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Biomedical subjects

M Kata

Publications and source records attributed to M Kata.

At least 19 recordsLinked to original sources
PubMed1990

Production and investigating of tablets containing furosemide and beta-cyclodextrin.

Furosemide is a very active drug with an excellent saluretic effect, but it dissolves in water only with difficulty. Furosemide products with beta-cyclodextrin (CD) have been made by five methods, and it has been established that most drugs are liberated most quickly from the kneaded product for the 12.72% combinations. The dissolution characteristics of furosemide are improved in tablets made from the kneaded product. By this means an essentially quicker effect can be achieved, a lower drug quantity is necessary for a similar effect, a smaller therapeutic risk in involved, and the technique is economical too.

Cyclodextrins↗
PubMed1981

[Studies on the mixing and the stability of diphenhydramine-containing powders (author's transl)].

The anti-allergic agent diphenhydramine (Dimedrol) is of poor mixability. Mixing is facilitated by the addition of 2.5--5% Aerosil 380 or of only 0.5--1% Aerosil 200 and R 972. The volume of weight of the powder mixtures is increased by adding 0.5% of any of these adjuvants, and the angle of inclination is considerably reduced by the addition of 0.5--1%. Flowable mixtures are obtained only with Aerosil 380 and R 972. Stability was best in mixtures containing 2.5--5% Aerosil 380. Such mixtures are most suited with regard to mixability and stability.

Diphenhydramine↗