Increased levels of plasma vitronectin in severe psoriatic patients.
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Adolescent↗
Biomedical subjects
M Kawashima
Publications and source records attributed to M Kawashima.
Molecular cloning of a novel human papillomavirus (type 60) from a plantar cyst with characteristic pathological changes.
In a plantar cyst composed of the wall of the squamous cell layer and the horny inner substance in the lower dermis, we found characteristic pathological changes, such as cytoplasmic eosinophilic inclusions and vacuolated structure, and, immunohistochemically, the papillomavirus capsid antigen. The human papillomavirus (HPV) DNA cloned from the cyst showed no homology with other known prototypes of HPV (HPV 1 through HPV 59) by Southern blot analysis under stringent conditions and was named as HPV 60. HPV 60 DNA was found in three other cases of plantar cyst with the identical pathological changes, but not in a plantar cyst without such changes. The results suggest that HPV 60 has unique biological properties to induce a plantar cyst as a distinct type of cutaneous HPV.
Blotting, Southern↗
Comparative study of Ki-67 immunostaining and nuclear DNA content in histiofibrous tumors.
A comparative assessment was made of dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma. The study was comprised of an immunohistochemical investigation using the Ki-67 monoclonal antibody and a quantitative analysis of cell nuclear DNA using flow cytometry. It was found that the index of Ki-67 monoclonal antibody labeling, the histogram pattern, and DNA index correlated with clinical malignancy, suggesting the usefulness of these indices for differential diagnosis and evaluation of prognosis.
Adult↗
Basal cell carcinoma arising on the ear of a young adult.
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Adult↗
A case of lymphadenosis benigna cutis of the earlobe: an immunohistochemical study.
We report a 38-year-old woman who developed an erythematous nodule on her earlobe after wearing pierced-type 18-carat gold earrings. Biopsy specimens revealed dense cellular infiltration predominantly composed of lymphocytes and plasma cells in the dermis and subcutaneous tissue with formation of lymph follicles. Morphological and immunohistochemical analyses were compatible with lymphadenosis benigna cutis.
Adult↗
The coexistence of psoriasis vulgaris, Sjögren's syndrome, and Hashimoto's thyroiditis.
A 52-year-old woman presented with psoriasis vulgaris, Sjögren's syndrome, and Hashimoto's thyroiditis with a 5-year history. She had a number of immunological abnormalities and typical psoriatic plaques over her entire body. The relationship between psoriasis, Sjögren's syndrome, and Hashimoto's thyroiditis is discussed from the viewpoint of immunology, and similar cases in the literature are reviewed. This is the first report of a coexistence of psoriasis vulgaris, Sjögren's syndrome, and Hashimoto's thyroiditis.
Female↗
A case of contact dermatitis due to methylprednisolone.
A 46-year-old woman developed contact dermatitis on her face after application of an ointment containing 0.1% methylprednisolone and 0.35% fradiomycin. Her patch test result was positive with methylprednisolone, but not with fradiomycin. No cross-reactions were observed after conducting patch tests with 17 different topical corticosteroids including prednisolone.
Dermatitis, Allergic Contact↗
The coexistence of eruptive vellus hair cysts and steatocystoma multiplex.
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Adult↗
Epidermodysplasia verruciformis.
Epidermodysplasia verruciformis is a rare skin disease characterized by the disseminated, flat, wart-like lesions caused by human papillomavirus and a high frequency of various skin cancers. The clinical aspects, histological findings, genetic and immunological factors, and human papillomavirus types found in the disease and their roles in skin cancers are reviewed.
Epidermodysplasia Verruciformis↗
Langerhans-cell histiocytosis in an adult patient with multiple myeloma.
A 44-year-old man who had suffered for 6 years from multiple myeloma developed multiple papules on the face and chest. Histological examination of these papules revealed the infiltration of predominantly histiocytic cells into the dermis and into parts of the epidermis. These cells were seen on electron-microscopic study to have Langerhans granules in the cytoplasm, which led to a diagnosis of Langerhans-cell histiocytosis concomitant with multiple myeloma. Possible explanations for this unusual association are discussed.
Adult↗
Pelgeroid-like anomalous cells in the diagnosis of neutrophilic dermatosis associated with myelodysplastic syndrome.
Neutrophilic dermatoses (ND), with or without accompanying myelodysplastic syndrome (MDS), were examined in terms of nuclear abnormality like pelgeroid anomaly of infiltrating cells into skin lesions. Six ND accompanying MDS showed 1.0 to 13.5% of such anomalous cells among infiltrating cells. In contrast, ND without accompanying myeloproliferative disorders rarely had such anomalous cells. Our findings suggest that pelgeroid-like anomalous cells infiltrating into ND are probably a good marker of underlying MDS.
Aged↗
Psoriasiform sarcoidosis with ulceration.
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Adult↗
Arginine vasotocin binding component in the uterus (shell gland) of the chicken.
