PubMed Health⌕ Search

Biomedical subjects

M Köhler

Publications and source records attributed to M Köhler.

291 records · Page 17Linked to original sources
PubMedDate not supplied

[Physical and exercise therapy in aged patients with peripheral arterial circulatory disorders].

Today the mean part of conservative treatment is the physical exercise therapy. This physical-therapy should be carried out through exercise in intervals. This training is programmed according to localisation and compensation of the occlusion and the age of the patients. The aims of the exercise-therapy are the adaptation of the motoric stressform coordination and improvement of local aerobic endurance. According to the location of the occlusion the muscles are trained: arm/exercise with dumb-bell; pelvis and thigh/exercise with knee-bendings; foot and calf/exercise with toestandings. This exercise therapy can also be successfully carried out by older patients suffering from vascular disorders.

Aged↗
PubMedDate not supplied

Early intensive and myeloablative adjuvant chemotherapy in women with high-risk breast cancer.

BACKGROUND: Women with breast cancer and > 10 positive lymph nodes have an unfavorable prognosis. The optimal combination and intensity of adjuvant chemotherapy is uncertain. Between July 1994 and December 1996 we treated 19 patients with early intensive followed by high-dose chemotherapy and autologous peripheral blood stem cell transplantation. PATIENTS AND METHODS: Patients were initially diagnosed with breast cancer and multiple positive lymph nodes. Induction chemotherapy consisted of two courses VP16, ifosphamide, cisplatin and epirubicin (VIPE) and one course of mitoxantrone, cyclophosphamide and thiotepa (MCT). Peripheral blood stem cells were mobilized after the first or second course of VIPE and retransfused two days after high dose chemotherapy. RESULTS: Stem cells were successfully collected in all patients. Major toxicities (WHO grade III and IV) were neutropenia, thrombocytopenia, alopecia, nausea, infections and mucositis. Hematopoietic recovery occurred in all patients with a median of 10 days for leukocytes and 13 days for platelets. No patient died of therapy-induced complications. The median observation time is 24 months. Two patients have relapsed, one with locoregional disease. The projected rate of patients with disease-free survival after three years is 88%. CONCLUSIONS: Early intensive and myeloablative chemotherapy followed by peripheral blood stem cell transplantation is a highly efficient and feasible protocol for high risk patients with breast cancer.

Adolescent↗