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Biomedical subjects

M Kashimura

Publications and source records attributed to M Kashimura.

At least 91 records · Page 5Linked to original sources
PubMed1985

Gestational trophoblastic disease in women aged 50 or more.

Twenty cases of gestational trophoblastic disease in women aged 50 or more are reported. The lesions were 7 hydatidiform mole (35%), 8 invasive mole (40%), and 5 choriocarcinoma (25%). The most common presenting symptom was abnormal vaginal bleeding. Three choriocarcinoma patients were postmenopausal and all of them had choriocarcinoma. None of the patients with hydatidiform mole or invasive mole died of the disease, but 4 of 5 choriocarcinoma patients died of the disease. Because of the high rate (56.3%) of malignant sequelae after molar evacuation, a primary hysterectomy for the treatment of hydatidiform mole in this age group is recommended. It is important to maintain a high level of suspicion for the diagnosis of gestational trophoblastic disease in the elderly women.

Age Factors↗
PubMed1985

Labyrinthine structure of arterial terminals in the human spleen, with special reference to "closed circulation." A scanning electron microscope study.

Spleens of normal structure were obtained in surgery on nine patients with gastric cancer. The freeze-cracked surfaces of the organ as well as the vascular casts of methacrylate resin were examined by scanning electron microscopy. Penicillar arteries were confirmed to terminate in the cords of Billroth, representing the open circulation. Labyrinthine channels of arterial capillaries were found in restricted regions in the red pulp neighboring pulp arteries and veins. They characteristically possessed in their lumen spanning trabecullae covered with endothelial cells. In some places, the flat endothelium of a channel continued to the lattice-like endothelium of a thin sinus, representing closed circulation. The occurrence and distribution of the arteriolar labyrinths were confirmed by SEM observation of the vascular casts. Their continuation to the thin sinuses was also demonstrated in the casts. The present study evidences that in the human spleen, specialized arteriolar terminals provide a closed circulation route in restricted regions, besides the hitherto known, predominant route of open circulation.

Arteries↗
PubMed1984

Stage Ib, IIa, and IIb cervix cancer, postsurgical staging, and prognosis.

Two hundred fifty-five cases of International Federation of Gynecology and Obstetrics (FIGO) Stage Ib, IIa, and IIb cases of cervical cancer were analyzed following radical surgery with regard to the extent of invasion into vagina, parametria, and pelvic lymph nodes. Restaging was carried out based on the findings. Discrepancies were found between FIGO stages and the actual extent of the disease, particularly in Stage IIb. Among 99 cases of Stage IIb, only 42.4% were correctly staged. The 5-year disease-free survival by FIGO and postsurgical stagings were, respectively: Ib, 88.4% and 87.0%; IIa, 85.2% and 95.0%; IIb, 70.7% and 62.3%. Prognostic significance in the pathologic examination of operated materials was demonstrated when there were deep stromal invasions of cancer cell or parametrial invasions or pelvic lymph node metastases. When cancer was present in both of the parametrium and pelvic lymph nodes, the prognosis of the patient worsened (5-year survival rate, 41.4%).

Adenocarcinoma↗
PubMed1984

Cyclophosphamide-induced interstitial pneumonitis in a patient with ovarian carcinoma.

A 40-year-old female with ovarian cancer being treated with daily oral cyclophosphamide developed fatal interstitial pneumonitis. Autopsy did not show any evidence of ovarian cancer. The review of the literature revealed eight reported cases of cyclophosphamide-induced interstitial pneumonitis and fibrosis. The case is reported to alert gynecologists to this rare but lethal complication of cyclophosphamide.

Adult↗
PubMed1984

Verrucous carcinoma of the uterine cervix: report of a case with follow-up of 6 1/2 years.

A case of verrucous carcinoma of the uterine cervix was reported with a long-term follow-up and close observation. The patient was a 73-year-old, Japanese female, who had a suspicious Papanicolaou smear on routine examination. The cervix was replaced by a papillary mass, which was diagnosed as benign papilloma. The patient was followed every 6 months with cytology, colposcopy, and punch biopsy. No cytologic or microscopic diagnosis of invasive squamous cell carcinoma was made during the entire follow-up period. Total abdominal hysterectomy and partial vaginectomy were performed after 6 1/2 years' follow-up, and the tumor was finally diagnosed as verrucous carcinoma. The patient is alive and well 4 years after the operation.

Adult↗
PubMed1984

[Evaluation of cervical conization as a definitive treatment for borderline lesions of the uterine cervix].

