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Biomedical subjects

M Kajiyama

Publications and source records attributed to M Kajiyama.

At least 19 recordsLinked to original sources
PubMed1995

[A case report of primary pulmonary artery sarcoma].

A 49-year-old man was admitted because of dyspnea and generalized edema. CT scan pulmonary scintigram and cardiac catheter examination revealed pulmonary arterial obstruction due to a tumor associated with right heart failure. The tumor was extirpated as much as possible by a pulmonary arteriotomy under cardiopulmonary bypass. Postoperatively, right ventricular pressure decreased to about 40 mmHg while PO2 increased to the normal level. Histological examination of the tumor revealed rhabdomyosarcoma arising from the pulmonary artery. Chemotherapy consisting of a single course of CDDP and adriamycin was administered.

Humans↗
PubMed1995

[A case report of traumatic diaphragmatic hernia treated by thoracoscopic surgery].

A 56-year-old man who had been accidentally hit on the right side of the chest about 20 days previously was admitted because of intractable cough. Chest X-ray and CT scan revealed a right-sided diaphragmatic hernia and slight pneumothorax. No other hemorrhagic or perforative complications were detected. On the third hospital day, the patient underwent therapeutic thoracoscopy. Herniated transverse colon and liver were repaired through the abdominal cavity and the lacerated diaphragm was sutured through four thoracoports with video system assistance. The postoperative course was uneventful, and the patient was discharged 28 days later.

Endoscopy↗
PubMed1994

A simple surgical atrial septectomy for complex congenital heart disease.

A simple method of surgical atrial septectomy using a rongeur (Kerrison bone-cutting forceps), which is used in neurosurgery, is described. The closed rongeur is inserted into the left atrium through the right atrial appendage and the atrial septum. Then it is opened and the edge of the atrial septal defect and/or patent foramen ovale can be hooked by pulling slowly. The rongeur is then tightly closed again and pulled out together with the resected atrial specimen. This technique is safer and simpler than the Blalock-Hanlon technique or atrial septectomy with extra-corporeal circulation for older infants in whom balloon atrial septostomy is difficult.

Heart Defects, Congenital↗
PubMed1993

Evaluation of tumor markers in patients with squamous cell carcinoma in the oral cavity.

Serum levels of six tumor markers (carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCA), immunosuppressive acidic protein (IAP), alpha-fetoprotein (AFP), ferritin (FER), and carbohydrate antigen 19-9 (CA 19-9)) were simultaneously measured in 29 patients with primary squamous cell carcinoma (SCC) of the oral cavity to determine their significance. The positive rates were 34.5% for CEA, 41.4% for SCCA, 51.7% for IAP, 0% for AFP, 10.3% for FER, and 6.9% for CA 19-9 in patients with oral SCC. Therefore, CEA, SCCA, and IAP levels, of which the positive rates were significantly different (P < 0.01) from those of control patients without oral cancer, were considered to be of diagnostic value. The sensitivity (69.0%) and accuracy (90.3%) of the combination assay with these three tumor markers proved to be higher than those obtained with individual markers. A combination assay with CEA, SCCA, and IAP could be useful for the screening of patients with oral cancer.

Adult↗
PubMed1993

Treatment of isolated growth hormone deficiency type IA due to GH-I gene deletion with recombinant human insulin-like growth factor I.

Biosynthetic insulin-like growth factor I (IGF-I) was administered subcutaneously twice a day for one year to a patient with isolated growth hormone deficiency (IGHD) type IA with high titres of anti-GH antibody (up to 1:1,000,000). During IGF-I therapy he showed good linear growth without any side effects, such as hypoglycemia and anti-IGF-I antibody formation. Administration of IGF-I to IGHD type IA with poor response to GH therapy appears to have a beneficial effect on growth.

Antibodies↗
PubMed1992

Effect of long-term calcitonin therapy by injection and nasal spray on the incidence of fractures in osteogenesis imperfecta.

The effect of calcitonin therapy by injection or nasal spray on the incidence of bone fractures was studied in patients with osteogenesis imperfecta. In contrast to injection of calcitonin, intranasal administration of calcitonin twice a week for 2 weeks, followed by 2 weeks of no therapy, was simple and seemed beneficial for decreasing bone fractures in patients with osteogenesis imperfecta.

Administration, Intranasal↗
PubMed1989

[A case of mitochondrial encephalomyopathy with cardiomyopathy due to decreased complex I and IV activities].

We reported a girl with mitochondrial encephalomyopathy, who had various neuromuscular symptoms including dilated cardiomyopathy, generalized convulsions, myoclonus, muscular weakness and growth retardation. Lactate levels in the serum and CSF were elevated. Muscle biopsy showed scattered ragged-red fibers, and complex I (NADH-CoQ reductase) and complex IV (cytochrome c oxidase) were markedly reduced. Although she was treated with coenzyme Q, DL-carnitine and sodium succinate, she died of progressive congestive heart failure at 9 10/12 years of age.

