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Biomedical subjects

M Kühnert

Publications and source records attributed to M Kühnert.

At least 37 records · Page 2Linked to original sources
PubMed1990

[The enteral absorption of iron (II) from humic acid-iron complexes in suckling piglets using radiolabeled iron (59Fe)].

Bioavailability of iron (II) bounded as a chelate to macromolecular humic acids was investigated in two different concentrations using retention rates of 59Fe in piglets (age: 24 h). Investigations period was from 3 hrs. to 21 days following application. 21 days after a single oral application of the humic-acid-iron-complexes, 25% of the total Fe was detected in the animal, distributed in the erythrocytes (80%), muscles and bones (8% respectively) and liver (4%). For the first time in veterinary medicine these results enable a combined therapy of enteric and iron-deficiency syndrome by using only one drug. Recommendation for dosing is provided.

Animals↗
PubMed1989

[Pharmacologic and toxicologic properties of humic acids and their activity profile for veterinary medicine therapy].

Humic acids derive from a class of natural substances in humic substances. The chemical properties of certain defined humic acid products enable their application in diseases of the digestive system of mammals when combined with metabolic disorders, especially in rearing age. The simple administration (via feed), their exceptional safety and the absence of side effects (e. g. allergy, resistance) as well as no residue formation in animal derived products allow a broad application of these substances in veterinary medicine, even when regarding ecotoxicological aspects.

Animals↗
PubMed1987

[Results of treatment following stage-dependent therapy of non-seminomatous testicular tumors].

The results of the treatment of 194 patients with non-seminomas were analyzed and statistically registered. The therapeutic approach is described and the cumulative probability of survival is compared according to the stages. For the total number of these tumours a cumulative 5-year-survival probability of 68.6% was calculated. In detail it reaches from 100% in clinical stage I to 39.7% in clinical stage III. The decisive change of the prognosis is between the clinical stages IIb and IIc. An adjuvant cytostatic therapy should, if performed, be aggressive. Relapses in the clinical stage I are possible and call for a critical valuation of the primary stage. A retarded cytostatic polychemotherapy should be performed only under certain conditions.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[Long-term results of small intestine interpositionplasty].

The results of interposition plastic operations of the small intestine are presented which were performed in 8 patients. The control period comprises 4 to 23 years. The relatively complicationless postoperative course confirms an efficient technique, by means of which the functionless ureter may be bridged over. The function of the kidneys remains compensated and this the technique fulfils the main criterion of an operative technique conserving the organ.

Adult↗
PubMed1981

Evidence for participation of kinins in the antihypertensive effect of converting enzyme inhibition.

In low- and normal- renin hypertensive patients, but not in high-renin patients, the acute antihypertensive response to the angiotensin-converting enzyme (ACE) inhibitor captopril was completely blocked by aprotinin-induced kallikrein inhibition. Blood pressure reduction with long-term ACE inhibition could be overcome only in part by aprotinin. It is proposed that in low- and normal-renin hypertension the vasodepressor effect of acute ACE inhibition is mainly due to kinin accumulation. Conversely, in high-renin patients a fall in angiotensin II concentration accounts for the hypotensive response to captopril. From the pressor effect of aprotinin in chronically captopril treated patients it appears that kinins are also involved in the blood pressure reduction with long-term ACE inhibition. The finding that ACE inhibition and kallikrein blockade produced predictable and opposite effects on blood pressure suggests broad participation of changes in depressor kinin production in the control of vascular tone in essential hypertension.

Adult↗
PubMed1981

[Important nuclear medicine research methods in vesico-uretero-renal reflux].

The at present usual nuclear-medical methods in diagnostics and control of the course of the vesico-uretero-renal reflux are discussed. The semiquantitatively evaluated ING or the side-separated isotope clearance and the function scintigraphy are important parameters for therapeutic decisions in the basic diagnosis and the control of the course of the vesico-uretero-renal reflux.

