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Biomedical subjects

M Klee

Publications and source records attributed to M Klee.

27 records · Page 2Linked to original sources
PubMed1983

Intra-arterial perfusion therapy with 5-fluorouracil in patients with metastatic colorectal carcinoma and intractable pelvic pain.

In a phase-II trial, 18 patients with intractable pelvic and perineal pain caused by local recurrent and/or metastatic colorectal carcinoma resistant to combinations of analgesics, systemic cytostatic chemotherapy and/or radiation were treated with intra-arterial perfusion therapy using 15-30 mg 5-FU/kg body wt./day for 1-5 days. Of 18 patients, ten achieved complete pain relief for 3-32 weeks (mean, 15.7 weeks); after the perfusion therapy eight used less than 50% of the amount of analgesics required before treatment; one patient had only a minor response; two patients were treated unsuccessfully. Side effects were mild and controllable. One patient died subsequent to arterial embolism in the leg where the catheter was placed; pelvic perfusion therefore appears risky in patients with severe arteriosclerosis.

Adult↗
PubMed1981

[Plasmapheresis: First clinical results in malignant tumors].

32 patients (10 females and 22 males) with chemotherapy-resistant tumors were again treated with the previously ineffective chemotherapy after plasmapheresis. 19 of 32 patients showed a minor response or no change lasting more than 3 1/2 weeks; in 10 of the 32 patients it lasted for more than 8 weeks.

Colonic Neoplasms↗
PubMed1981

[Treatment of epidermoid head and neck cancer with cisplatinum/bleomycin vs methotrexate/vindesine].

Treatment of patients with advanced squamous head and neck tumors demonstrates even with best surgical and x-ray techniques only five year survival rats between 10 and 30%. Chemotherapy in addition seems to improve these results. From July 79 to January 80 21 patients with advanced squamous-cell carcinoma at the head and neck region were treated in a controlled pilot study with Cisplatinum/Bleomycin or Methotrexate/vindesine. 6 patients were primarily treated with chemotherapy, all other secondary progressive disease after surgical and x-ray procedure. Without respect to the generally cell tolerated therapy modality on overall remission induction rate of 50 and 70% was observed. In a subsequent randomized controlled multicentric study both regimes will be compared concerning remission, survival and toxicity.

Bleomycin↗
PubMed1973

Intracellular biopotentials during static extracellular stimulation.

Two properties of the intracellular potentials and electric fields resulting from static extracellular stimulation are obtained for arbitrarily shaped cells. First, the values of intracellular potential are shown to be bounded by the maximum and minimum values of extracellular potential on the surface of the cell. Second, the volume average of the magnitude of intracellular electric field is shown to have an upper bound given by the ratio of the magnitude of the largest extracellular potential difference on the surface of the cell to a generalized length constant lambda = [sigma(intra)V(cell)/(sigma(memb)A(cell))](1/2), where V(cell) and A(cell) are the volume and surface area of the cell, sigma(intra) is the intracellular conductivity (reciprocal ohms per centimeter), and sigma(memb) is the membrane conductivity (reciprocal ohms per square centimeter). The use of the upper bound on the volume average of the magnitude of intracellular electric field as an estimate for intracellular isopotentiality is discussed and the use of the generalized length constant for electrically describing arbitrary cells is illustrated for cylindrical- and spheroidal-shaped cells.

Cell Membrane↗
PubMed1972

Finite difference solution for biopotentials of axially symmetric cells.

The finite difference equations necessary for calculating the three-dimensional, time-varying biopotentials within and surrounding axially symmetric cells are presented. The method of sucessive overrelaxation is employed to solve these equations and is shown to be rapidly convergent and accurate for the exemplary problem of a spheroidal cell under uniform field stimulation.

Cell Membrane↗
PubMed1972

Integral equation solution for biopotentials of single cells.

A Fredholm integral equation of the second type is developed for the biopotentials of single cells. Two singularities arise in the numerical solution of this integral equation and methods for handling them are presented. The problem of a spherical cell in an applied uniform field is used to illustrate the technique.

Cell Physiological Phenomena↗