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Biomedical subjects

M Kingsford

Publications and source records attributed to M Kingsford.

6 recordsLinked to original sources
PubMed1984

An in-vivo-in-vitro correlation for the bioavailability of frusemide tablets.

The dissolution behaviour of four commercial and two experimental formulations of frusemide tablets has been investigated using the USP rotating basket apparatus and pH 5.0 buffer at 37 degrees C as the test medium. There is a linear relationship between the percentage dissolution in 30 min and the bioavailability relative to an oral solution of frusemide over the bioavailability range 76-97%. Predicted bioavailabilities differed by no more than 2% from the measured values.

Biological Availability↗
PubMed1983

Discrimination between five oral frusemide preparations using renal chloride excretion and frusemide recovery.

The bioavailabilities of five preparations of frusemide (an aqueous solution, Diurin, Frusid, Lasix and Selemide tablets) were studied in healthy subjects, using Latin square designs and administering doses at weekly intervals. Relative to the solution, Lasix had reduced chloride excretion (0.88) and frusemide recovery (0.80) while Diurin and Frusid had reduced frusemide recoveries (0.90 and 0.92 respectively) There were no other significant differences. Potassium excretion tended to fall as the trials progressed.

Administration, Oral↗