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M KOGUT

Publications and source records attributed to M KOGUT.

9 recordsLinked to original sources
PubMed1964

THE SECOND INTERNATIONAL STANDARD FOR BACITRACIN.

The National Institute for Medical Research, London, was requested by the WHO Expert Committee on Biological Standardization to establish a second International Standard for Bacitracin since stocks of the first International Standard were running low. A batch of 500 g of zinc bacitracin was obtained in 1962 and was distributed into ampoules in 100-mg amounts and dried in vacuum; the ampoules were then filled with dry nitrogen and sealed. This proposed replacement material has been assayed biologically in terms of the first International Standard in seven laboratories in five countries by means of plate diffusion assays.In spite of a large difference in purity between the first and proposed second standards, the variation in the potencies obtained for the proposed second standard were small, although significant. This material has been established as the second International Standard for Bacitracin with a defined potency of 74 mg. The International Unit of Bacitracin is defined as the activity of 0.01351 mg of the second International Standard for Bacitracin.

Bacitracin↗
PubMed1963

THE INTERNATIONAL STANDARD FOR NYSTATIN.

At the request of a WHO Expert Committee on Biological Standardization, a batch of nystatin, comparable in purity to material used therapeutically, was submitted to an international collaborative study in nine laboratories in six countries. In this study the material was assayed by the plate diffusion method (and in one laboratory also by a turbidimetric method) against the United States Pharmacopeia Reference Preparation of Nystatin. On the basis of the results obtained the material has been established as the International Standard for Nystatin, and the International Unit of Nystatin is defined as the activity in 0.000333 mg of the International Standard.

Biological Assay↗