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M Kaska

Publications and source records attributed to M Kaska.

15 recordsLinked to original sources
PubMed2006

Post-operative intraperitoneal adhesion prevention--the recent knowledge.

This article deals with the current knowledge on the possibilities of intraperitoneal adhesion prophylaxis in correlation with intraperitoneal interventions in abdominal surgery. The up-to-date experimental possibilities and other known methods are presented. These include: Intraperitoneal perfusion by certain special simple solutions--Dextran, Carboxymethycellulose, Crystalloid solutions, and Hyaluronidase. Intraperitoneal or other administration of certain drugs--Tetracyclines, Cephalosporins, Corticosteroids, Non-Steroidal Anti-inflammatory drugs, Histamine agonists, Ca-channel blockers, Heparin, Citrates and Oxalates, Streptokinase, Urokinase, Plasminogen activators, and application of special synthetic or natural materials intraperitoneally--Surgicel, Interceed, Gore-Tex, Fibrin Glue, or various combinations of the above mentioned. Rats, rabbits, and mousses were used, first of all, as an animal model in presented experiments.

Abdomen↗
PubMed2004

[Jejunal diverticulosis as a rare cause of massive bleeding into digestive tract].

The authors present a case of an elderly man, who was admitted to the hospital due to unusual cause of massive bleeding into digestive tube. During diagnostic work-up the source of gastrointestinal bleeding was localized into jejunal divertuculum. The patient was operated on and resection of involved jejunal segment with primary anastomosis was performed. The possible complications ofjejunal diverticulosis are discussed.

Aged↗
PubMed2003

[Surgical stress and biochemical indicators].

AIMS: An investigation of some relationships of routinely and rarely used biochemical markers to surgical (operating) trauma. PATIENTS AND METHODS: A group of 37 patients was divided to two subgroups according type of disease with need a resection of large bowel for malignant or benign malady. Large bowel adenocarcinoma was dominated in a subgroup of malignancies (23 patients, mean BMI 25.59, mean age 63.65 years) and Crohn's disease and complicated diverticullary disease were the reasons to operate in the second subgroup of benignities (14 patients, mean BMI 21.21, mean age 39.5 year). Blood samples were taken before an operation, postoperatively (immediately) and at 6:00 a.m. the 1st, 3rd and 5th postoperative day. The routine methods (albumin, CRP, cholinesterase, haptoglobin, cholesterol), special methods (SOD, glutathion) and ELISA methods (leptin, IL-2r, IL-8, TNF)were used for evaluation markers. The results were estimated by statistic methods Sigma-Stat, One Way ANOVA and linear regression test. RESULTS: The mean serum concentrations of albumin, leptin, cholesterol shifted down very clearly compared to preoperative values. The mean serum concentrations shifted up the 3rd day postoperatively to 722% in benignities and to 1814% in malignancies respectively. The values of cholinesterase, glutation, SOD, and haptoglobin didn't show any more serious dynamics perioperatively. The serum leptin concentrations correlated with BMI but other markers serum concentrations didn't correlate with BMI or with age. CONCLUSIONS: The serum leptin, albumin, haptoglobin, CRP concentrations demonstrated serious dynamics perioperatively. These concentrations are stabilized and they reach preoperative levels the 5th postoperative day. Each-other markers correlation is minimal.

Adult↗
PubMed2002

[Serum leptin levels in the perioperative period in surgery patients].

