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Biomedical subjects

M Kallos

Publications and source records attributed to M Kallos.

4 recordsLinked to original sources
PubMed1985

Five-year follow-up study of tardive dyskinesia.

A 5-year follow-up investigation of TD was carried out in 85 Hungarian schizophrenic out-patients. No substantial changes occurred during the 5 years in pharmacotherapy: most patients continued on neuroleptics and antiparkinson drugs. Comparison of 1978 and 1983 ratings revealed increased dyskinesia scores, which was statistically significant on the DRS Choreo-athetosis cluster. There was an increase in the number of patients with "moderately" severe TD from 4 in 1978 to 6 in 1981 to 10 (9 "Moderate" and 1 "Severe" TD) in 1983. The total number of TD cases as defined by research diagnostic criteria increased by only 3. The long-term trend in these neuroleptic-treated schizophrenics is for dyskinesia to plateau after reaching mild intensity, while in a minority of cases, the dyskinesia tends to extend from the oro-facial region to other body regions.

Antipsychotic Agents↗
PubMed1983

Changes in extrapyramidal symptoms following anticholinergic drug withdrawal.

An antiparkinson drug (APK) withdrawal study was carried out in 34 schizophrenic outpatients on maintenance neuroleptics. Sixty-five percent of patients were without major complaints after 2 weeks of APK discontinuation, while 35% reported adverse effects including extrapyramidal, autonomic, and behavioral symptoms. Male patients and those on higher diethazine doses before withdrawal reported more complaints. Ratings showed significant increases of parkinsonism, as well as dyskinesia following APK withdrawal. No clinical evidence was obtained in support of the notion of cholinergic hypersensitivity in patients showing "tremors" at baseline.

Antiparkinson Agents↗
PubMed1980

Absence of severe tardive dyskinesia in Hungarian schizophrenic out-patients.

One hundred and twenty-two patients comprising 82% of the non-hospitalized schizophrenic population of a Hungarian town were rated for tardive dyskinesia (TD). Drug histories were also obtained. No severe cases of TD were found. The markedly lower prevalence of TD in the study population in contrast to similar North American samples may be related to differences in treatment styles, in particular to: a) use of EST in place of high-dose neuroleptic therapy; b) extensive exposure to ethopropazine, promethazine, and other antiparkinson drugs. Twenty patients revealed clinically evident fine tremors, mostly of the tongue and eye-lid. Multivariate analysis revealed a positive association of choreiform dyskinesia with duration of low-potency neuroleptic treatment.

Adolescent↗