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Biomedical subjects

M Kayser

Publications and source records attributed to M Kayser.

65 records · Page 4Linked to original sources
PubMed1985

[Experiences in the use of pedicled muscle flaps in reconstructive accident surgery].

The one year-experience with muscle and musculocutaneous flaps in 16 patients with 18 flaps in different regions of the body is represented. The indications were open fractures with extensive loss of soft tissue, infectious complications after joint-replacement or osteomyelitis, defects after tumor resection or irradiation therapy and decubital ulcers. In 11 patients there was a satisfactory result. Complications with partial loss of the flap resulted from primary transposition in open fractures with marked contusion of the muscle, neglection of the specific vascularisation pattern or irradical necrectomy. Viewing the relatively simple operative techniques with muscle and musculocutaneous transposition or island flaps, free microvascular tissue transfer may be unnecessary in many situations.

Amputation, Traumatic↗
PubMed1981

The influence of different modes of immunization on the experimental genital herpes simplex virus infection of mice.

Previous investigations, which simulated the usual sequence of the human Herpes simplex virus (HSV) infections, had shown that the oral infection of mice with HSV-1 caused only weak protection from genital infection with HSV-2, although the course of infection was attenuated and lethality diminished. This heterologous, heterotopic model was compared with a homologous, heterotopic and a heterologous, homotopic model. The results did not differ very much, although the homologous immunization protected best from lethal outcome, the homotopic immunization best from local infection. Three different preparations of a killed vaccine from purified HSV-1 virion had little effect on the course of the local infection, although protection from lethal outcome was as good as with live virus. In contrast, a crude UV-inactivated vaccine protected nearly completely from local infection. Latent infection in the lumbosacral ganglia was significantly inhibited by immunization with live virus, but only slightly prevented by killed vaccine. The prevalence of latent infection correlated with the extent of vaginal infection. The results show that neither the viral type nor the inoculation site used for immunization with live virus are very critical. Moreover, they allow the conclusion that generalized type-dependent immune factors seem to be engaged in protection against lethal disease; these may be circulating humoral antibodies. On the other hand, locally induced immune factors (probably cellular) are apparently of prime importance for the protection from acute local and latent ganglionic infection.

Animals↗