Humans↗
PubMed1980

Altered blood pressure and renin responses to converting enzyme inhibition after aprotinin-induced kallikrein-kinin-system blockade.

1. The effect of aprotinin-induced blockade of the kallikrein-kinin system on haemodynamic and biochemical responses to converting enzyme inhibition by SQ 14 225 was evaluated in 26 patients with essential hypertension. 2. SQ 14 225 lowered blood pressure in high, normal and low renin hypertension. In low and normal renin patients, but not in high renin patients, the acute blood pressure-lowering effect of SQ 14225 could be overcome by aprotinin. Aprotinin infusion produced small vasopressor effects in all groups of patients. 3. Aprotinin lowered the level of circulating active renin but not that of inactive renin. 4. It is concluded that in low and normal, but not in high, renin hypertensive patients activation of the kallikrein-kinin system is responsible for the acute blood pressure reduction observed with converting enzyme inhibitions. 3. Aprotinin lowered the level of circulating active renin but not that of inactive renin. 4. It is concluded that in low and normal, but not in high, renin hypertensive patients activation of the kallikrein-kinin system is responsible for the acute blood pressure reduction observed with converting enzyme inhibition. 5. With long-term converting enzyme inhibition kallikrein-kinin system activation seems to play only a minor role. 6. The kallikrein-kinin system may be involved in the regulation of blood pressure. 7. There is no direct evidence of a participation of kallikrein in the activation of prorenin in vivo.

Aldosterone↗
PubMed1980

[Environmental pollution and toxicological assessment of major heavy metal (mercury, lead, cadmium) residues].

Correlations are elucidated between contamination of feedstuffs and animal-based foodstuffs as well as crops, with reference being made to pollution of the environment by and residualisation of mercury, lead, and cadmium compounds. Yet, necessary provisions regarding toxicological indices of residues of relevant metals in feed and food should make allowance also for unavoidable pollution of the environment by the toxic agent concerned. Orientation to what is called "normal" or background values in the ecosystem is absolutely essential to any assessment of metallic residues. The proposed WHO tolerances, in the context of animal-based foodstuffs, are 0.1 ppm maximum for mercury and cadmium and 0.5 ppm for lead. However, possible presence of all three toxic agents in one given food item has been left unconsidered in that tolerance proposal.

Animal Feed↗
PubMed1976

[Studies on the prenatally toxic effect of parathionemethyl in Wistar rats compared to cyclophosphamide and trypan blue].

Higher yield and performance in plant and animal production will depend on reinforced use of pesticides, particularly alkyl phosphate esters and insecticidal carbamates. Prenatal toxic action of the pesticides used today may be detrimental to human and animal health. Prenatal-toxicological tests, using parathion-methyl, were conducted on the basis of known but modified experimental methods. The vulnerability of a rat strain was tested by applying to it teratogenic model substances (trypan blue and cyclophosphamide). Several oral applications of parathion-methyl (3 ppm) during the sensitive phases of germ formation and growth (fifth to ninth and eleventh to fifteenth or eleventh to nineteenth days from conception) were followed by clear embryotoxic effects, such as retardation and increased resorption. The average number of resorption sites grew from nine in the control group to 20 in the experimental group. Postnatal malformations were not observed.

Abnormalities, Drug-Induced↗
PubMed1975

[Prenatal toxicology studies using sevin (carbaryl) in Wistar rats].

Oral administration of three doses of Carbaryl at 200 or 350 mg/kg body weight to pregnant female rats at various stages of fetal development had only slight teratogenic activity. Three doses of Carbaryl at 350 mg/kg given during the late embryonic or early fetal stages of pregnancy delayed fetal development; in the pre-embryonic stage it produced increased mortality of fertilized ova and increased the degree of retardation of individual fetuses. Similar results were produced by six doses at 200 mg/kg given on alternate days between the 5th and 15th days of embryonic development. It was concluded that the effects of Carbaryl on intrauterine development in rats were related to dosage.

Abnormalities, Drug-Induced↗