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Biomedical subjects

M Kołaczkowska

Publications and source records attributed to M Kołaczkowska.

7 recordsLinked to original sources
PubMed1998

[The effect of chemotherapy on bone metabolism in patients with non-small cell lung cancer].

UNLABELLED: In this study the influence of chemotherapy on bone metabolism in patients with III stage of non-small cell lung cancer has been evaluated. 30 patients (men) in average age 57.1 years were enrolled to this trial. The trial carried out on 2 groups of patients: group A consisted of 30 patients with NSCLC, group B of 15 patients without neoplastic process. In all participants bone scintigraphy was done and the following biochemical markers were measured: osteocalcin concentration, alkaline phosphatase's bone fraction, twenty-four-hour calcium and hydroxyproline urine excretion. In patients after two courses of chemotherapy (mitomycin, cisplatin, vinblastine) statistically significant reduction of serum concentration of osteocalcin, alkaline phosphatase, also reduction of calcium and hydroxyproline urine excretion have been observed. Scintigraphic examination of bones showed statistically significant decrease in resorption of isotope (MDP 99mTc) in patients after chemotherapy (p < 0.05). CONCLUSIONS: The study shows positive influence of chemotherapy on bone metabolism in patients with NSCLC. Patients treated with chemotherapy have bone metastases less frequently.

Adult↗
PubMed1997

[Meigs syndrome--diagnostic difficulties].

Meigs' syndrome in 68 years woman with pleural effusion and ovarian tumour was described. The cause of the pleural liquid in Meigs' syndrome is still not clear. New views on the pathogenesis and diagnostic methods of pleural liquids causes were presented.

Aged↗
PubMed1996

[Long-term corticosteroid therapy as a risk factor of osteoporosis in patients with asthma and chronic bronchitis].

This work evaluates frequency of steroid induced osteoporosis according to kind of steroid drugs (systemic, inhaled), dose and duration of treatment. In group of 80 young patients with asthma and chronic bronchitis the following examinations have been used: biochemical markers of bone turnover, X-ray of thoracic lumbar part of vertebral column and bone density in quantitative computed tomography of vertebrae L2-L4. Osteoporosis appeared in patients chronically treated with systemic steroids (prednisone) and in patients treated with inhaled steroids in typical dose as well. Usefulness of biochemical markers of bone turnover in connection with quantitative computed tomography in diagnostic of steroid induced osteoporosis has been confirmed.

Adrenal Cortex Hormones↗
PubMed1983

Specificity of acid protease from Fusarium moniliforme.

Specificity of acid protease from Fusarium moniliforme was investigated using beta chain of oxidized insulin. The enzyme is highly specific for the bonds involving aromatic and hydrophobic amino acid residues. It shows high affinity for the following bonds: Leu(15)-Tyr(16), Tyr(16)-Leu(17), Phe(24)-Phe(25), Phe(25)-Tyr(26), and somewhat lower for other three bonds: His(10)-Leu(11), Leu(11)-Val(12) and Tyr(26)-Thr(27) in oxidized beta chain of insulin.

Amino Acid Sequence↗
PubMedDate not supplied

[Sudden death in the course of sarcoidosis of the heart].

A case of 46-years old patient with morphological diagnosis of hilar lymph nodes sarcoidosis is presented. Patient complained of mild degree of shortness of breath and easily fatigability. Chest X-ray examination showed enlargement of both hilar lymph nodes and slight increase in heart size. In electrocardiography (EKG)--left bundle branch block. It was diagnosed first degree sarcoidosis without involvement of lungs. It was beginning the steroid treatment because of suspicion of sarcoidosis of heart. Patient died suddenly in 17 day of treatment. Post mortem examination proved sarcoidosis of heart. In spite of cardiac involvement in sarcoidosis only a few patients have cardiac symptoms or signs.

Cardiomyopathies↗