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Biomedical subjects

M Kitazawa

Publications and source records attributed to M Kitazawa.

At least 73 records · Page 4Linked to original sources
PubMed1989

[Continuous subcutaneous infusion of GnRH agonist: effective dosage in the treatment of endometriosis and its influence on the ovarian response to human menopausal gonadotropin].

This study was designed to compare the clinical and hormonal efficacy of the treatment for endometriosis using continuous infusion of three different doses of GnRH agonist (A). In addition, we examined the ovarian responsiveness to human menopausal gonadotropin (hMG) administration during GnRH-A treatment. Thirteen endometriosis patients were divided into 3 groups and given different doses. GnRH-A (Buserelin) was infused continuously through the subcutaneous route at rates of 200 micrograms (Group I; n = 5), 100 micrograms (Group II, n = 4) and 10 micrograms (Group III; n = 4) per day for 24 weeks. After the start of treatment, serum estradiol (E2) was suppressed to the menopausal range within 2 weeks and thereafter maintained this range until 24 weeks in each group. The LH and FSH response to a GnRH Challenge test was completely abolished within 2 weeks in 3 groups. Although serum FSH decreased to below the pretreatment value within a week, the FSH level was significantly lower in groups I and II than in group III until 8 weeks. No difference in the LH level during the treatment was seen among the 3 groups. After completion of the 24 weeks' treatment, FSH increased rapidly, and ovulation returned within 4 to 6 weeks in each group. Pregnancy was achieved in two patients in group I, one patient in group II and one patient in group III during cycles 2 and 5. Serum E2 increased to 200-300 pg/ml in 3 out of 7 patients treated with hMG during GnRH-A infusion, whereas no increase in E2 was seen in the remaining 4 patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1988

Pulsatile secretion of prolactin and luteinizing hormone and their synchronous relationship during the human menstrual cycle.

Recent investigations have demonstrated the pulsatile nature of prolactin (PRL) secretion and the synchronous relationship between PRL and LH pulses in normal and hypogonadal women. The present study was designed to confirm this synchrony and to investigate the characteristics of PRL pulses at different stages of the menstrual cycle. Blood samples were obtained at 10-minute intervals, beginning at 10.00 hours, for a duration of 4-7 hours, from women during the follicular (n = 11), preovulatory (n = 2) and luteal (n = 10) phases. Detectable pulses in plasma PRL concentrations were present in almost all subjects during each phase of the cycle. During the total 121-hour blood sampling throughout the 3 phases, 62 PRL pulses and 74 LH pulses were detected and about 80% of the PRL pulses were observed to coincide with LH pulses. The mean (+/- SD) pulse frequency of PRL was significantly lower during the luteal phase (0.28 +/- 0.17 pulses/hour) than during the follicular (0.64 +/- 0.25 pulses/hour) and preovulatory (0.72 +/- 0.16 pulses/hour) phases, while the mean pulse amplitude of PRL was significantly greater during the luteal phase (6.8 +/- 2.3 ng/ml) than during the follicular (3.6 +/- 1.2 ng/ml) and preovulatory (4.1 +/- 1.0 ng/ml) phases. These changes in pulse frequency and amplitude were also observed in LH pulses between the follicular and luteal phases, except at the LH surge, when LH pulse amplitude increased markedly, but that of PRL did not alter. Furthermore, a positive linear correlation between the pulse frequency of PRL and LH (r = 0.74, p less than 0.001) was found throughout the 3 phases of the cycle. These results demonstrate that a marked degree of synchrony between PRL and LH pulses is observed during the menstrual cycle and suggest that the frequency and amplitude of PRL pulses vary from the follicular to luteal phases, except at the LH surge, almost in parallel with those of LH pulses.

Adult↗
PubMed1988

[Pulsatile secretion of prolactin during the human menstrual cycle].

Recent investigations have demonstrated the pulsatile nature of prolactin (PRL) secretion and the synchronous relationship between PRL and LH pulses in normal and hypogonadal women. The present study was designed to confirm this synchrony and to investigate the characteristics of PRL pulses at different stages of the menstrual cycle. Blood samples were obtained at 10-min intervals beginning at 1000 h for a duration of 4-7 h in women during the follicular (n = 11), preovulatory LH surge (n = 2) and luteal phases (n = 10). Detectable pulses in plasma PRL concentrations were present in almost all subjects during the each phase of the cycle. During the total 121 h-blood sampling throughout the three phases, 62 PRL pulses and 74 LH pulses were detected and about 80% of these PRL pulses were observed to coincide with LH pulses. The mean (+/- SD) pulse frequency of PRL was significantly lower during the luteal phase (0.28 +/- 0.17 pulses/h) than during the follicular (0.64 +/- 0.25 pulses/h) and preovulatory phases (0.72 +/- 0.16 pulses/h). The mean pulse amplitude of PRL was significantly greater during the luteal phase (6.8 +/- 2.3 ng/ml) than during the follicular (3.6 +/- 1.2 ng/ml) and preovulatory phases (4.8 +/- 1.4 ng/ml). These changes in pulse frequency and amplitude were also observed in LH pulses between the follicular and luteal phases, except during the LH surge when LH pulse amplitude increased markedly, whereas that of PRL did not alter. Further, a positive linear correlation between the pulse frequency of PRL and LH (r = 0.74; p less than 0.001) was found throughout the three phases of the cycle.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

