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Biomedical subjects

M Khlat

Publications and source records attributed to M Khlat.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Life style and health behavior of southern European and North African immigrants in France].

Using data from a French national survey, preventive and dietary habits, alcohol and smoking consumption of three groups of migrants (Italy, Spain and Portugal, Maghreb) were compared to those of French nationals. Odds ratios were estimated using a logistic regression, after adjustment by age, socio-professional group and place of residence. Differences in attitude were observed, in particular: lower primary and secondary practice of prevention; lower consumption of meat and dairy products and higher consumption of starchy food and dried vegetables; lower consumption of alcohol and higher tobacco intake among Maghrebian migrants. The observed differences were interpreted in the light of other available data in France. They confirm notably imported dietary habits and a weaker perception of preventive messages, as shown in other studies.

Adolescent↗
PubMed1994

Cancer mortality among Chinese and South-East Asian migrants in France.

The cancer risk in migrants from China and South-east Asia (Vietnam, Laos and Cambodia) resident in France has been compared to that observed in the local-born population, using mortality data from the period 1979-1985 and population data from the 1982 French census. Risks were adjusted for important confounding factors such as social standing and area of residence. Compared to local-born, South-east Asian migrants of one sex or both sexes combined have higher risks of cancer of the nasopharynx, stomach, liver, gallbladder, lung (in females only), and cervix. On the other hand, South-east Asian migrants have lower risks of cancer of the oral cavity, other pharynx, colon, rectum, larynx, lung (among males only), bladder, nervous system, breast and prostate. Within this group, the risks are quite similar for Vietnamese, Laotians and Cambodians. Results for Chinese-born migrants are quite similar, for most sites, to those found among South-east Asian migrants, although, because of smaller numbers, few of the estimates are statistically significant. These results are consistent with other studies on Chinese migrants around the world, and with the 3 other previous studies on Vietnamese migrants, in England and Wales, Los Angeles and Australia.

Asia, Southeastern↗
PubMed1993

Cancer risks among European migrants in São Paulo, Brazil.

Using both mortality and incidence data, cancer risk in Italian, Spanish and Portuguese migrants to São Paulo were compared with those in the Brazil-born population, and with those in their countries of origin. Italian and Spanish migrants show changes in cancer risks which are rather similar to those observed in migrants of the same origin in other parts of South America: they increase their rates of oropharyngeal, oesophageal, cervical and breast cancers and they decrease their rates of lung cancers. However, for cancer of the oesophagus, the changes are greater in São Paulo, where migrants acquire rates similar to those of the natives. For colon cancer, rates in Italian migrants decrease in the low risk area of São Paulo and increase in the high risk area of Argentina. Changes in Portuguese migrants are less evident: their rates of colorectal cancer remain high, and, as found for Japanese migrants in São Paulo, they also retain their higher risks of stomach cancer.

Adult↗
PubMed1993

Education and mortality from cancer in São Paulo, Brazil.

This study investigated social class differentials in cancer mortality in São Paulo county, Brazil, for the period 1978 to 1982. A measure of socioeconomic status based on education was used, and cancer risk by level of education was estimated by a case-control approach in which other cancers were considered as controls. For most cancers, the socioeconomic differences in risk were similar to those found in western Europe and North America. For lung cancer, however, the highest risk was observed in men and women with the most education. Other cancers related to tobacco--cancer of the larynx, pharynx, and esophagus--showed a negative association with education. The differences between social classes in consumption habits of alcohol and maté and the use of black tobacco are probably responsible for these contrasting patterns. For breast and cervix uteri cancer the social class patterns were similar to those found in developed countries--a positive relationship for breast and a negative one for cervix uteri cancer. The magnitude of the differences observed between social classes for these cancers was frequently greater in South America than in the United States or western Europe.

Adult↗
PubMed1993

[Cancer mortality in immigrants from the Near East in Australia].

