Biomedical subjects

M Kindermann

Publications and source records attributed to M Kindermann.

40 records · Page 3Linked to original sources

PubMed1998

Bipolar active fixation atrial leads: comparison of two new lead models.

The purpose of the study was to examine the pacing and sensing characteristics of two bipolar active fixation atrial leads with a coaxial and a coradial conductor design, respectively. One group of ten patients received the ELA model S44F (4 mm2 vitreous carbon tip, coaxial multifilar coils, silicone). Nine other patients received the Intermedics ThinLine EZ 438-10 (8 mm2 iridium oxide-coated titanium tip, parallel-wound bifilar coil, polyurethane). Both lead models had electrically insulated corkscrews. Intraoperatively, pacing threshold (PT) at 0.50 ms, unfiltered atrial potential (AP), slew rate (SR) and pacing impedance (Z) at 2.5 V, 0.50 ms were measured using a Medtronic 5311 PSA. On the day of implant, and 2, 5, 10, 28, 90, 180, and 360 days after implant, minimum charge threshold (delta Qmin), atrial sensing threshold (Asen) and Z were measured via telemetry of the pacemaker (Intermedics 294-03 and 294-09). Z was significantly lower (P < 0.01) in the ThinLine EZ group at implant (419 omega vs 576 omega, mean values, 438-10 vs S44F) and at each follow-up (317-426 omega vs 492-613 omega). Five of nine patients with the 438-10 lead had Z values < 300 omega during follow-up (minimum 234 omega). There was no significant difference between the two leads with respect to PT (0.42 V vs 0.41 V), AP (3.75 mV vs 4.25 mV), SR (0.56 vs 1.06), delta Qmin (0.19-1.23 microC vs 0.18-1.35 microC) and Asen (3.4-4.5 mV vs 2.7-4.7 mV), respectively. Two patients developed pericardial effusions after implantation of a ThinLine EZ lead. One of them, who had a transient drop of blood pressure during implant, subsequently developed acute exsudative pericarditis. Therefore, both leads had acceptable sensing and pacing thresholds, but the 438-10 lead developed unusually low long-term lead impedance values. The high incidence of perforations in our small group of 438-10 patients has not been observed, thus far, in other studies.

Aged↗

PubMed1997

Optimizing the AV delay in DDD pacemaker patients with high degree AV block: mitral valve Doppler versus impedance cardiography.

In DDD-pacemaker patients with high degree AV block, Doppler echocardiography of transmitral blood flow can be used to find the individually optimal AV delay (AVO) for left heart AV synchronization. This study tried to validate a Doppler method (ECHO) recently proposed to optimize left ventricular filling by comparing it to stroke volume data derived from impedance cardiography (ICG). It should be further elucidated if optimizing the AV delay (AVD) by means of this method is superior to fixed AVD settings and which differential AVD (pace-sense-offset) should be programmed for atrially triggered (ATP) and AV sequential (AVP) pacing, respectively. AVO as measured in 53 patients showed a linear correlation between ECHO and ICG for both ATP (r = 0.66, P < 0.00001) and AVP (r = 0.53; P < 0.005). The mean deviation in AVO between ECHO and ICG was +/- 26 ms (ATP) and +/- 30 ms (AVP), respectively, with a tendency to longer AVDs with the Doppler method. ECHO limitations could mainly be attributed to: (1) restrictions of AVD programming options (which may be compensated for by slight modification of the proposal); and (2) to pathophysiological mechanisms that alter mitral valve dynamics. Optimization of the AVD by Doppler produced a stroke volume that was significantly higher (19%) than with a fixed AVD (150 ms in ATP; 200 ms in AVP). There was a wide scatter in pace-sense-offsets between-7 and 134 ms, which was reflected by both methods. It is concluded that AVO determinations by ECHO are valid provided that methodological pitfalls and limitations caused by the disease are recognized. Tailoring AVD with respect to diastolic filling improves systolic function and is superior to nominal AVD settings. Fixed differential AVDs as offered by some manufacturers are far from being physiological. Thus modern pulse generators should offer free programmability over a wide range of AV delays.

Atrioventricular Node↗

PubMed1996

Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells.

Signalling pathways determining the shear stress-induced production of NO from endothelial cells in situ were investigated using a bioassay system in which shear stress was increased by inducing vasoconstriction in an endothelium-intact donor segment (rabbit iliac artery) while maintaining a constant luminal perfusion rate. Shear stress-induced NO production, as assessed by changes in the tone of a preconstricted endothelium-denuded detector ring, was biphasic and consisted of an initial transient (20- to 25-minute) Ca(2+)-dependent phase followed by a Ca(2+)-independent plateau phase, which was maintained as long as the donor segment remained constricted. Stretching the donor segments to their in vivo length abolished the initial phase without affecting the plateau phase of NO release. Inhibition of the Na(+)-H+ exchanger using HOE 694 elicited an intracellular acidification which attenuated shear stress-induced NO production. The specific protein kinase C inhibitor, Ro 31-8220, was without effect, whereas the unspecific inhibitors, staurosporine and calphostin C, abolished the shear stress-induced production of NO. Erbstatin A, a tyrosine kinase inhibitor, attenuated the shear stress-induced tyrosine phosphorylation of specific cellular proteins and abrogated the associated NO production. In summary, these data indicate that shear stress activates the NO synthase at basal levels of [Ca2+]i via a mechanotransduction cascade that involves tyrosine phosphorylation and can be modulated by changes in pHi. The apparent fundamental alteration of the endothelial NO synthase under shear stress that renders its maintained activation independent of an increase in [Ca2+]i is probably the consequence of a change in the enzyme microenvironment.

Animals↗

PubMed1992

Threshold and polarization properties of modern active fixation atrial leads.

The purpose of the study was to compare the stimulation characteristics of two modern active fixation leads (Ela 583F, vitreous carbon tip [ELA] and Intermedics 82-0008-1601, iridium oxide tip [IROX]) with a standard lead (Osypka KY 67 VC, carbon-covered elgiloy tip [OSY]). In three groups of ten patients each, minimum charge threshold delta Qmin and polarization properties were determined via charge telemetry of the pacemaker (Intermedics Cosmos II and Relay) 0, 2, 5, 10, 28, 90, and 180 days after implant (dai). The polarization parameters global capacitance Cg, global resistance Rg, polarization voltage U(p), and a time constant t* (t* = Cg.Rg) were obtained by nonlinear regression. U(p) was always significantly (sig) lower in ELA and IROX (0.04-0.10 V) compared to OSY (0.54-0.76 V). Rg was sig lower in ELA (330-437 omega) compared to OSY and IROX (414-588 omega) from 0 to 28 dai. From 2 to 10 dai, Cg was sig higher in ELA and IROX (3.8-4.2 microF) compared to OSY (3.3-3.4 microF). In the three groups, delta Qmin reached a comparable maximum (1-1.2 microC) at 5 dai. Therefore, vitreous carbon and iridium oxide atrial fixation leads exhibit low chronic polarization effects compared to a standard elgiloy lead, but do not show a sig reduction in charge threshold.

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