The plasma membrane fraction of the uterus of the chicken was found to contain a component that shows specific binding to arginine vasotocin (AVT), arginine vasopressin (AVP) and oxytocin (OT). This binding component possesses a higher affinity to AVT than to AVP or OT, and the affinity to AVT was higher in laying hens than in non-laying hens and immature pullets, while the maximum number of binding sites per mg protein was less in the laying hens. Intramuscular injections of either estradiol-17 beta, progesterone or testosterone into the immature pullets for six consecutive days caused an increase in the affinity and number of binding sites. The results suggest that AVT receptors are present in the chicken uterus and that their binding properties are affected by ovarian steroid hormones.
Animals↗
Enhancement of progesterone receptor bindings by estradiol in pituitary cells of the hen.
Isolated cells from pituitaries of nonlaying hens were incubated in vitro with and without estradiol-17 beta (E2), and the amount of progesterone receptor binding in the cytosolic fraction of the cells was measured by an exchange assay. When the cells were incubated with 1.0 ng E2 for 1, 2, or 4 h, the progesterone receptor bindings were increased. The bindings were not increased when incubated together with cycloheximide, actinomycin-D, or alpha-amanitin. The results suggested that the cytosolic progesterone receptor binding of pituitary cells was enhanced by the action of estrogen through a protein-synthesizing pathway.
Animals↗
Luteinizing hormone-releasing hormone receptor bindings of the hen pituitary: difference between laying and nonlaying hens, effects of ovarian steroid hormones in vivo, and changes during an ovulatory cycle.
The equilibrium dissociation constant (Kd) of the pituitary luteinizing hormone-releasing hormone (LHRH) receptors and the maximum binding capacity (Bmax) per milligram of membrane protein were greater in laying hens than in nonlaying hens. A single i.m. injection of progesterone, estradiol-17 beta, or 5 alpha-dihydrotestosterone into nonlaying hens caused an increase in Kd and Bmax values. During an ovulatory cycle of the laying hen, Kd and Bmax values decreased from 16 to 14 h and 8 to 6 h before ovulation. A decrease in the Bmax value was also found 24 to 21 h before ovulation. A single i.v. injection of chicken LHRH-I caused a decrease in the Kd and Bmax values within 2 min after the injection. The results suggest that the hen pituitary LHRH receptor bindings are affected by ovarian steroid hormones and that their changes during the ovulatory cycle may relate to the release of a gonadotropin from the pituitary.
Animals↗
Effect of progesterone in vitro on luteinizing hormone production in hen pituitary cells pretreated with estrogen.
Isolated cells from the pituitary gland of nonlaying hens were preincubated in vitro with or without estradiol-17 beta (E2), and then incubated with or without progesterone (P4), and luteinizing hormone (LH) in the cells and media was measured by a homologous radioimmunoassay. When the cells were preincubated with E2 for 2 h and then incubated with P4 for 4 h, cellular LH was increased, but LH in the medium remained unchanged. The increase in cellular LH in response to P4 was dose-dependent. Protein synthesis inhibitors (cycloheximide, actinomycin-D, and alpha-amanitin) blocked the response of the cells to P4. The results suggest that LH production in estrogen-primed pituitary cells of the hen was stimulated by P4 through a protein-synthesizing pathway.
Animals↗
[A case of cardiac sarcoidosis associated with various clinical symptoms and thrombocytopenia].
A 29-year-old man presented with acute onset of high fever, chest pain and dyspnea. Chest X-ray film showed diffuse interstitial shadows, a cavitary lesion in the left upper lung field and cardiomegaly, but no lymphadenopathy. Abdominal CT scan showed hepatosplenomegaly and multiple small low density areas in the liver and spleen. Electrocardiogram demonstrated multifocal ventricular premature beats and ventricular tachycardia. Cardiac catheterization revealed left ventricular aneurysms. Sarcoidosis was confirmed by lung and liver biopsy. Drug therapy of prednisolone and mexiletine resulted in clinical improvement of symptoms, signs and chest X-ray film, but platelet count decreased gradually. It is suggested that an immune mechanism of sarcoidosis may have been the cause of this thrombocytopenia.
Adult↗
[The sequential changes of serum acute phase reactants in response to antituberculous chemotherapy].
In order to evaluate the clinical effectiveness of response to antituberculous chemotherapy, we measured the serum levels such of acute phase reactants as C-reactive protein (CRP), alpha-1-acid glycoprotein (alpha 1-AG), haptoglobin, alpha-1-antitrypsin (alpha 1-AT) and sialic acid in 24 patients with pulmonary tuberculosis. Furthermore the relationship between these parameters and other biochemical indicators, such as serum immunoglobulins (IgG, IgA and IgM) and blood erythrocyte sedimentation rate (ESR) were observed. In the case studies of the eighteen prognostically cured patients, the serum levels of alpha 1-AG, haptoglobin, alpha 1-AT and sialic acid were significantly higher than those of healthy controls (P less than 0.01), and were significantly decreased to normal levels within three to five weeks after negative results for tubercule bacilli were obtained in the sputum cultures, while CRP, immunoglobulin and ESR showed a tendency to be lower than the healthy controls. In conclusion, alpha 1-AG, haptoglobin, alpha 1-AT and sialic acid are considered to be the sensitive biochemical indicators capable of being used to predict and monitor the clinical response to antituberculous chemotherapy.
Acute-Phase Proteins↗