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Biomedical subjects

M Künzig

Publications and source records attributed to M Künzig.

10 recordsLinked to original sources
PubMed1979

[Treatment of psoriasis using vitamin A, vitamin A acid and oral retinoids].

Vitamin A, Vitamin A acid (retinoic acid) and their synthetic derivatives were variously applied in the management of psoriasis with different therapeutic results. Obviously, they influence the proliferation rate and the differentiation of human keratinizing epithelia and have beneficial effects on skin diseases with disturbances of keratinization, including psoriasis. Systemic application of Vitamin A has been yet largely abandonned since high dosages leading to clearing develop evident systemic toxicity. The anti-psoriatic effect of Vitamin A acid is either moderate or restricted, because of side effects. Only its combined local application with topical corticosteroids may be considered. Oral application of newly synthesized retinoids, however, was beneficial in psoriasis, particularly in erythrodermic or pustular types. With this group of retinoids new pathways were opened in dermatotherapy which may help to replace cytostatic drugs in these cases. Additionally, oral retinoid treatment may be introduced as an adjuvans in the management of widespread psoriasis, in order to enhance the effect of anthralin, PUVA or UVB treatments.

Female↗
PubMed1978

[Retinoid PUVA (RePUVA): systemic combination therapy in psoriasis].

RePUVA is a new therapeutic approach in psoriasis, consisting in oral administration of a retinoid derivative and systemic PUVA treatment. The retinoid (Ro 10-9359) was given daily (50--75 mg) before, simultaneously and, before and simultaneously with PUVA. The overall response was 73%; however, 14 patients resistant to previous standard PUVA treatment also responded surprisingly well to RePUVA. If PUVA-resistent patients were excluded, the overall response was 82.6%. The mean number of treatments required for clearing was 19.4 +/- 6.1, the mean total UVA-dose 57.9 +/- 32.3 J/cm2 and the mean duration of treatment was 55.4 +/- 14.1 days, including pretreatment with retinoid. It seems that RePUVA may be most successful if the retinoid is given before and with PUVA: 33.7 +/- 8.7 J/cm2 in 17.0 +/- 4.7 sessions were then required for clearing. Compared with previous results of our group and recent publications these findings indicate that the RePUVA schedule may reduce the duration of treatment and the total UVA-dose and, therefore, the possible long-term hazards of PUVA management. In addition, RePUVA can be successfully applied in patients resistant to standard PUVA.

Coumarins↗
PubMed1977

[Histopathological study of the mosquito-bite infiltrate in patients with various underlying diseases and different medications].

A histologic study was carried out on tissue-reactions after insect bits in 9 patients with various primary diseases. The clinical and cellular reactions to the bite in the epidermis varied, according to the length, intensity of toxity of the insect bit. The dermal infiltrate was similar in almost all cases and corresponded to a cellular immunologic reaction of the early or late type, as is also to be seen in trichophytin and tuberculin-reactions. Tere was clearly no relationship between the character of the dermal infiltrate and the basic disease. We also found no change in the dermal infiltrate due to special medicaments. Even corticosteroids did not suppress the dermal cellular reactions. There was also a striking absence of eosinophil leucocytes in the dermal infiltrate.

Culicidae↗
PubMed1977

[Square plastic using lower abdominal full skin].

The advantages of full thickness free skin grafting (Wolfe graft) from the hypogastricum are described in ten cases. The method is suitable for covering fresh skin defects--dermis and subcutaneous tissue--which results in dermato-tumorsurgery in extremities and skull region. The hypogastricum was taken as donor area because the wound edges can be closed in order to produce the least conspicuous scar. Large free skin grafts can be taken. The dermis is thin and promotes a good wound healing. For the take of the Wolfe graft the carfull removing of all visible fat on its under-surface is essential. The tendency of the graft to take is judged by morphological criteria and subdivided in five degrees. Most important for the final form of the skin graft is the local treatment.

Abdomen↗
PubMed1976

[A case of extreme gouty arthritis, shown xeroradiographically (author's transl)].

A case of extreme, obviously lead-induced gouty arthritis is described testing xerography for typical gouty changes. Xerography is less effective in showing differences of density than film-techniques. But highly structures shapes or their sudden abolition will be particularly clear owing to the effect of contour reinforcement. Defects of bone induced by tophi and new formations can be identified with certainly.

Aged↗
PubMed1975

[The cytochemical behavior of PAH-stimulated lymphocytes].

A comparison was made between the cytochemical behaviour of PAH stimulated lymphocytes and that of non-stimulated lymphocytes otherwise treated in the same way. Apart from non essential differences and the clear increase in size of the stimulated cells, there was no significant difference in the behaviour of stimulated and non-stimulated lymphocytes during the various reactions (non-specific esterases, acid phosphatase, alkaline phosphatases, naphtol ASD sodiumacetate-esterases, peroxydases leucine aminopeptidases, DOPA-reaction). There was no sign of lymphocytes being transformed into monocytes of fibroblasts.

Acid Phosphatase↗
PubMed1975

[Chronic lead poisoning: Lead gout with giant tophi on the skin, nephrophathy and porphyrinopathy].

Chronic lead nephtropathy, secondary gout (lead-gout) and porphyrinuria may develop after long lasting professional exposure to lead. A printer with giant tophi on his hands and feet excreted a significantly higher amount of lead after infusion of calcium EDTA in comparison with a normal control person. This result indicates an increased mobilization of lead from skeletal deposits. Furthermore, the laboratory findings showed renal insufficency and porphyrinuria up to 1316 mug/l (elevation of total porphyrins with slight or no elevation of delta-amino-levulic acid and porphobilinogene). The clinical triad nephropathy, secondary gout and porphyrinuria seems to be a variant of chronic lead poisoning.

Aged↗