Cardiomyopathy, Dilated↗
PubMed1989

[Direct percutaneous transluminal coronary angioplasty (PTCA) for treatment of acute myocardial infarction: comparison with PTCA immediately after thrombolysis].

We studied 73 patients with acute myocardial infarction (AMI) treated by percutaneous transluminal coronary angioplasty (PTCA) without thrombolysis (direct PTCA) and 52 patients with AMI treated by PTCA immediately after thrombolysis (PTCR + PTCA). The initial results, angiographic findings and preservation of ventricular functions of the direct PTCA group were compared with those of the PTCR + PTCA group. 1. The success rate of coronary recanalization was higher in the direct PTCA group than in the PTCR + PTCA group, but there was no statistical significance (89% vs 77%; p = NS). 2. Major complications occurred in 4.1% of the direct PTCA group and in 5.8% of the PTCR + PTCA group (p = NS). 3. The incidence of acute coronary reocclusion was higher in the PTCR + PTCA group than in the direct PTCA group (7.4% vs 22%; p less than 0.05). 4. Angiographic haziness at the dilated site following PTCA was seen more frequently in patients in the PTCR + PTCA group than in those of the direct PTCA group (43% vs 23%; p less than 0.05). 5. Patients with haziness at the dilated site had a significantly higher incidence of acute coronary reocclusion than did the patients without such haziness (28% vs 6.3%; p less than 0.05). 6. Left ventricular ejection fraction and regional wall motion were better preserved in the direct PTCA group than in the PTCR + PTCA group, but there was not statistical significance. It was suggested that direct PTCA is safe and can be performed with good success rates. It is superior to PTCR + PTCA in avoiding acute coronary reocclusion, and thus we supposed that the response of lesions to angioplasty may be altered by the administration of thrombolytic agents.

Adult↗
PubMed1989

[Effects of early myocardial reperfusion on left ventricular function in patients with acute myocardial infarction].

The effect of early myocardial reperfusion (within six hours after the onset of symptoms) on left ventricular (LV) function in 106 patients with acute myocardial infarction was studied. The subjects consisting of 26 with conventional therapy, 19 with percutaneous transluminal coronary recanalization (PTCR), 16 with percutaneous transluminal coronary angioplasty (PTCA) after PTCR, 32 with direct-PTCA and 13 with coronary artery bypass graft (CABG) were randomly observed after 1981. In these patients, left ventricular ejection fraction (LVEF), regional wall motion, end-diastolic pressure and the contractility index were measured as the indices of LV function. 1. Compared to the conventional therapy group, LVEF and regional wall motion improved significantly in all groups with reperfusion therapy except in the PTCR group. This LV function in patients with subtotal obstruction or good initial collaterals significantly improved compared to patients with total obstruction and no collateral circulation. Patients with a 75 percent or more residual stenosis after reperfusion therapy had significantly decreased LV function compared to those with residual stenosis of less than 75 percent. These findings support the potential role for reperfusion therapy in patients with acute myocardial infarction.

Aged↗
PubMed1988

The Perrault syndrome: clinical report and review.

We report on two Japanese sisters with Perrault syndrome, i.e., autosomal recessive ovarian dysgenesis associated with sensorineural deafness. They also had ataxic gait, pes equinovarus, nystagmus, limited extraocular movements, and short stature. One older affected sister had partial growth hormone deficiency. Our review included 21 patients from 8 families, including our patients; 16 are women with ovarian dysgenesis and deafness, 3 deaf males without gonadal defect, one a woman with ovarian dysgenesis without deafness, and one a girl with deafness in whom ovarian function was not evaluated. Perrault syndrome may not be uncommon; some cases may have gone unrecognized, especially when a single child in a family is affected.

Adolescent↗
PubMed1982

Superoxide dismutase in various tissues from rabbits bearing the Vx-2 carcinoma in the maxillary sinus.

Distribution profiles of superoxide dismutase isoenzymes in various tissues of rabbits with the Vx-2 carcinoma in the maxillary sinus were compared with those of control rabbits. Copper- and zinc-containing superoxide dismutase (Cu,Zn-SOD) activity in the liver of rabbits decreased significantly 3 weeks after transplantation. Manganese-containing superoxide dismutase (Mn-SOD) activity did not decrease significantly within 5 weeks after transplantation. In other tissues from the tumor-bearing rabbits, Cu,Zn-SOD and Mn-SOD activities were not changed within 5 weeks. No Mn-SOD activity and low Cu,Zn-SOD activity were detected in the Vx-2 carcinoma. These results suggest that the Vx-2 carcinoma has lost most of its ability to defend against oxygen toxicity and this ability decreased only in the liver of rabbits bearing the Vx-2 carcinoma in the maxillary sinus.

Animals↗