A differential mortality study shows that in Australia, between 1969 and 1983, Near Eastern migrants had a lower cancer mortality than the local-born, and that their cancer profile resembled that of the other mediterranean migrants in Australia. Compared to local-born, Near Eastern migrants were characterized by: (1) a lower mortality from oesophagus and colon cancers, and from melanoma, in both sexes, from prostate cancer in men borne in males, from ovary and bladder cancers in females; (2) a higher mortality from liver and thyroïd cancers in males, and from stomach and gallbladder cancers in females. The analysis by country of birth indicates a higher mortality from lung and bladder cancers in men born in Turkey, a lower mortality from lung cancer in men born in Syria or Lebanon, and a lower mortality from breast cancer in women born in Syria or Lebanon. These differences are interpreted in the light of the available information on dietary habits and reproductive behaviour of Near Eastern migrants in Australia.

Adolescent↗
PubMed1992

Mortality from melanoma in migrants to Australia: variation by age at arrival and duration of stay.

All death records in Australia during the period 1964-1985 were analyzed to compare mortality from melanoma in immigrants and Australian-born individuals, and to investigate changes in risk in the immigrants according to their duration of stay and age at arrival. About 450,000 deaths were from cancer, and risks of melanoma were estimated by logistic regression relative to those of the Australian-born, with deaths from other cancers used as controls. Estimates were adjusted for age at death, time period, birth cohort, and state of registration of death in Australia. Region of birth was defined as New Zealand, other Oceania, England, Ireland/Scotland/Wales (including Northern Ireland and the Republic of Ireland), Central Europe, Eastern Europe, Southern Europe, Western Asia, or Eastern Asia, bearing in mind that many migrants born in Asia were of European descent. Overall, migrants from outside Oceania were at lower risk than the Australian-born, and the lowest risks in males were in Southern Europeans and Eastern Asians, reflecting the protective effect of a darker complexion. Risk of melanoma was related both to duration of stay in Australia and to age at arrival; although their relative importance cannot be measured, the patterns of change suggested that childhood migration may be more important in determining risk than number of years in Australia. The authors believe this study to be based on the largest data set ever used in migrant studies, and note that the previously found differences in melanoma risk between immigrants and Australian-born remained after adjustment for major temporal and geographic confounders. The results confirm the importance of the interaction between environmental and genetic risk factors in the etiology of melanoma.

Age Factors↗
PubMed1992

The natural history of lung cancer estimated from the results of a randomized trial of screening.

The results from a randomized controlled trial of screening for lung cancer in Czechoslovakia have been used to estimate parameters of the natural history, using a model to simulate the disease process and the effects of screening. The results suggest that the period before clinical presentation during which lesions can be detected by screening is very short (seven to eight months). This implies that to detect three-quarters of all lung cancers by screening, two examinations per year are necessary, and that such a program would advance diagnosis by six months if there were complete participation. The results of the trial itself suggest that the benefit, in terms of a reduction in mortality from lung cancer, is likely to be very small.

Adult↗
PubMed1991

Cancer in migrants to Argentina.

Mortality rates from different cancers in migrants to Argentina from 11 individual countries and 6 groups of countries were compared with those in the Argentina-born population and in their countries of origin. Almost all countries of origin had higher mortality rates from gastric cancer than Argentina, but the risk declines in migrants, and for European migrants becomes similar to that of the Argentina-born. In contrast, mortality from oesophageal cancer is significantly lower in European countries than in Argentina. For cancer of the colon and breast, most countries have lower mortality rates than the Argentina-born, the exceptions being Uruguay and Germany, and migrants demonstrate a convergence of risk towards that of Argentina-born. These results suggest that migrants to Argentina undergo changes in some environmental exposure, probably dietary, which give rise to substantial alterations in cancer risk within their lifespan.

Argentina↗
PubMed1991

The role of infection by Opisthorchis viverrini, hepatitis B virus, and aflatoxin exposure in the etiology of liver cancer in Thailand. A correlation study.

The incidence of the two principle types of liver cancer (hepatocellular carcinoma and cholangiocarcinoma) in five different areas of Thailand was compared with the prevalence of exposure to the main risk factors in samples of the population. Cholangiocarcinoma showed striking variations in incidence, which correlated closely with markers of exposure to the liver fluke, Opisthorchis viverrini. However, there was little geographic variation in incidence of hepatocellular carcinoma or in prevalence of the major risk factors (chronic carriage of hepatitis B virus and exposure to aflatoxin), and apparently there was little relationship between them.

Adenoma, Bile Duct↗
PubMed1991

Opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in Thailand.

