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Biomedical subjects

M Klinger

Publications and source records attributed to M Klinger.

At least 109 records · Page 6Linked to original sources
PubMed1990

Activity of type 1 erythrocyte complement receptors in uremia and after renal transplantation.

The effect of uremia on the activity of the erythrocyte complement receptors type 1 (CR1), and the changes occurring after renal transplantation, were studied. The complement receptor activity was measured by immune adherence utilizing a rosette technique. Patients with terminal kidney failure on the hemodialysis program exhibited significantly lower values of the erythrocyte CR1 activity in comparison with healthy controls. The circulating immune complexes did not affect erythrocyte CR1 activity. After successful renal transplantation, irrespective of the immunosuppressive program used, a significant increase in erythrocyte CR1 activity appeared, similar to control group values. However, the activity of erythrocyte CR1, in the graft recipients under cyclosporin A treatment, was significantly higher than in the patients receiving azathioprine with prednisone. Therefore, it is possible that cyclosporin A, transported in the erythrocytes, modifies the complement receptor function.

Adult↗
PubMed1989

Legionnaire's pneumonia complicating a thermal burn.

The report describes a patient with 45 per cent BSA burns who developed Legionnaire's disease 3 days after the acute injury. The diagnosis of this life-threatening complication was late because most of its signs and symptoms can be encountered in the burned patient. This delay could have been fatal to the patient and required the evacuation of the burn centre for disinfection.

Anti-Bacterial Agents↗
PubMed1989

[In vitro aging of erythrocytes].

Various in vitro-aging procedures are introduced as an alternative to the difficult isolation of physiologically aged erythrocytes standing immediately before elimination. N-acetylneuraminic acid, ATP- and glutathione contents of these model cells are estimated and the kind and degree of membrane damage were characterized by the rates of phagocytosis and exovesiculation. Conclusions concerning molecular biological mechanisms of age-related processes were drawn by correlating biochemical data with the degree of membrane lesion. Alterations of spectrin (cross-linking, aggregation, rearrangement) seem to play the main role in all in vitro-ageing processes described here.

Adenosine Triphosphate↗