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Biomedical subjects

M Kelly-Hayes

Publications and source records attributed to M Kelly-Hayes.

29 records · Page 2Linked to original sources
PubMed1994

The effects of specific medical conditions on the functional limitations of elders in the Framingham Study.

OBJECTIVES: The purpose of this study was to identify associations between specific medical conditions in the elderly and limitations in functional tasks; to compare risks of disability across medical conditions, controlling for age, sex, and comorbidity; and to determine the proportion of disability attributable to each condition. METHODS: The subjects were 709 noninstitutionalized men and 1060 women of the Framingham Study cohort (mean age 73.7 +/- 6.3 years). Ten medical conditions were identified for study: knee osteoarthritis, hip fracture, diabetes, stroke, heart disease, intermittent claudication, congestive heart failure, chronic obstructive pulmonary disease, depressive symptomatology, and cognitive impairment. Adjusted odds ratios were calculated for dependence on human assistance in seven functional activities. RESULTS: Stroke was significantly associated with functional limitations in all seven tasks; depressive symptomatology and hip fracture were associated with limitations in five tasks; and knee osteoarthritis, heart disease, congestive heart failure, and chronic obstructive pulmonary disease, were associated with limitations in four tasks each. CONCLUSIONS: In general, stroke, depressive symptomatology, hip fracture, knee osteoarthritis, and heart disease account for more physical disability in noninstitutionalized elderly men and women than other diseases.

Activities of Daily Living↗
PubMed1992

Functional limitations and disability among elders in the Framingham Study.

BACKGROUND: The measurement of physical disability as an indication of the impact of disease is commonly seen in research. However, these measures often do not clearly differentiate between functional limitations and daily performance of an activity. METHODS: We measured the differences between self-reported disability and observed functional limitations in six activities of daily living tasks among community-dwelling elders. The value of functional limitations vs disability measures in determining risk factors for disablement was ascertained. RESULTS: Systematic differences were found among the 1453 participants. At least 89% of the time when a difference was identified, the subjects ranked disability greater than the functional limitations observed. For those who were cognitively impaired, discrepancies occurred up to 11% of the time. In determining risk factors for disablement, we found that neurological impairments were associated with both functional limitations and disability, while sociocultural factors were associated with disability only. CONCLUSIONS: Our findings suggest that physical functional limitations and disability in the elderly are two distinct concepts and that the measure of choice should be determined by research objectives and the type of population being studied.

Activities of Daily Living↗
PubMed1991

A preventive approach to stroke.

There is reason to believe that continued attention to and modification of stroke risk factors will yield major dividends in disease prevention. It will be through the united efforts of health professionals that we can extend the continued success demonstrated in the current decline seen in stroke occurrence and disability. Nursing professionals contribute to preventive interventions by promoting positive health attitudes and applying prevention strategies in their personal lives and clinical practice.

Alcohol Drinking↗
PubMed1989

Prevalence of silent stroke in patients presenting with initial stroke: the Framingham Study.

It is common to find computed tomography scan evidence of prior stroke without a history of such an event. The frequency, risk factors for, and relevance of silent strokes are unknown. The Framingham cohort of 5,184 men and women aged 30-62 years and free of stroke at entry to the study have been followed with periodic examinations since 1950. We studied the silent strokes found on computed tomography scan of all initial strokes that occurred between January 1, 1979, and July 31, 1987. During these 8 1/2 years, 164 initial strokes occurred; 124 had computed tomography scans performed. There were 13 (10%) with silent stroke, 71 had abnormalities related to their presenting acute stroke, and 40 had normal computed tomography scans. There were 15 silent lesions; eight were lacunar infarcts in the basal ganglia-internal capsule area, seven were small cortical infarcts. Glucose intolerance was the sole risk factor that occurred significantly more frequently (11 of 13) in the group with silent lesions (p less than 0.04) than in the group with computed tomography evidence of acute stroke. Silent stroke is not rare; it was present in at least 10% of acute initial stroke patients arising in a general population. The relation of these silent lesions to the development of "vascular" dementia and poststroke disability deserves further study.