Therapeutic efficacy of cervical conization was examined on 93 patients with borderline lesions of the uterine cervix who underwent hysterectomy following conization. No lesions or only minimal residual lesions were found at subsequent hysterectomy when the surgical margins of cone specimens were not involved in the malignant or premalignant lesions. From these results, we concluded that cervical conization could be considered as a therapeutic procedure when the following conditions were fulfilled. Cone specimens are sufficient in size. Both endocervical and exocervical margins are negative. No malignancy is found on endocervical curettage. No abnormal cytologic findings are found after conization. Another follow-up study was performed on 69 patients who received therapeutic conization between 1971 and 1981. Among them one developed stage II cervical cancer two years after the last follow up. Two other patients had recurrent CIN in the cervix and another patient was found to have an endometrial cancer. These patients were successfully treated after early detection of the lesions by the cytological examination. From these facts, cytological examination is recommended in the follow-up after therapeutic conization.

Adenocarcinoma↗
PubMed1982

[Therapeutic results of DCMP therapy (2M-80) in acute non-lymphocytic leukemia--the relationship between the residual leukemic cells and duration of remission].

In this study the duration of complete remission by daunomycin, cytosine arabinoside (Ara-C), 6MP and prednisolone (DCMP) therapy using a large dose of Ara-C (200 mg) (protocol 2M-80) was compared with that of DCMP therapy with a low dose of Ara-C (80-160 mg) in acute non-lymphocytic leukemia (ANLL). In protocol 2M-80, the chemotherapy was continued until leukemic blasts in marrow were attained below 3%. Complete remission was induced in about 80% of ANLL patients in both chemotherapies. However, the duration of remission in protocol 2M-80 appeared to be much longer than that of DCMP therapy with a low, dose of Ara-C. This difference was dependent not on the consolidation and maintenance therapy, but on the total dose of Ara-C used and leukemic blasts left in marrow at the end of chemotherapy. This suggests that it is important to reduce leukemic blasts in marrow as low as possible by induction chemotherapy to obtain a long-term remission in ANLL.

Acute Disease↗
PubMed1982

[Over diagnosis of the biopsy: from the analysis of the extirpated uterus after radical hysterectomy (author's transl)].

From January, 1973 to December, 1980, 396 cases of cervical cancer were treated with radical hysterectomy under the diagnoses of stage Ib, IIa and IIb. Precise postoperative pathological examinations about the extirpated uterus revealed that 63 of them had only early invasive cancer or less advanced lesions though they had been considered as frank invasive cancer by preoperatively performed biopsies. The major causes of the misinterpretations were, 1) misjudging the glandular involvements as frank invasive lesions, or 2) misjudging the tangentially sectioned lesions of the bulky outgrowth as frank invasions. Furthermore, it is sometimes difficult to identify the invasive lesions in the biopsy specimens whether they are early invasive or frank invasive. Colposcopic and cytological examinations were simultaneously performed to each cases. Either cytology or colposcopy did not suggest frank invasions in 44.2% of cases. Both of them did not suggest frank invasions in 37.2% of cases. At least, cone biopsy should have been performed to identify the degree of invasions of these 37.2% cases. The authors emphasize that the directed biopsies are not always accurate to diagnose the early invasions, and one should use colposcopy, cytology and directed biopsy to make an accurate diagnosis.

Adenocarcinoma↗
PubMed1982

Scanning electron microscopy (SEM) studies of the spleen--normal and pathological.

This paper reviews the SEM observations on normal and pathological human spleens. The findings reported by other research groups are briefly introduced. The white pulp is supported by a network of trabecules which may be partly hollow inside and represent a hitherto unknown channel system of highly variable calibers. The marginal zone or the perifollicular red pulp receives much arterial blood from the follicular arteries. The spongy spaces of the marginal zone also contain many lymphocytes. The arterioles in the red pulp open into free spaces in the cords of Billroth. Red cells which have lost plasticity as the result of aging or by taking the shape of stomatocytes and spherocytes in such hematological diseases as hereditary spherocytosis (HS), are interrupted by the narrow slits on the sinus wall, and phagocytosed by patrolling macrophages more easily than normally. SEM images support the view that the particulate matters in blood cells, like intracellular parasites, may be squeezed through the sinus slits ("pitting function") while the cells transit from the cord into the sinus. The sinus rod cells are normally connected with each other by their side processes leaving spindle-shaped slits in between. These rods are adhered together in different pathological conditions, i.e., in hepatosplenic diseases such as hepatic cirrhosis and portal hypertension and in such hematological diseases as HS and idiopathic thrombocytopenic purpura (ITP). Increased thread-like projections of the rods are noticed in these diseases. SEM observations indicate that macrophages are cells which are independent of both reticular and endothelial cells. In most pathological spleens, macrophages are observed to be elevated in phagocytotic activity. They take up erythrocytes vigorously in the spleens of HS and incorporate numerous blood platelets in the cases of ITP.

