of diagnosis ascertaining was described. It was determined that progressive dementias turned out to be one of the clinical forms of chronic CNS herpetic infection which was conditioned by prolonged persistence and activation of herpes simplex virus in brain tissue.

Aged↗
PubMed1993

[Chronic herpetic encephalitis with a progressive epileptic syndrome].

Basing on the evidence provided by clinicomorphological and immunobiological studies, three, patients with progressive epileptic seizures were found to have chronic herpetic inflammation in the brain. The seizures took serial pattern with development of status epilepticus.

Adolescent↗
PubMed1992

[A variant of amyotrophic lateral sclerosis].

The results of the clinico-morphological studies carried out in 30 patients with the anterior-horn variety of amyotrophic lateral sclerosis (ALS) (CNS morphology was investigated in 6 cases) demonstrate this variety to be characterized by early fading of the tendinous periosteal reflexes, rapid development of amyotrophies, weak intensity of pyramid system lesions. This is supported by morphological studies of the CNS and allows advancing an opinion in favour of the priority of motoneuronal injury.

Adult↗
PubMed1992

[The clinico-pathogenetic characteristics of Kaposi's sarcoma].

The paper is concerned with clinicomorphological characteristics of endemic, immune and epidemic (AIDS-associated) forms of Kaposi's sarcoma (KS). Recent experimental and clinical evidence suggests pathogenic contribution to KS of virus-induced depression of sex-linked genes and immunosuppression. Combined action of these factors should be regarded when specifying current presentation of KS.

Acquired Immunodeficiency Syndrome↗
PubMed1991

[The morphological characteristics of the endocervicoses in genital herpes].

Uterine cervix biopsies from 450 patients with endocervicosis were studied morphologically. Giant cell metamorphosis, nuclei hypertrophy and hyperchromatism with intranuclear viral basophilic inclusions typical for herpes infection were found in 24 cases (5.3%). These cell alterations were mainly observed in squamous epithelium of the uterine cervix, columnar epithelium of the glands and to a lesser degree in the stromal fibroblasts and vascular endothelium. These morphological changes were confirmed in 6 of 10 cases by means of the fluorescent antibodies to the herpes simplex viral antigen.

Adult↗
PubMed1990

[Neurologic semeiotics of Jakob-Creutzfeldt syndrome].

The paper is concerned with the results of a clinicomorphological analysis of 17 cases of Creutzfeld's-Jacob disease (CJD) in patients aged 39 to 78 years. The authors show polymorphism of the clinical manifestations at the early stages of the disease and the necessity of differentiation between atherosclerotic dementia and tumors of the profound parts of the brain and sometimes with the high pattern of lateral amyotrophic sclerosis. The problem of the clinical varieties of CJD is discussed.

Adult↗
PubMed1987

[Subacute sclerosing panencephalitis in adults (clinico-morphologic study)].

Analysis of seven cases of subacute sclerosing panencephalitis in adults has revealed several clinical and morphological characteristics of this disease. The results indicate a tendency toward a chronic course of the process, the primary nature of ganglionic cell damage and the secondary nature of demyelinization, as well as a diagnostic value of the immunoperoxidase method in studying the central nervous system.

Adolescent↗
PubMed1985

[Pathologic anatomy of the central nervous system in subacute spongiform encephalopathy (Creutzfeldt-Jakob disease)].

The analysis of 7 cases of subacute spongiform encephalopathy, the Creutzfeldt-Jacob disease (CJD), is given. Three main morphological features are typical for this disease: spongiform change of the grey matter, progressive neuronal loss and proliferation of the astroglia cells. Unlike the other spongiform conditions, spongiform change in the CJD develops in neuropile of the brain grey matter. As a rule, the disease affects at first the cortex of the cerebral hemispheres, then subcortical nuclear groups, cerebellum and more rarely nuclear groups of the brain stem. The demyelinization of the white matter of the cerebral hemispheres is not obligatory for the CJD and appears in cases with a severe lesion of the grey matter.

Adult↗
PubMed1985

[Ultrastructural changes in the CNS in amyotrophic leukospongiosis].

Various types of cells in the human spinal cord and brain, status spongiosus of the white matter of the spinal cord were studied by electron microscopy; the comparison was made to the status spongiosus in monkeys with experimental amyotrophic leukospongiosis. The alterations in the motor neurons of the spinal cord, pyramidal neurons of the brain hemisphere cortex and cerebellum ganglious neurocytes were revealed. Changes in some cells (astrocytes, olygodendrocytes) were characterized. The possibility of a primary axon damage in this disease is discussed.

Animals↗
PubMed1985

[Clinical and experimental amyotrophic leukospongiosis (progressive spinal amyotrophy)].

The authors succeeded in reproducing amyotrophic leukospongiosis in experiments on two squirrel monkeys 16-23 months after challenge with cerebral suspension obtained at autopsy from a human patient. The clinico-morphological studies showed the similarity of the disease in humans and monkeys. A previously unknown agent belonging by its properties to "slow" viruses was isolated. The successful reproduction of amyotrophic leukospongiosis under experimental conditions proved its infectious nature.

Animals↗
PubMed1985

[Morphological changes in the brain of fetuses and newborn infants with diabetic fetopathy].

Brains of 13 newborns and 7 foetuses dying intranatally from mothers suffering from diabetes mellitus were examined. Morphological changes found permit making the conclusion about an unfavourable influence of diabetes mellitus on the developing foetus. Developmental disturbances in the central nervous system, such as slow down of the migration and differentiation of cells and degenerative changes in nervous and glial cells were observed. The cortex and brain stem were equally damaged. Certain morphological alterations in the hippocamp and vessels allow one to presume a relatively specific action of the mother diabetes mellitus on the foetal brain as similar changes are observed in adults with diabetes mellitus.

Brain↗
PubMed1983

[Pathology of hydranencephaly].

Data on pathological manifestations of hydranencephaly (3 cases) consisting of complete or nearly complete absence of cerebral hemispheres with the intact stem, cerebellum, spinal cord, meninges and skull bones are presented. A number of structural disorders were found in the remaining structures of the brain. A hypothesis on the origin of this central nervous system developmental defect is proposed: hydranencephaly is associated with disorders in the development of leptomeninges at the early stages of embryogenesis.

Adult↗