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Biomedical subjects

M Kittlick

Publications and source records attributed to M Kittlick.

At least 19 recordsLinked to original sources
PubMed1988

[Bacteriological findings in bronchial secretions of children with chronic, nontuberculous lung diseases and their relationship to local transferrin values].

In 142 bronchial secretions from 63 children with chronic nontuberculous lung diseases the content of transferrin was studied. In 68 samples (= 48%) transferrin has been found in concentrations between 0.1 and 13.9 mg/100 mg total protein. Fifty six of the secretions were analysed bacteriologically, microbes have been isolated in 37 of them (66%). Of the detected bacteria 5 species were considered as potentially pathogenic. The bacterial growth has been shown more frequently in secretions of patients with heavily inflamed bronchial mucosa. In bacterially contaminated secretions the occurrence of transferrin was reduced.

Bacteria↗
PubMed1987

[Microbiologic aspects of inflammatory joint diseases].

Regarding of microbiological aspects of arthritis three forms of joint diseases are under investigation: the septic arthritis, the reactive arthritis and the Rheumatoid Arthritis. In 95% of patients with septic arthritis microorganisms as causative agents responsible for the disease are described: Staphylococci, Streptococci, some gram-negative bacteria. By an haematogenic route of infection predominantly patients with immunosuppressive therapy are altered. In newborns and children septic arthritis is to observe more rarely. A reactive arthritis is a postinfectious sterile process in dependence on an infection occurred at an earlier time. As etiologic agents Yersinia, Enterobacteriaceae and Campylobacter have been discovered. 80% of the patients suffering such a reactive arthritis are carrier of the HLA-B27 system. The etiology of the Rheumatoid Arthritis is an open, unanswered problem. Of importance are: immunogenetic conditions, autoimmune phenomena, endocrinologic, dietetic and psychologic factors as well as bacteria and viruses as causative agents: cocci, bacilli, Diphteroids, endoparasitic bacteria (Listeria, L-forms, Mycoplasma, Chlamydiae), viruses (Adeno-, Mumps-, Measles-, ECHO-, Coxsackie-A- and B-, Hepatitis-, Cytomegalo-, Para-influenza-, Retro-, Parvo- and Rubella viruses). In the last years the EBV is of interest covering the question of a distinct virus persistence in tissues and the adequate limiting factors. Perhaps a defect of the hu-IFN-gamma-system might be of immunopathological and clinical significance.

Arthritis, Infectious↗
PubMed1987

[Immunoglobulin A and its significance for mucosa immunity--a contribution to the understanding of microbial interactions].

The secretory immunoglobulin A is still dominating with regard to knowledges and further investigations of the causes of mucosal immunity. Origin, formation, structure and mode of action of s-IgA are extensively explored. In the clinical range results of researches on symptoms and consequences of selective IgA deficiency are gaining importance, increasingly. Patients with IgA defect suffer up to 40 times more frequently from allergies and autoimmunopathies. In the induction of the immune response cellular components of mucosa immunity attaining the Lamina propria and the epithelium with the effector cells of Peyer's patches play a particular role.

Animals↗
PubMed1987

[Serum protein determinations in patients with chronic glomerulonephritis and their mathematical-statistical analysis in relation to suitability for renal immunogram].

Different immunological parameters (immunoglobulins, complement, lysozyme, and others) were tested in the sera of 65 patients with two forms of chronic glomerulonephritis (mesangiopathic and membranoproliferative GN). The results were compared with values received from 30 healthy human beings. All the data were analyzed carefully by different statistical methods to find out parameters available for a renal immunogram. Out of 14 parameters 4 were indispensable to the GN-groups: alpha 2-macroglobulin, beta-lipoprotein, alpha 1-acid-glycoprotein, lysozyme.

Acute-Phase Proteins↗
PubMed1980

[Aetiology and importance of viral diseases of the respiratory tract (author's transl)].

After discussion of the epidemiological situation of acute respiratory diseases and their economic consequences, and after a survey of clinical signs and symptoms, a review is given of the most important viral agents causing such diseases. That are influenza, parainfluenza, respiratory syncytial, adeno, corona, REO, and rhino viruses, which are prevalent in the respiratory tract. Viruses predominantly localized outside of the respiratory tract as well as bacteria and bacteria-like microorganisms are only shortly mentioned. Most weight is given to virological problems (morphology, antigenic structure), to pathogenic property and importance of viruses causing acute respiratory diseases.

Adenoviruses, Human↗
PubMed1980

[Virological diagnostics of acute respiratory diseases].