Malignant lymphoepithelial lesion.

A case of undifferentiated carcinoma arising from benign lymphoepithelial lesion (BLEL) of the parotid gland was studied by light and electron microscopy. Histopathologically, the carcinoma was composed of pleomorphic anaplastic cells showing an undifferentiated type among abundant lymphoid tissue forming germinal center. Among the prominent lymphoid tissue, epithelial hyperplasia, dysplasia, and squamous metaplasia of the duct epithelium were found. Dysplastic epithelium revealed a transition with carcinomatous component in some areas. On the electron microscopic observation, the tumor cells were poorly differentiated, possessing desmosomes and intracytoplasmic filaments. The patient is alive and well 2 months after resection of the tumor, but has a high titer of serum Epstein-Barr virus capsid antigen in IgG. Eighty five cases of the malignant lymphoepithelial lesion (MLEL) including the present case are summarized.

Aged↗
PubMed1987

Merkel cell tumor.

A Merkel cell tumor appeared on the left cheek of an 83-year-old female was reported. The tumor was located mainly in the dermis and infiltrated to the subcutaneous adipose tissue with an involvement of the blood vessels and lymphatics at the periphery. Electron-microscopically, few of the dense-cored granules and the single globular aggregates of intermediate filaments at the nuclear indentations were observed. Electron-microscopic uranaffin reaction proved positive reaction on the dense-cored granules. Half of the cytoplasmic border was smooth, while the rest had short projections. Desmosomes or junctional complexes were not detected among the tumor cells. Immunohistochemically, the cytoplasm of tumor cell showed positive reaction to both neuron-specific enolase (NSE) and keratin. The single globular positive spots of the latter were localized in accordance with the aggregates of intermediate filaments. These findings suggested a neurogenic origin with double differentiation, epithelial and neuroendocrine, of the Merkel cell tumor.

Adenocarcinoma↗
PubMed1986

Plasma-free eicosapentaenoic acid/arachidonic acid ratio: a possible new coronary risk factor.

Seventy-six effort angina patients who had typical angina on exertion documented by treadmill stress test with evidence of ischemic ST-segment depression and 78 healthy volunteers in urban Japan were investigated in this study. Plasma free fatty acids (FFA) in both groups were determined using high-performance liquid chromatography. The relationships between the total cholesterol, high-density lipoprotein (HDL), triglycerides in plasma, and the genesis of coronary heart disease were also examined. The ratio (0.08 +/- 0.08) of eicosapentaenoic acid (EPA)/arachidonic acid (AA) in plasma FFA was significantly lower in effort angina patients than that (0.15 +/- 0.12) in healthy volunteers. The lower ratio was due to significantly lower levels of EPA in the patients than in normals. In 42% of angina patients, the ratio is below 0.03. In all age subgroups except the age 30-39 subgroup, the ratio of EPA/AA was significantly lower in patients than in normals, when divided into four subgroups by using a 10-year age interval. Though the total cholesterol and triglycerides were not significantly different between the two groups, HDL was significantly lower and total cholesterol/HDL ratio was significantly higher in effort angina patients than in healthy volunteers. However, there was no correlation between EPA/AA ratio and HDL in individuals in either group. From these results, it could be concluded that lower EPA/AA ratio is a new coronary risk indicator other than HDL.

Adult↗
PubMed1986

[Endocrine evaluation of induction of ovulation with pulsatile and continuous administration of human menopausal gonadotropin (hMG) in anovulatory women].