AIM: To assess dynamics of serum leptin concentrations (as a possible marker of stress) at some surgical patients during short perioperative period. PATIENTS AND METHODS: The serum leptin concentrations were estimated in group of patients with trauma or large bowel diseases in stress of both own disease and next elective or urgent surgery. The subgroups of patients were: a) monotrauma (13), b) polytrauma (10), c) malignant (20) or d) inflammatory disease (13) of large bowel. The serum leptin concentrations were evaluated preoperatively and during 16 hours postoperatively-immediately after surgery, after 8 and 16 hours after operation. The serum IL-6 concentrations were estimated immediately and 48 hours postoperatively. RESULTS: The serum leptin concentrations showed a time depending dynamic phase: they decreased postoperatively and increased during the first 16 hours postoperatively. It was more expressed in the malignant bowel disease subgroup. A correlation between age and serum leptin concentrations was not found in any subgroup. We found correlation between serum leptin concentrations preoperatively and postoperatively. CONCLUSIONS: The serum leptin concentrations demonstrated some dynamics in short perioperative periods. It was very considerably in patients with large bowel malignancy. Any significant difference in serum IL-6 concentrations was not discovered preoperatively and postoperatively in all subgroups.

Humans↗
PubMed2001

Gastric banding: intraoperative and early postoperative complications and their prevention.

BACKGROUND: Intraoperative and early postoperative complications in patients operated for morbid obesity were assessed. METHODS: 114 morbidly obese patients underwnent gastric banding (non-adjustable or adjustable). The influence of body mass index (BMI), age and preoperative morbidity on the occurrence of postoperative ventilatory disturbances was evaluated. RESULTS: Risk of postoperative ventilatory disorders increased with preoperative cardiovascular disease (p < 0.01), diabetes (p < 0.05), and increasing BMI (p < 0.01). Age, hypertension and pulmonary disease did not influence significantly the risk of complication in this series. There have been no deaths. CONCLUSION: In patients undergoing banding for morbid obesity, the potential for ventilatory complications increases with higher BMI, diabetes and cardiovascular disease in the preoperative comorbidities. Principles for postoperative care were developed.

Adolescent↗
PubMed2001

[Recurrent adhesive ileus after surgical treatment of ovarian teratoma, malposition of an intrauterine device and dolichosigmoid--case report] ].

A 30-year-old woman was operated for ovarian teratoma and repeatedly for adhesive ileus during 1995-1999. A partial left ovarectomy, extirpation of an intrauterine device (IUD) in malposition (greater omentum) and appendectomy were performed during the first operation. Early adhesive ileus developed on the fourth postoperative day. Adhesectomy was performed in the region of the terminal jejunum. A new adhesive ileus developed after twenty seven months when patient underwent laparoscopy for gynaecological problems with conversion to laparotomy because of greater adhesions intraperitoneally another adhesectomy was performed. During the next eleven months new adhesive obstructions of the bowel developed and a third operation had to be performed incl. resection of the dolichosigmoideum on account of chronic problems during defaecation. A special tube as a intraluminal splint was inserted as prophylaxis of mechanical ileus in the postoperative period. But during next thirteen months subileous conditions and mechanical ileus developed again (up to now). The picture of intraperitoneal conditions was disastrous: almost total fibrotic changes allowed only partial adhesectomy. The passage through bowel is limited and is restricted to dietetic and medicamentous preparations. This case-report demonstrates postoperative adhesions a very old and very serious problem at the beginning of the third millennium.

Adult↗
PubMed2000

[Diverticulosis of the small intestine--case report].

The authors describe the case of a 86-year-old female patient admitted to hospital with acute abdomen of the inflammatory type. The condition developed in the course of cca three days with sudden deterioration on the day of admission to hospital. Contrast X-ray examination revealed perforation of the distended jejunum and surgery revealed diffuse peritonitis the source of which was the mentioned perforation associated with mechanical ileus caused by malrotation and adhesions of the small intestine. An additional finding which, however, dominated on X-ray examination of the gastrointestinal tract when using contrast material and on revision of the peritoneal cavity was multiple diverticulosis of the small intestine. The uncommon finding on the small intestine and the relatively sparse data in the literature on diverticulosis of the jejunum and ileum made us submit the case-history for publication.

Aged↗
PubMed1994

[Severe acute pancreatitis].

