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Biomedical subjects

M Kagami

Publications and source records attributed to M Kagami.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Studies on the cell-mediated immunity caused by beryllium compounds].

In order to examine the sensitizing ability of beryllium (Be), a footpad reaction test and a macrophage migration inhibition test were carried out using mice treated with beryllium compounds. The findings of the experiments are summarized as follows: 1) The footpad reaction test of the mice injected with BeCl2 once a week subcutaneously at their dorsal area showed the positive results after four injections. The macrophage migration inhibition test was also performed by an agarose plate method using peritoneal cells and spleen cells obtained from these mice. The ratio of the number of positive mice showed more than 50% after five injections when peritoneal cells were used and after six injections when spleen cells were used. 2) The footpad reaction test of mice injected with one of various Be-compounds six times once a week showed a cross positive reaction against these compounds, and the macrophage migration of these mice was inhibited by these Be-compounds, but not by other metals. 3) When mice were once injected with 7BeCl2, about a half dose of the injected metal was discharged from the body within 7 days after the injection, and about a half dose of the residual metal was still found in the injected site. Further investigations may be required to solve the point that the persistent remaining of this metal in situ may raise the Be sensitizing ability.

Animals↗
PubMed1983

Regional variance of cerebrovascular mortality in Japan.

Cerebrovascular disease is a chronic disease reflecting the influence of many different factors. In postwar Japan, the disease has been the primary cause of death and its mortality has shown the obvious regional variance. The purpose of this study is to present and appreciate the regional variance of the disease in Japan. The first step was the observation of the general regional variance of the disease by the trend surface analysis. Next came the classification of the regional types of the disease, which may be the regional character, in order to appreciate the detail of the variance of the disease. Lastly, the factor of the regional variance was examined by temperature in winter. The general pattern of distribution reveals cerebrovascular mortality to be higher in the east of the country and lower in the west. In more general terms the highest mortality is located in northeast Japan, except Hokkaido, and the lowest in southwest Japan, especially in the Inland Sea region. The fact that the higher mortality is in the mountainous region and the lower is in the plains and basins suggests dependence on geographical variations between both regions. There is a strong relationship in Japan between cerebrovascular mortality and the lower temperatures of winter. The exception is Hokkaido, where the lower mortality may be the result of other regional factors such as unconventional lifestyle.

Cerebrovascular Disorders↗
PubMed1982

[Effects of aromatic nitro and amino compounds on the osmotic fragility of red cells].

Using the Coil Planet Centrifuge system, effects of single and repeated subcutaneous injections of p-nitrochlorobenzene [PNCB], aniline [AN] and phenylhydrazine [PH] on the osmotic fragility of red cell membrane in rabbits were studied. Methemoglobin [MHb] levels and appearance of Heinz bodies were also determined. In the single injection experiment, the osmotic fragility was increased immediately after the subcutaneous injections of PNCB [50 mg/kg, 100 mg/kg and 200 mg/kg], AN [50 mg/kg, 250 mg/kg and 500 mg/kg] and PH [25 mg/kg and 45 mg/kg]. The increased MHb levels were observed first, and secondly the maximum changes of the osmotic fragility and appearance of Heinz bodies were observed nearly simultaneouly after the injections of these three compounds. In the repeated injection experiment, hemolysis starting point was shifted toward higher osmotic pressure immediately after the injections of PNCB [5 mg/kg/day and 10 mg/kg/day], AN [20 mg/kg/day and 30 mg/kg/day] and PH [1 mg/kg/day and 3 mg/kg/day], while it was shifted toward lower osmotic pressure after the last doses of PNCB and PH. Hemolysis ending point was shifted toward higher osmotic pressure after the injections of PNCB [10 mg/kg/day] and AN, while it was shifted toward lower osmotic pressure after the injections of PNCB [5 mg/kg/day] and PH. The injection of PNCB induced continuously the increased MHb levels and appearance of Heinz bodies. The injection of PH induced the continuous appearance of Heinz bodies and the transiently increased MHb levels. Although the injection of AN induced the transiently increased MHb levels, there were no appearance of Heinz bodies. These findings show that the early and continuous changes in red cell membrane induced by these three compounds were able to be detected by the use of the Coil Planet Centrifuge system. The changes in red cell membrane induced by single and repeated injections of PH were able to be detected even when the increased MHb levels were not detected. Furthermore, the changes induced by the repeated injection of AN were able to be detected even when the increased MHb levels and the appearance of Heinz bodies were not detected. Thus, it seems likely that the Coil Planet Centrifuge method is useful to examine workers exposed to aromatic nitro and amino compounds.

Aniline Compounds↗