To evaluate the endocrine profiles during induction of ovulation with pulsatile and continuous administration of hMG (Pergonal), 3 patients with polycystic ovarian disease (PCO) and 4 patients with hypothalamic amenorrhea were selected as the subjects. The total dose of hMG per day was 150 IU in each patient. hMG pulse was administered intravenously via a portable infusion pump every 90 min in 4 patients including 3 PCO cases (9.375 IU/pulse) and every 18 min in one patient (1.875 IU/pulse). The remaining 2 patients received continuous subcutaneous infusion of hMG (150 IU/day). Following hMG treatment, 8,000 to 10,000 IU of hCG was used to induce ovulation. All 7 patients ovulated and 4 of them conceived. Pregnancy resulted in 2 patients following pulsatile (every 90 min) administration and in 2 patients after continuous infusion. The duration of hMG treatment needed to induce ovulation was similar among the three modes of administration and within the range of 7 to 10 days. A sustained elevation of circulating FSH levels was observed in all patients and serum estradiol increased more than 3,000 pg/ml in 6 of 7 patients during the course of treatment. Mean (+/- SE) midluteal progesterone level was 107.1 +/- 20.9 ng/ml. Moderate to severe ovarian hyperstimulation occurred in all patients. These results indicate that both pulsatile and continuous administration of hMG are similarly effective in inducing ovulation. They also appear to indicate that the hMG-induced follicular development is profoundly affected by the maintenance of high levels of FSH in the circulation rather than by the mode of administering hMG, whether pulsatile or continuous.

Amenorrhea↗
PubMed1985

[Restoration of pituitary-ovarian function by pulsatile administration of GnRH during the early puerperium].

In general, the hypogonadotropic hypogonadism seen during early puerperium is thought to be due to long-term deprivation of endogenous GnRH during the course of pregnancy. Recently, based on the pulsatile nature of hypothalamic GnRH section, it has been demonstrated that pulsatile administration of this decapeptide is effective in activation of the pituitary-ovarian function and induction of ovulation in patients with endogenous GnRH deficiency. Thus, we investigated whether this physiological replacement of GnRH can bring about the rapid restoration of the pituitary-ovarian function in early puerperal women. Fourteen postpartum women who had undergone cesarean section for obstetric reasons at 37-41 weeks of gestation volunteered for this study. Six of them received 10 micrograms (one subject received 5 micrograms) of GnRH in every 90 min from day 0-5 postpartum for 7-17 days duration by a portable auto-infusion pump. The remaining 8 subjects without treatment served as controls. On day 14 postpartum, serum baseline values of LH and FSH were significantly higher and their responses to the 100 micrograms GnRH challenge test were significantly greater in GnRH-treated subjects than those in the control subjects, respectively. Serum estradiol levels increased day by day, reaching more than 500 pg/ml at the end of the treatment in the 6 subjects. One of them ovulated within 3 weeks postpartum following GnRH treatment and subsequent hCG administration. These results demonstrate that the physiological replacement of pulsatile GnRH can restore the pituitary-ovarian function even within the first 2 weeks postpartum and in the presence of puerperal hyperprolactinemia. They also suggest that a deficiency of endogenous GnRH secretion may account for, at least in part, the pathophysiology of the hypogonadotropic hypogonadism during early puerperium.

Chorionic Gonadotropin↗
PubMed1985

Giant cell tumor of the bladder associated with transitional cell carcinoma.

We report in detail the first giant cell tumor associated with transitional cell carcinoma of the bladder. The giant cell tumor was composed of multinucleated giant and mononuclear stromal cells, and was morphologically indistinguishable from giant cell tumor of the bone. The giant and transitional cell carcinomas showed no evidence of recurrence or metastasis 8 months after transurethral resection. No histogenetic correlation between the cancers was found.

Aged↗
PubMed1985

Crystalloid structure in adrenocortical adenoma.

The presence of crystalloid structures was demonstrated in the cytoplasm of a huge adrenocortical adenoma ultrastructurally. The crystalloids were classified into four types, and they differed from those of spironolactone bodies or intramitochondrial bodies in their size and shape. The structures of the crystalloids resembled the crystalloids of Reinke in the Leydig cells of the testis. Reports on intracytoplasmic crystalloids are rare in the tumors of the adrenal cortex.

Adenoma↗
PubMed1984

Malignant peritoneal mesothelioma with massive foamy cells. Codfish roe-like mesothelioma.

An autopsy case of a 45 years old Japanese female with malignant masothelioma showing peculiar stromal change was presented. The tumor had occupied the abdominal cavity around the uterus and both ovaries, and was diagnosed as a malignant peritoneal mesothelioma of epithelial type. The characteristic feature of the tumor was that the foam cells, which contained abundant amount of lipid droplets in the cytoplasm, and were thought to be histiocytes, massively occupied the stroma of the papillary tumor. Macroscopically, the tumor simulated a codfish roe. To our knowledge, no case of this sort of appearance of mesothelioma has ever been reported.

Adult↗