Hemoglobin switching in nonanemic sheep. 3. Evidence for presumptive identity between the A--C factor and erythropoietin.
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Amino Acid Sequence↗
Biomedical subjects
M K Shepard
Publications and source records attributed to M K Shepard.
Hemoglobins A and A2 in New World primates: comparative variation and its evolutionary implications.
Hemoglobin A(2) (alpha(2)delta(2)) in New World primates represents about 1/160 to 1/16 of total hemoglobin and, by virtue of this low proportion, is presumed to be functionally unimportant. Nonetheless, A(2) exhibits genetic polymorphism by electrophoresis in three out of five genera, whereas the major component, hemoglobin A (alpha(2)beta(2)), is electrophoretically invariant. Moreover, in four genera, including man, the evolutionary accumulation of mutations has been greater in delta than in beta Such findings suggest that both polymorphism and evolutionary changes can accrue to an effectively functionless and thus selectively nearly netutral gene.
Amino Acid Sequence↗
[Distribution of carbonmonoxide within the erythrocyte population in partial saturation].
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Carbon Monoxide↗