The authors present a group of 31 patients with severe acute pancreatitis (SAP) treated by early or late surgery and prophylactic, symptomatic and causal medicamentous therapy of a different extent. The diagnosis of SAP is based above all on examination by CT after administration of a contrast substance into the digestive tract and vascular system. Surgical intervention during the first 2-5 days reduces the mortality substantially. It involves above all removal of necrotic masses and administration of multiple drainage. Repeated rapid revisions of the affected area make open packing possible or the use of Ethizip. In non-surgical treatment administration of broad spectrum antibiotics, vitamins, scavengers of free oxygen radicals, antiphlogistic agents, corticoids, immunopromoting preparations, extensive symptomatic individual medication, large volumes of fluids and adequate parenteral nutrition predominate. Controlled ventilation and haemodialysis are in many patients an integral part of treatment. The mortality was about 42% when treatment was early and adequate. In patients where treatment started late and was inadequate, the mortality was as much as twice as high!

Acute Disease↗
PubMed1976

Exocellular proteases of Serratia marcescens and their toxicity to larvae of Galleria mellonella.

Out of 18 strains of Serratia marcescens producing exocellular proteases the strain Serratia marcescens CCEB 415 was selected according to preliminary experiments. It could be shown that the train exhibits proteolytic activity reaching up to 10 TU per 1 ml of the culture filtrate in a medium with gelatine and peptone. Two proteolytic enzyme could be demonstrated by means of specific inhibitors EDTA and diisopropyfluorophosphate: metalprotease with optimum activity at pH 7.5 and serine protease with pH optimum of 10.9. The enzymes were purified on Sephadex and DEAE cellulose columns and by means of gel electrophoresis. However, it was not possible to separate them. The optimum temperature for activity of the mixture of the two enzymes was 50degrees C, molecular weight varied around 37000 (according to gel filtration); certain kinetic characteristics of their activity were determined. Excess subtrate (casein) inhibited activity of the enzyme mixture. Toxicity of proteases expressed as LD50 units equals 78 - 10(3) TU per larva of Galleria mellonella.

Animals↗
PubMedDate not supplied

Pathomorphological changes in microcirculation of pancreas during experimental acute pancreatitis.

BACKGROUND/AIMS: Severe acute pancreatitis is prevalent in Eastern Bohemia (a part of the Czech Republic) and remains a very difficult problem to manage. Recent studies in treatment there are quite frequent but a direct view into the pancreas during its inflammatory process is very rare. Only information about a normal pancreatic microvascular bed appears to be available. This study was designed to explore pathomorphological changes in pancreatic microcirculation at the start and during the development of acute pancreatitis. METHODOLOGY: A group of 50 laboratory white rats was studied. The acute pancreatitis was induced by the modified method of Siech et al. The method of clamping of biliopancreatic duct and stimulation of external secretory tissue by a cholecystokinin and secretin and oral (orogastric tube) ethanol administration was performed. The pancreatic microvascular patterns were observed by using histochemical and corrosion casts methods. RESULTS: The study of the corrosion casts of pancreatic microcirculation in the scanning electron microscope and histochemical studies demonstrated the visible reduction of the pancreatic microvascular bed 18 hours after induction of acute pancreatitis. The microvascular bed is not fully destroyed until 48 hours of acute pancreatitis. CONCLUSIONS: The model of acute pancreatitis using postoperative application of ethanol to the digestive tract after stimulation of pancreas by cholecystokinine and secretin in the rats seems to be real and useful. The study of the corrosion casts of microcirculation in the scanning electron microscope and histochemical studies demonstrated the visible reduction of the pancreatic microvascular bed 18 hours after induction of acute pancreatitis. The microvascular bed is not fully destroyed until 48 hours of running acute pancreatitis, as some "islets" of the vital tissue still have undestroyed microvessels at this time. Despite the above-mentioned serious changes, restricted pancreatic microcirculation enables blood and medicament distribution to the still intact pancreatic tissue.

Acute Disease↗