Cerebral Infarction↗
PubMed1988

Factors influencing survival and need for institutionalization following stroke: the Framingham Study.

The distinction between factors that influence survival after stroke and those that increase the likelihood of institutionalization is an important health issue. Estimates of survival and frequency of institutionalization after stroke vary widely, depending on the patient population. A precise picture of variability of outcome from stroke may be obtained from a prospective epidemiologic study. This report uses the Framingham Study population sample of 5,184 men and women, aged 30 to 62 at entry in 1948, who were free of cardiovascular disease. All completed strokes that occurred between 1971 and 1981 were evaluated. Of the 213 patients with completed strokes, 154 survived more than 30 days. Multivariate logistic regression analysis indicated that acute survival was negatively influenced by stroke type, severity of neurologic impairment, and age. For those who survived at least 30 days, independent living was determined by social factors as much as by severity of disability. Being married protected men but not women from institutionalization. Older women, married or not, with moderate to severe residual impairment and minimal education, were at highest risk of institutionalization. In acute stroke, medical factors dominated rates of survival. However, in those who survived, family and social factors had an equal impact in determining final outcome from stroke.

Activities of Daily Living↗
PubMed1986

The Stroke Data Bank project: implications for nursing research.

The Stroke Data Bank (SDB) is a systematic prospective study of the diagnosis, clinical course, and outcome of a large series of stroke cases. The SDB uses an interdisciplinary approach, with neurologists, nurse clinicians, epidemiologists, statisticians, and computer scientists collaborating to study stroke research issues, including diagnosis of stroke subtypes, characterization of the course and outcome of each stroke type, and identification of nonclinical factors that influence outcome. Research questions germaine to nursing management of stroke patients include: the identification of acute stroke patients likely to develop life-threatening or recovery-impeding complications; assessment of the impact of stroke on ability to perform activities of daily living; determination of how depression affects functional recovery; and identification of quantifiable measures of stroke outcome.

Activities of Daily Living↗
PubMed1980

Is L-DOPA drug holiday useful?

We studied 9 patients with severe, chronic Parkinson disease and complications of long-term L-DOPA therapy. After a "holiday" of 3 to 21 days, excess dopamine effects improved in all patients, and the baseline parkinsonian picture emerged. After reinstitution of L-DOPA therapy, often at lower doses than had been used previously, parkinsonian signs improved. Complications of immobility were seen in two patients; one had deep vein thrombophlebitis, and the other became depressed. In treating the individual patient, the risks of immobility despite aggressive attempts to prevent complications should be weighed against the possible improvement of parkinsonism. These findings suggest that a holiday from L-DOPA therapy may extent the drug's usefulness in treating Parkinson disease, perhaps by resensitizing striatal dopamine receptors in patients receiving the drug for prolonged periods.

Activities of Daily Living↗
PubMed1979

Peripheral neuropathy in arsenic smelter workers.

We conducted a double-blind controlled study of individuals exposed to arsenic trioxide in a copper-smelting factory. Subjects fell into three categories of peripheral neuropathy: none, subclinical, and clinical. The subclinical group had no symptoms or signs of numbness or reduced reflexes, but did have reduced nerve conduction velocity and amplitude measurements. Clinical neuropathy groups had signs and symptoms of neuropathy and electrophysiologic abnormalities. The clinical and subclinical groups correlated with increased content of arsenic in urine, hair and nails. The incidence of subclinical and clinical neuropathy was greater in arsenic workers than in unexposed controls.

Adult↗
PubMed1978

Baclofen for spasticity in multiple sclerosis. Double-blind crossover and three-year study.

Baclofen is a safe and effective means for treating spasticity associated with multiple sclerosis. We found no toxic effects on hepatologic, hematopoietic, or renal function, acutely or for over 3 years of follow-up. A statistically significant reduction was noted in frequency of spasms, and clonus, and there was improved range of joint movement, which enabled patients to maintain functional status for prolonged periods. For the more disabled patients, treatment with baclofen gave symptomatic relief of painful spasms and made immobility more tolerable. Optimum effect was achieved when baclofen was administered in the early stages of disease, before major disabilities became permanent.

Activities of Daily Living↗