Erythrocytes↗
PubMed1982

Scanning electron microscopy studies of bone marrow.

This paper reviews scanning electron microscopy (SEM) observations of bone marrow, based on our findings on the marrow of rat femur and tibia. The marrow sinuses are lined by an endothelium, of which the cell juncture is undulated and overlapping. The endothelium is backed by a thin sheet of adventitial cells which is discontinuous because of large perforations. Mature blood cells pass through the discontinuous parts of the adventitial cells and then penetrate the endothelium at its parajunctional zone. Mature megakaryocytes reveal the demarcation membrane system in their cracked surfaces, and its orifices in their surface. The platelet liberation is visualized by a bunch of ribbons projected from a megakaryocyte into the sinus lumen; these ribbons become beaded and then separate into platelets. After puncture perfusion into the parenchyme of marrow, erythroblastic islands can be clearly demonstrated by SEM. Erythroblasts with rhopheocytotic pits are embraced by a nursing cell which, with its filopodia and lamellipodia, corresponds to the macrophage and clearly differs from the reticular cell. The nursing cell differs in size from island to island and occasionally shows indications of cell death. The erythroblasts in an island may be in a uniform maturation stage or in a few different stages. Adipose cells in the marrow are observed and their relation to reticular cells is discussed.

Animals↗
PubMed1981

The non-specific binding of thermally denatured DNA by healthy human sera in Farr assay with or without addition of dextran sulfate and calcium chloride.

A non-specific DNA binding by human sera was measured in 60 male and female healthy subjects in different ages. Farr assay using thermally denatured mouse embryo [3H]DNA proved a high DNA binding level of 47.9 +/- 5.8% (mean +/- S.D.) on an average of these sera. The addition of dextran sulfate and CaCl2 significantly decreased the mean binding value to 14.7 +/- 4.8% and 6.5 +/- 3.2%, respectively. No significant difference was observed between men and women, or between any age groups from twenties to sixties. The measurement of complement activity in the serum gave no evidence for the participation of complement in the non-specific DNA binding.

Adolescent↗
PubMed1981

Differentiation of specific DNA binding activity of SLE sera from non-specific binding by an addition of dextran sulfate and calcium chloride to the Farr assay system.

A new method for differentiation of specific DNA-binding by human sera from non-specific binding was evaluated with sera from patients with systemic lupus erythematosus in different stages of the disease. An addition of dextran sulfate or calcium chloride to Farr's radioimmunoassay mixture reduced non-specific binding of thermally denatured [3H]DNA of the patient sera without much effect on the specific binding. The measurement of DNA-binding value by the sera in these addition systems provides accurate information with regard to the pathophysiological state of the disease.

Adolescent↗
PubMed1981

Antigenic structure of DNA: relatively high inhibitory activity of di- and trideoxyribonucleotide derived from DNase digest on the interaction of thermally denatured DNA with systemic lupus erythematosus sera.

The antigenic determinant of thermally denatured DNA reactive with systemic lupus erythematosus (SLE) sera was examined by hapten inhibition assay. We used oligonucleotides with different chain lengths (2-8) derived from DNase I digests of salmon sperm DNA in Farr's radioimmunoassay with thermally denatured mouse embryo 3H-DNA as antigen, and the effect of dextran sulphate addition to the assay mixture on the inhibitory activity of oligonucleotides was examined. A characteristic oligonucleotide inhibition pattern on DNA binding by SLE sera was observed in the assay system without dextran sulphate. Di-and/or trinucleotide inhibited the binding more effectively than tetra-and/or pentanucleotide. These patterns were also observed in DNA-normal serum interaction. When dextran sulphate was added to the mixture, the inhibition pattern changed; the inhibitory activity of oligonucleotides increased with chain length in both serum groups. The inhibitory potency of di- and trinucleotide was higher on DNA-SLE sera than on DNA-normal sera interaction. The high potency of short-chain oligomers in SLE sera is obviously different from that in experimentally elicited anti-DNA sera suggesting that different mechanism(s) are involved in antibody production in normal individuals and SLE patients.

Adult↗