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Biomedical subjects

M Khoury

Publications and source records attributed to M Khoury.

At least 37 records · Page 2Linked to original sources
PubMed1994

Chronic illness in Lebanese preschoolers: impact of illness and child temperament on the family.

The impact on their families of chronic illness in young Lebanese children and the relationship between such impact and perceived temperament of the child were assessed. The effect was greater in families of children with leukemia than in families of children with congenital heart defects. Chronically ill children were rated as more persistent/unstoppable, difficult, and irregular, and as less adaptable than were healthy children. Culturally determined perceptions of child temperament were examined with regard to differential impact of illness on the family.

Adaptation, Psychological↗
PubMed1994

Duplex-guided compression of iatrogenic femoral artery pseudoaneurysms.

The purpose of this report is to review our experience with duplex-guided compression in the management of iatrogenic femoral artery pseudoaneurysms. From February 1991 to July 1992, 13 consecutive asymptomatic femoral artery pseudoaneurysms were managed initially with duplex-guided compression. Twelve of these complications followed interventional cardiac procedures; the remaining case followed lysis of a femoral to tibial bypass. A Quantum Angiodynograph I duplex imager with a 5-MHz probe was used during this study. After the origin of the pseudoaneurysm was identified, compression was applied with the transducer head to obliterate flow in the pseudoaneurysm, while maintaining flow in the parent artery. Successful thrombosis was accomplished in 12 patients. The mean interval between the original femoral puncture and duplex-guided compression was 9.0 days (range, 1-22 days). The mean compression time was 30 minutes (range, 15-45 minutes). Pseudoaneurysm size ranged from 1.0 to 5.0 cm. Follow-up imaging, performed within 72 hours after compression, demonstrated sustained pseudoaneurysm thrombosis and patent femoral artery segments. Four patients were managed as out-patients, without the need for anesthesia or sedation. Eight patients were managed in the hospital, seven following interventional cardiac procedures, and one following bypass revision. Duplex-guided compression failed in one case. This patient was successfully treated operatively, at which time repair of both the profunda and superficial femoral artery was required. Asymptomatic iatrogenic femoral artery pseudoaneurysms can be successfully managed with duplex-guided compression. This maneuver appears to be a simple and cost-effective approach for initial management of these lesions.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1993

Disposal of outdated anti-infective products.

After an unsuccessful search for guidelines to destroy outdated anti-infective products, a procedure was developed for pharmacy that uses currently available biohazardous materials. By using a blood/body-fluid absorbent, an inexpensive waste system was developed to avoid the negative public sentiment caused by use of public landfills and avoid the risk of disposing waste in hospital drainage systems.

Anti-Infective Agents↗
PubMed1993

[Multicystic encephalomalacia in a surviving twin after death of the other twin in utero].

A case of multicystic encephalomalacia in a twin is reported. The other twin died in utero at 32 weeks gestational age. Because there was no evidence of fetal distress the pregnancy was allowed to continue until 36 weeks gestational age. Injuries to the surviving twin due to disseminated intravascular coagulation (DIVC) and vascular thrombosis or to anoxia and ischemia may occur when there are anastomoses between the circulatory systems of the two twins, i.e., in monochorionic pregnancies. The classically recommended strategy is to wait for adequate maturity of the surviving fetus (36 weeks). It is suggested that this attitude may be overly expectant and may deserve reappraisal.

Diseases in Twins↗
PubMed1992

Influence of arterial access sites and interventional procedures on vascular complications after cardiac catheterizations.

The purpose of this study is to define the incidence of complications at the arterial access site after cardiac catheterization. The influence of the arterial access site on these complications was identified, as were the clinical characteristics of these problems. A total of 8,797 cardiac catheterizations were performed over the 3-year period of this study. Diagnostic catheterizations and percutaneous transluminal coronary angioplasties (PTCAs) were included, and the arterial access site was identified. Diagnostic catheterizations were performed via the brachial artery (group I, n = 3,137) or the femoral artery (group II, n = 4,055). PTCAs were also performed via the brachial artery (group III, n = 32) or the femoral route (group IV, n = 1,573). Ninety-five major vascular complications occurred during the course of this study. The frequency of complications was higher with brachial artery catheterization when compared with the femoral route. PTCA was associated with a higher complication rate than diagnostic studies. Brachial artery complications were primarily arterial thromboses, which were easily diagnosed and treated. Femoral artery complications were more complicated, difficult to identify, and associated with significant morbidity.

Angioplasty, Balloon, Coronary↗
PubMed1991

Blood pressure in Ethiopian immigrants: relationship to age and anthropometric factors, and changes during their first year in Israel.

Blood pressure was measured in 483 Ethiopian immigrants during the first week following their arrival in Israel. Mean levels of diastolic (DBP) and systolic blood pressures (SBP) were very low compared with known levels in the Israeli population. BPs were elevated in men greater than 20 years old and in women greater than 40 years old. Quetelet index averaged below 2.00 g/cm2. Considerable weight gains were observed in 265 individuals examined after 1 year. Simultaneously, DBP increased by 4 mm Hg on average, whereas the changes in SBP were small. At the end of 1 year, the mean SBP ranged from 107 (age 5-9 and 10-14) to 124 mm Hg (age greater than or equal to 60) and mean DBP from 69 (age 10-14 and 15-19) to 78 mm Hg (age greater than or equal to 60), remaining nevertheless considerably lower than levels observed in diverse Israeli population groups. Covariance analysis revealed that initial BPs, gender, age, and weight gain significantly affected SBP and DBP at the end of the year.