Considering mainly practical aspects, a review of available methods of virological diagnosis of acute respiratory diseases is given. The first part contains the elements of virological diagnostics, especially a description and valuation of rapid detection of virus using fluorescent antibodies, and of haemadsorption technique for rapid diagnosis. Moreover, methods of viral isolation (cell cultures, embryonated eggs), conventional serological tests (CFR, HAIT, NT), and recent, not yet generally applied serological techniques (passive haemagglutination, indirect fluorescent antibody technique, haemadsorption inhibition test, radial immunodiffusion, radial immunohaemolysis, radio immune assay, enzyme linked immune assay) are described and valued as diagnostic tools in viral diseases of respiratory system. The second part deals with the specific diagnostics of infections by influenza, parainfluenza, RS-, adeno-, corona-, and rhinoviruses. Special instructions for the application of available tests and for the interpretation of results are given.

Acute Disease↗
PubMed1979

[The clinical value of unspecific humoral immune parameters. Attempt at an immunogram. II. Quantitative determination of CH50E, CB50E, C3, C4 and lysozyme and measurement of indirect phagocytosis rate in the serum of patients with chronic pyelonephritis].

In 183 patients with chronic pyelonephritis as unspecific humoral immune parameters CH50E, CB50E, C3, C4 and lysozyme as well as the indirect phagocytosis against Staphylococcus aureus SG 511 and E. coli were tested. Clinically a differentiation according to 3 degrees of the renal function and 3 degrees of the activity of the disease was performed. The statistical analysis took into consideration mean and limit values. With the help of contingency tables tendency pictures were developed. C3, C4 and lysozyme proved as suitable for a humoral immunogramme in chronic pyelonephritis. C3 was increased in clear activity, C4 and lysozyme in restricted renal function and expressed activity. In view of the high biologic variation of humoral test parameters advantages and disadvantages of an immunogramme are discussed. But for patients with chronic pyelonephritis finally the estimations of IgM, IgG, IgD, C3, C4 and lysozyme are regarded as clinically useful. A feasable immunologic test set should be controlled, precised and completed.

Adult↗
PubMed1977

[Studies on calf salmonellosis. 3. Preclinical evaluation of a Smd. Salmonella dublin live vaccine].

Results of preclinical assay, preparation and conservation of a S.-dublin live vaccine based on streptomycin dependent mutants and for oral application are demonstrated and discussed in detail. The used oral vaccine is very good tolerated by calves and results in stable immunity after administration of a daily dose of 5 x 10(10) bis 1 x 10(11) living Smd.-mutants for 10 consecutive days. Complete immunity developes in calves within a period of two weeks after the last antigen administration and persists up to the age of 5 to 6 months. Conserving the vaccine at low temperatures (-15 degrees C) the number of living organism is far-reaching preserved in the first 5 months after preparation. After thawing the vaccine is to be used within a period of 3 days. With respect to the preparation of the live vaccine on semisynthetic nutritiv media some informations are given concerning the improvement of bacterial yield.

Administration, Oral↗
PubMed1976

[Studies with the macrophage migration inhibition test in patients with rheumatoid arthritis].

The authors intended to investigate whether lymphokinins can be verified in rheumatoid arthritis, and if so - to what extent. They used the macrophage-migrations-inhibition test (MMIT). The validity of the experimental model was therefore tested in patients with tuberculosis. In 97 examinations with 76 exactly defined R.A.-patients no significant migrationsinhibitions were present, apart from single findings. Various synovialis extracts and R.A.-synovia were used. The experimental conditions were varied up to a maximum factor of 8. The results obtained were discussed from the point of view of methodical accuracy, unsatisfactory preparation of antigens and possible double inhibition effects.

Arthritis, Rheumatoid↗
PubMed1975

[Immuno-prevention of coli infections in swine using live vaccine. 1. Use in coli infections during the 1st days of life].

Live vaccine prepared from streptomycin-dependent mutants of E. coli was well tolerated in various doses and at various times of administration, for there were no adverse reactions. There was no evidence of reversion to a virulent form. Efficacy was closely related to frequency of application of the vaccine. Vaccination must be performed as early as possible to immunize against infection during the first few days of life. It was possible to confer protection against the diarrhoea that occurs at 3-4 weeks of age. The use of an oral vaccine under intensive husbandry systems was shown to be safe. When the piglets were kept in cages, the vaccine could be administered in the existing mixing tanks for water supply, without the need for special equipment. Oral immunization of pigs already infected or already ill did not aggravate the existing infection, whether the animals were housed individually or in pens. Because of the dilution effect of the mixing tank and water supply pipes, the dose of vaccine, given on ten successive days, should be calculated at 10(9) organisms of the E. coli mutant per animal. This should supply a number close to the desired bacterial count of 10(10) organisms per animal daily. Immunization significantly reduced the frequency of gastrointestinal diseases during the first three weeks of age in piglets.

Animals↗