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Biomedical subjects

M Kamide

Publications and source records attributed to M Kamide.

28 records · Page 2Linked to original sources
PubMed1988

[Combination chemotherapy with cisplatin and UFT malignant tumors of the head and neck--experimental study of human nasopharyngeal carcinoma (A2L/AH) xenografted to nude mice].

Combination therapy with cis-platinum (CDDP) and UFT was examined with human nasopharyngeal carcinoma (A2L/AH) implanted in nude mice. The tumor growth of A2L/AH was inhibited in the group administrated UFT 20mg/kg, but was not in 10mg/kg group in comparison with the control group. An inhibition rate (IR) of the tumor growth was 80.2 and 21.3% respectively. The group received CDDP (5mg/kg, q7d X 3, 2mg/kg, q7d X 3 and 1 mg/kg, qd X 6) by i. p. injection, resulted in 75.2, 37.4 and 23.1% inhibitions respectively. While, the response rate in the group treated with CDDP (1 mg/kg, qd X 6) and UFT (10mg/kg) showed a synergistic effect (IR; 66.3%) which was higher than in the group administrated CDDP (2mg/kg, q7d X 3) and UFT (10mg/kg) (IR; 58.3%).

Administration, Oral↗
PubMed1984

Establishment of Epstein-Barr virus (EBV)-associated nuclear antigen (EBNA)-positive nasopharyngeal carcinoma hybrid cell line (NPC-KT).

Primary nasopharyngeal carcinoma (NPC) cells were fused to hypoxanthine-guanine phosphoribosyltransferase (HGPRT)-defective cells derived from adenoid tissues using Sendai virus. Some of the fused cells developed into epithelial-like hybrid cells in a selective HAT medium. The hybrid cells (NPC-KT) were Epstein-Barr virus (EBV)-associated nuclear antigen (EBNA)-positive cells. There have been no reports on the establishment of EBNA-positive epithelial cell lines derived from NPC. Thus, the epithelial-like hybrid cells might serve as an in vitro model for studying the biologic activity of NPC-associated EBV.

Aged↗
PubMed1981

Effects of adrenal demedullation and peripheral noradrenaline-depleting agents on adrenocortical function and spleen in rats.

Adrenocortical functions of adrenal-demedullated rats (ADMx rats) and peripherally chemical-sympathectomized ADMx rats were studied by examining changes in the levels of serum and adrenal corticosteroids (CS). Resting levels of serum and adrenal CS were not influenced by adrenal-demedullation and peripheral chemical-sympathectomy with 6-hydroxydopamine. Diurnal variation in serum CS concentration was also unchanged, suggesting that peripheral adrenergic systems do not influence the basal function of hypothalamo-pituitary-adrenocortical axis. Exposure of ADMx rats to the stressful stimuli, however, resulted in lowered adrenocortical response with a lesser increase in serum CS concentration, while peripheral chemical-sympathectomy of ADMx rats with 6-hydroxydopamine or guanethidine caused a significant enhancement of adrenocortical response to the stress with elevation of the serum CS concentrations. These findings suggest that increased peripheral adrenergic activity may suppress the activation of the hypothalamo-pituitary-adrenocortical system as the animals were exposed to the stressful stimuli. Adrenal-demedullation produced no increase in spleen weight while chemical-sympathectomy by peripheral administration of 6-hydroxydopamine did produce a significant increase in the weight of this organ. Histological features following chemical-sympathectomy are described.

Adrenal Cortex↗