Cholangiocarcinoma (CCA) is one of the most common cancers in north-east Thailand and has been associated with infestation by the liver fluke Opisthorchis viverrini (OV). Two samples of 12-hr overnight urine (after dosing with proline and ascorbic acid or proline alone) were collected from 20 inhabitants from each of 5 contrasting incidence areas for CCA. The incidence of CCA was not correlated with either the amount of NPRO or other nitrosamino acids, endogenous nitrosation potential (difference in NPRO levels between proline dose and proline and ascorbic dose), or nitrate level. However, when urinary levels of nitrosamino acids were compared in subjects living in high-risk areas, subjects who were positive for OV antibody excreted significantly more (p less than 0.01) NPRO (12.3 +/- 18.7 micrograms/12 hr) after proline ingestion than those who were negative (3.5 +/- 3.2 micrograms/12 hr). After ingestion of ascorbic acid, the NPRO levels in the positive subjects were significantly reduced (p less than 0.01) to 2.4 +/- 2.0 micrograms/12 hr, suggesting that endogenous nitrosation of proline was inhibited. Thus, endogenous nitrosation potential estimated from the difference between NPRO and the sum of nitrosamino acids excreted in the 2 urine samples was significantly higher in subjects positive for the OV antibody. Small amounts of pre-formed nitrosamines were found in fermented fish and pork food items, which are consumed frequently in the high-risk area for CCA. These results suggest that the interaction between chemical carcinogens, especially nitrosamines, and OV infestation may play a role in the development of cholangiocarcinoma in Thailand.

Adenoma, Bile Duct↗
PubMed1991

Liver cancer in Thailand. I. A case-control study of cholangiocarcinoma.

Potential risk factors for cholangiocarcinoma were investigated in a case-control study among inhabitants of north-east Thailand, which included 103 cases from 3 hospitals, with age- and sex-matched controls. A clear association with past or present infection with Opisthorchis viverrini, as indicated by raised serum antibodies, was found (o.r. 5.0), and at least two-thirds of cases can be attributed to this cause. The results suggest that males may be at higher risk than females. There was no association with hepatitis B infection, with aflatoxin intake as estimated from albumin adducts in serum or with any particular dietary patterns. Alcohol consumption was very low in the population, and the risk associated with regular drinking was non-significant. Regular users of betel nut-predominantly female-had a high risk (o.r. 6.4), a possible mechanism being through their increased exposure to nitrosamines.

Adenoma, Bile Duct↗
PubMed1991

Liver cancer in Thailand. II. A case-control study of hepatocellular carcinoma.

Potential risk factors for hepatocellular carcinoma were investigated in a case-control study among inhabitants of north east Thailand. Sixty-five cases from 3 hospitals, with matched controls, were included. Infection with hepatitis-B virus was the major risk factor-chronic carriers of HB surface antigen had an estimated relative risk of 15.2. Infection with hepatitis-C virus appeared to be rare. No increase in risk was found with recent aflatoxin intake, as estimated by consumption of possibly contaminated foods, or by measuring aflatoxin-albumin adducts in serum. Regular use of alcohol (2 or more glasses of spirits per week) was associated with a non-significant elevation in risk (o.r. = 3.4, 95% c.i. 0.8-14.6), but the number of regular drinkers in the population was small. The meaning of an apparent protection conferred by certain food items is uncertain, but a possible role of betel nut in the aetiology deserves further investigation.

Adolescent↗
PubMed1991

Cancer in Italian migrants.

Migration of Italians to other parts of the world has a long history and has involved very large numbers of individuals. The study of the health consequences of this migration is made possible by the availability of statistics on mortality and morbidity, both in Italy and in the host countries, and of social and economic information on the various Italian communities abroad. The results of the major studies are reviewed, comparing the rates in immigrants with those in the host countries and in Italy. The differences in cancer rates between Italian and local-born populations--for stomach cancer in both sexes, and for cancer of the colon, lung, and breast in females, and for prostate cancer--are consistent with the direction of differences between rates in Italy and those in the host countries. For colon and rectum cancer in males, there are unexpected findings in most of the United States' studies. Analysis by duration of residence shows changes in the risk for several sites in males, but not in females, according to length of stay in the host country. This finding possibly reflects greater stability of habits and lifestyle in females compared to males.

Australia↗