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Biomedical subjects

M Kirchgessner

Publications and source records attributed to M Kirchgessner.

At least 379 records · Page 21Linked to original sources
PubMed1975

[Activity of the alkaline phosphatase in the serum and bones of zinc-deficient and zinc-replenished cows].

In a study with five lactating dairy cows fed a semisynthetic diet, the changes in the activity of the alkaline phosphatase in the serum, bones and milk were investigated in response to dietary depletion and repletion of zinc. During a six-week depletion period (6 mg Zn/kg dry matter) the alkaline phosphatase in the serum decreased to only 82% of its initial level which, however, was reduced already due to a low zinc intake before the start of the study. After 19 weeks of depletion the activity had decreased to 43% of its initial level. Additions of zinc during the repletion increased the activity very clearly and to much higher values than the ones at the start of the study. Thus this effect of repletion was as large as that for the zinc content in serum and milk. The serum alkaline phosphatase indicated a dependence on the performance and represents a sensitive indicator of the zinc status. The activity of the alkaline phosphatase in the bones (Tuber coxae) decreased to 68% of its initial level after six weeks of zinc depletion. The alkaline phosphatase in the milk was not influenced by the zinc supply.

Alkaline Phosphatase↗
PubMed1975

[Changes in hemoglobin content, erythrocyte count and hematocrit in nickel deficiency].

In a total of four different studies, two of them involving two generations, the essentiality of nickel could be shown by reduced growth in response to a diet with 15 ppb nickel. In 30-day-old self-reared rats, anemia was induced in the Ni-deficient animals despite a high iron supply of 50 mg iron per kg diet. In the F1 generation of the Ni-deficient animals, the erythrocyte count had fallen by 36%, the hematocrit by 37%, and the Hb content by 44%. In the F2 generation in which the animals were given 100 ppm iron, surpassing their requirement three times, the blood parameters of the deficient animals were reduced by 8-10%. At the age of 50 days of the F1 generation the erythrocyte count had fallen 23% compared to the values of the control group, the hematocrit 14%, and the Hb content (16%) from 12.7 to 10.7 g/100 ml blood. An influence on the protein content of the serum and on the catalase activity of the erythrocytes was not observed and only at times was there an influence on the urea content of serum.

Anemia, Hypochromic↗