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Biomedical subjects

M Kitani

Publications and source records attributed to M Kitani.

50 records · Page 3Linked to original sources
PubMed1985

Long-term effect of cilostazol on cerebral blood flow in chronic cerebral infarction.

The effect of the oral administration of a new vasodilator, cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC-13013) on cerebral circulation in chronic cerebral infarction was studied by the 133Xenon inhalation method. Mean regional cerebral blood flow (rCBF) was increased in 6 out of 14 cases after 2 weeks of treatment. Hemispheric rCBF was significantly increased in both the affected and non-affected sides (10.8 and 13.4%, respectively) (p less than 0.05) without causing a change in blood pressure.

Aged↗
PubMed1984

Dysautoregulation of the cerebral circulation in primary systemic amyloidosis.

A case of primary systemic amyloidosis associated with marked dysautoregulation of the cerebral circulation in response to hypotension is reported. The major amyloid protein was immunoglobulin A lambda type. An autonomic nerve function test showed severe and extensive disturbances of the autonomic nervous system. The cerebrovascular reactivity to 5% CO2 inhalation was spared. To our knowledge, this is the first case to demonstrate that amyloid peripheral autonomic neuropathy can be accompanied by dysautoregulation of the cerebral circulation.

Amyloidosis↗
PubMed1984

Effects of naftidrofuryl on the time course of the regional cerebral blood flow in acute ischemic stroke.

The effects of naftidrofuryl (LS-121), which is known as an activator of the cerebral glucose metabolism in addition to acting as a cerebral vasodilator on the regional cerebral blood flow (rCBF), were investigated in acute and subacute ischemic stroke patients. Six acute patients and 5 subacute patients were treated with 100-200 mg/day of naftidrofuryl for 7-14 days, and the rCBF was measured before and after the treatment by the 133Xe inhalation method. The hemispheric rCBF was significantly increased by 24% for the acute stage and 22% for the subacute stage in the affected side, compared with the stage-matched control group. Naftidrofuryl may accelerate the recovery of the rCBF of the affected hemisphere even in the acute stage.

Adult↗