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M Kirschner

Publications and source records attributed to M Kirschner.

74 records · Page 5Linked to original sources

Microtubule assembly nucleated by isolated centrosomes.

Microtubules are involved in the morphogenesis of most cells and are the structural basis of the mitotic spindle. We report here that purified centrosomes nucleate the assembly of microtubules with unusual dynamic properties. This may have important implications for the mechanism by which microtubule arrays are organized and stabilized in cells.

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Dynamic instability of microtubule growth.

We report here that microtubules in vitro coexist in growing and shrinking populations which interconvert rather infrequently. This dynamic instability is a general property of microtubules and may be fundamental in explaining cellular microtubule organization.

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