Biomedical subjects

M Kh Andreeva

Publications and source records attributed to M Kh Andreeva.

3 recordsLinked to original sources

PubMedDate not supplied

[Recurrent adenoma of the hypophysis].

Adenoma recurrences were established in 24 (9.7%) of 247 patients with operated pituitary adenomas; 7 of them were with chromophobic non-secreting adenomas, 9 patients with acromegaly, 5 female and 3 male patients were with prolactinomas. Transcranial operations were performed on patients with large-size tumors and transsphenoidal ones on patients with small-size adenomas. Our experience has shown that adenoma recurrence was more frequent in larger tumors. Our results are supported by those of other authors. Early diagnosis and surgical treatment of pituitary adenomas prevent their recurrences.

Adenoma↗

PubMedDate not supplied

[Pituitary apoplexy].

Ten patients with pituitary apoplexy were treated at the Institute of Endocrinology, Gerontology and Geriatrics in Sofia over the last 5 years. They represented 5.06% of the total number of patients with pituitary adenomas treated at the Institute during the same period. The highest frequency of pituitary apoplexy was noted among patients with Nelson's syndrome. In 5 patients of this group pituitary apoplexy was the first sign of a tumor. Headaches combined with nausea and vomiting were the earliest symptoms of pituitary apoplexy, and ptosis and ophthalmoplegy were the most common symptoms in the patients. The disease was not correctly diagnosed in 7 patients who immediately after apoplexy were treated in neurological and ophthalmological departments.

Adolescent↗

PubMedDate not supplied

[Treatment of Cushing's syndrome with large doses of reserpine].

The effectiveness of high doses of reserpine was studied in two groups of patients, suffering from Icenko-Cushing's disease. The patients of the first group received gamma-beam therapy combined with high doses of reserpine. The patients of the second group were treated with gamma-beam radiation associated with unilateral adrenalectomy plus high doses of reserpine. The controls were treated as described above, but without reserpine use. The results obtained have shown that reserpine monotherapy is not recommended in Icenko-Cushing's disease. High doses of reserpine combined with gamma-beam radiation alone or coupled with unilateral adrenalectomy shortened the period of the appearance of remission. The arterial blood pressure was significantly lower in patients treated with high doses of reserpine.

Adolescent↗