Biomedical subjects
Publications and source records attributed to M Kaleva.
Three cases of Dubin-Johnson syndrome in close relatives--brother, sister and a brother's son--are reported. The clinical characteristics, evolution, diagnostic and differential diagnostic problems as well as the treatment and prognosis of the disease are pointed out.
The frequency of cholelithiasis in Bulgaria has increased 9 times for the last 15 years. At the same time 40.5% of the patients with cholelithiasis are obese--II-IV degree of obesity. This fact calls for individualization of diet No 5 which in this country is applied to patients with liver and biliary diseases. A variant diet No 5-x for patients with cholelithiasis and abnormal body mass is proposed. This diet keeps the protein and fat components of diet No 5 but reduces the carbohydrates quantity from 346 g to 195-200 g which leads to the reduction of the daily intake of calories from 2369-2450 to 1700. The individualization of diet No 5 and the introduction of diet No 5-x in patients with biliary diseases will ensure a greater prophylactic and therapeutic efficacy of the dietetic treatment of patients with cholelithiasis and other biliary diseases combined with various degree of obesity.
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Cryptorchidism and hypospadias share possible risk factors, such as intrauterine growth retardation. According to the data collected by the International Clearinghouse for Birth Defects Monitoring Systems (ICBDMS), apparently increasing trends in the incidence of hypospadias were found in Sweden during the 1960s, and in Norway, Denmark, England and Hungary during the 1970s. In Norway and Denmark, the increase continued in the 1980s, while in the USA it has continued from the 1970s to the 1990s. Finland has shown a lower reported rate of hypospadias than other Nordic countries. However, it is difficult to make comparisons between countries because of variable inclusion criteria. Furthermore, the reliability of the data depends on correct ascertainment and reporting of the cases. The ICBDMS has also collected data on cryptorchidism, but these appear to be unreliable because of a discrepancy with the data from cohort studies. According to two comparable English studies, the incidence of cryptorchidism in full-term boys approximately doubled between the 1950s and the 1980s. Regionally there are large differences: e.g. in Finland the incidence of cryptorchidism is clearly lower than in Denmark. Regional and temporal trends may help to identify environmental factors that might be associated with these disorders.
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