Adaptation, Physiological↗
PubMed1989

Full skin thickness burns caused by contact with the pavement in a heat-stroke victim.

A 70-year-old woman, with a previous history of heat-stroke, suffered another heat-stroke on a hot summer day (air temperature 43 degrees C (109 degrees F)). She presented the rare complication of a heat-stroke plus deep burns sustained while lying unconscious on the pavement. In addition to age, obesity, previous illness, incidental fever, drugs, dehydration and physical effort, a previous history of heat-stroke is probably an important risk factor for a second heat-stroke. Burns from contact with the pavement are uncommon but possible, especially if the patient is obese, immobile and poorly insulated.

Accidents↗
PubMed1988

Effect of anti-cruciform DNA monoclonal antibodies on DNA replication.

To study the possible involvement of DNA cruciforms in the initiation of DNA replication, we used two monoclonal antibodies, 2D3 and 4B4, with anti-cruciform DNA specificity. Synchronized CV-1 cells were released into S phase for hourly intervals up to 6 h and permeabilized in the presence of monoclonal antibodies, under conditions that allow limited DNA replication. Exposure of the permeabilized cells to 2D3 or 4B4 resulted in a 2- to 6-fold enhancement of incorporation of labeled precursor nucleotide over the 6 h period. Approximately 50% of the enhanced synthesis was sensitive to aphidicolin, and the enhancing effect of 2D3 was abolished by absorption with immunobead anti-mouse immunoglobulin. Dot-blot hybridization analyses of DNA isolated from anti-cruciform antibody treatment groups showed a similar 2- to 11-fold increase in the relative copy number of low copy probes. In contrast, exposure of the permeabilized cells to a monoclonal antibody directed against Z-DNA and B-DNA had no significant effect on DNA synthesis. The results suggest that cruciforms are present in replicating DNA and that they are recognized and stabilized by the monoclonal antibodies.

Animals↗
PubMed1988

Infarction of the upper limbs associated with oligohydramnios and intrauterine compression.

We describe a case of neonatal infarction involving both upper extremities. Oligohydramnios, resulting in compression of both arms within the uterus, is proposed as the cause of this congenital gangrene. Despite attempted conservative management, both arms became flaccid and moist. By the third day of life, the infant's worsening cardiovascular status necessitated amputation. This rare disorder has varying degrees of presentation. Limbs have been salvaged with conservative management of the extremity, coupled with appropriate surgical intervention, and neonatal intensive care.

Adult↗
PubMed1986

Digital subtraction arthrography of the prosthetic hip.

Digital subtraction techniques are easily adapted to the evaluation of loosening in total hip prostheses, allowing real time review of injection dynamics and data manipulation after the study. We have successfully used both standard radiographic and digital imaging techniques in the evaluation of 15 prosthetic hip joints. The digital results are comparable to and often better than those of standard radiographic techniques for the evaluation of loosening in total hip prostheses.

Arthrography↗
PubMed1985

Calcification of entheses associated with X-linked hypophosphatemic osteomalacia.

We undertook a retrospective analysis of 26 patients with X-linked hypophosphatemic osteomalacia (or rickets), whose ages ranged from 1 to 62 years and who were from 11 different kindreds, to determine the prevalence and clinical characteristics of a unique disorder of the entheses (tendons, ligaments, and joint capsules). We found a generalized involvement of the entheses, with exuberant calcification of tendon and ligament insertions and of joint capsules, in 69 per cent of the subjects. The prevalence and extent of disease increased with age but were not correlated with sex. Commonly affected sites included the hand and sacroiliac joints. Histologic evaluation in a selected patient revealed intratendinous lamellar bone but no inflammatory cells. Our observations indicate that this disorder is an integral part of X-linked hypophosphatemic osteomalacia and exhibits clinical, radiographic, and histologic characteristics that differentiate it from degenerative disorders of these tissues and seronegative spondyloarthropathies.

Adolescent↗
PubMed1984

Obscured aortic arch on the lateral view as a sign of coarctation.

Forty patients with coarctation of the aorta were compared with 80 normal subjects matched by sex and age. The aortic arch was invisible on the lateral radiograph in 84% of patients preoperatively and 88% postoperatively. Only 6 normal subjects (8%) had a similar finding. The authors conclude that an obscured aortic arch on the lateral view could be a clue to the presence of coarctation. Possible explanations for this phenomenon include (a) dilatation of the brachiocephalic arteries (particularly the left subclavian artery), obscuring the superior margin of the arch; (b) hypoplasia and anteromedial displacement of the distal portion of the arch; and (c) diffuse hypoplasia of the arch combined with focal coarctation.

Adolescent↗
PubMed1980

[Echolalic repetition and severe comprehension disorders. Left hemisphere deactivation syndrome? (author's transl)].

An aphasic patient presented with suppression of spontaneous speech, correct repetition, and disturbed comprehension and denomination. The association of a lesion on CT scanning affecting the deep regions of the left hemisphere, and extinction of the right ear to dichotic audition, leads to a discussion of the role of the right hemisphere in remaining psycholinguistic capabilities.

Aphasia↗