Comment: possible toxicity from propylene glycol in lorazepam infusion.
Explore the source record for details and available documents.
Adolescent↗
Biomedical subjects
M K Wilkin
Publications and source records attributed to M K Wilkin.
Ontogeny of renal hemodynamic response to renal nerve stimulation in sheep.
The renal hemodynamic response to direct electrical stimulation of renal nerves was studied in conscious and chronically instrumented fetal (130-142 days gestation; term 145 days), newborn (7-12 days postnatal), and adult nonpregnant sheep. Renal nerve stimulation (RNS) produced a significant decrease in renal blood flow (RBF) velocity and a significant increase in renal vascular resistance (RVR) in all three groups of animals. The overall decline in RBF velocity and the overall rise in RVR was less pronounced in fetal than in adult sheep (P less than 0.05). Changes in RBF velocity and RVR using an RNS frequency of 16 Hz were -35 +/- 4 and 81 +/- 19% in fetal sheep, -61 +/- 10 and 374 +/- 128% in newborn lambs, and -84 +/- 12 and 540 +/- 94% in adult sheep, respectively. RNS during intrarenal infusion of the alpha-adrenoceptor antagonist phentolamine was associated with a significant increase in RBF velocity and decrease in RVR in both fetal sheep and newborn lambs, but not in adult sheep. Moreover, it was found that the rise in RBF velocity and the decrease in RVR associated with RNS during alpha-adrenoceptor antagonism were completely inhibited by intrarenal infusion of ICI 118,551, a beta 2-adrenoceptor antagonist and unaffected by either cholinergic or dopaminergic antagonists. Taken together, these results suggest that the overall renal vasoconstrictor response to RNS is age dependent. Furthermore, the present results demonstrate that, contrary to observations made in adult animals, RNS can produce renal vasodilation in immature animals that is mediated by beta 2-adrenoceptors.
Adrenergic alpha-Antagonists↗
Linguistic background and test material considerations in assessing sentence identification ability in English- and Spanish-English-speaking adolescents.
This study investigated the influence of linguistic background differences on sentence identification by groups of English- and Spanish-English-speaking adolescents. Subjects were required to identify recorded meaningful and nonmeaningful (synthetic) sentences presented in a white noise background using a closed message set-response format. The results indicate that linguistic background variables significantly influence sentence identification ability and that these variables are not adequately controlled for by a closed message set. A significant difference in the ability to identify meaningful and nonmeaningful sentences was revealed. Contrary to previous indications, synthetic sentence identification appeared to be contingent upon key work or phrase recognition.
Adolescent↗