PubMed Health⌕ Search

Biomedical subjects

M Kojiro

Publications and source records attributed to M Kojiro.

At least 163 records · Page 9Linked to original sources
PubMed1985

Thorium dioxide-related angiosarcoma of the liver. Pathomorphologic study of 29 autopsy cases.

We describe the pathomorphologic features of 29 autopsy cases of thorium dioxide-related angiosarcoma (AGS) of the liver. The average (+/- SD) latent period after thorium dioxide injection was 36.2 +/- 5.2 years. Macroscopically, thorium dioxide-related AGS was divided into four types as follows: diffuse micronodular, multinodular, massive, and mixed multinodular and massive. Diffuse-micronodular and multinodular types were the most common. Histologically, thorium dioxide-related hepatic AGS was characterized by two cell types (spindle-shaped cells and polyhedral cells) and two structural patterns (sinusoidal and solid). There was no case composed of a solid pattern only. Immunohistochemically, factor VIII-related antigen was found to be positive in the endothelial cells of normal blood vessels and in the hyperplastic endothelial cells of the sinusoids, but negative in the tumor cells. Extramedullary hematopoiesis was found in both the tumorous and nontumorous areas in four cases. Erythrophagocytosis by the tumor cells was found in three cases. In the nontumorous area, varying degrees of sinusoidal dilatation with frequent hyperplastic changes of the sinusoidal lining cells were observed in all cases. These sinusoidal changes were frequently contiguous to AGS foci and were considered as a precursor change. In addition to the dominant sinusoidal changes, nodular hepatocytic hyperplasia was observed in two cases.

Adult↗
PubMed1984

Hepatocellular carcinoma with intra-atrial tumor growth. A clinicopathologic study of 18 autopsy cases.

We studied the features of 18 cases of hepatocellular carcinoma (HCC) with prominent intra-atrial tumor growth that were seen among 439 autopsy cases of HCC. Diuretic-resistant, marked edema in the lower extremities and marked venous dilatation in the abdominal wall were observed in 14 cases (77.7%) and five cases (27.7%), respectively. Consistent tachycardia was seen in three cases. Macroscopically, most of the cases showed an infiltrative or mixed (infiltrative and nodular) growth pattern. A continuous tumor thrombus involving the right atrium, the IVC, and the hepatic vein was seen in 15 cases; a tumor that involved the right atrium alone was present in three cases. In five cases, the tumor bolus crossed the tricuspid valve and entered the ventricle.

Abdomen↗
PubMed1983

Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years.

The pathologic findings of 232 consecutive cases of hepatocellular carcinoma (HCC) autopsied during the past ten years at Kurume, Japan, were analyzed from the point of view of global epidemiology, in relation to clinical feature, and in regard to incidence, age, sex, etiologic factors, size of liver, changes in noncancer parenchyma, gross type of tumor, extrahepatic metastases, intravascular and intraductal growths, cancer cell histology, hepatitis B surface antigen (HBsAg) in hepatocytes and cancer cells, liver cell dysplasia, and frequency and clinicopathologic characteristics of minute HCC. Furthermore, postmortem hepatic arteriography and portography were done in 152 livers for comparison with gross anatomy and celiac angiograms. It was found that: (1) epidemiologically, HCC in Japan is distinct from that in the West that it is frequently encapsulated, livers are generally small because of frequent and advanced cirrhosis and small cancer, minute HCC, is not uncommon at autopsy, cirrhosis most commonly associated is the one with thin stroma and medium size nodules, and micronodular cirrhosis is very rare despite frequent alcohol abuse; (2) HCC is increasing in incidence; (3) HBsAg is frequently found in parenchyma; (4) liver cell dysplasia is indirectly related to HBsAg with no evidence for premalignancy; (5) the lung is the most frequent site of metastasis but peritoneal dissemination is unusual; (6) intraportal tumor growth is very common and the hepatic vein is less frequently affected; (7) growth in the major bile duct is frequently associated with intraportal growth and clinically presents as obstructive jaundice; and (8) tumor is supplied solely by arteries and celiac arteriograms are closely correlated with gross pathologic findings.

Adenoma, Bile Duct↗
PubMed1983

Association of dysgerminoma and gaucher's disease.

A 22-year-old woman presented with splenomegaly and pancytopenia of over two years' duration. A splenectomy was performed because of a suspicion of Gaucher's disease. At the time of operation a left ovarian tumor was found and was removed. A diagnosis of Gaucher's disease was made on the basis of massive infiltration of histiocytes with typical cytoplasmic striations in the spleen, liver, and bone marrow. The ovarian tumor was characterized by a monotonous, diffuse proliferation of large, rounded cells and was diagnosed as dysgerminoma. The association of Gaucher's disease and malignant tumors is rare, only several cases have been reported in the English literature. An additional feature of this case was the appearance of histiocytes showing the characteristic cytoplasmic striations of Gaucher's cells in the stroma of the tumor.

Adult↗
PubMed1983

Paratesticular rhabdomyosarcoma.

Two cases of paratesticular rhabdomyosarcoma were reported. One was a 53-year-old male, who was admitted to the Hospital because of swelling of the scrotum, hemosputa, and complete left hemiplegia. Clinical diagnosis was testicular tumor with remote metastases to lung, brain, liver, and para-aortic lymph nodes. At operation, tumor of 340 g of the paratesticular appendage was removed. Pathological findings of the tumor revealed rhabdomyosarcoma of mixed pleomorphic and embryonal types. The other was a 32-year-old male, who was admitted to the Hospital because of left inguinal and scrotal masses. The patient had a history of bruise at the left inguinal region about 5 years prior to admission. An orchiectomy and an excision of the inguinal tumor were performed. Histologically, the tumor was rhabdomyosarcoma of pleomorphic type. Clinical and pathological features of this rare tumor were discussed with a review of literature.

Adult↗
PubMed1983

[Pathology of hepatocellular carcinoma].

The discovery of alpha-fetoprotein and hepatitis B virus related antigens, and the development of diagnostic techniques in the past decade brought a new epoch in the study of hepatocellular carcinoma (HCC). Therefore, pathology of HCC should be re-investigated in accordance with the development of clinical aspects. In this paper, we have described the pathology of HCC based on both autopsy and surgical materials with special reference to angioarchitecture, unusual tumor growth, and histological growth pattern of HCC. Primary tumor, tumor thrombi in the portal vein and the hepatic vein, and intrahepatic metastasis receive arterial blood supply through arterial tumor vessels deriving from the hepatic artery. Unusual tumor growths, such as intrabile duct and intra-atrial tumor growths, have become relatively common, and tumor casts in the bile duct and the right atrium also receive arterial blood supply through arterial tumor vessels. histological growth pattern of HCC can be classified into three types; sinusoidal type, replacing type, and pseudoencapsulated type. The frequency of remote metastasis is different in each type.

Bile Duct Neoplasms↗
PubMed1982

Hepatocellular carcinoma presenting as intrabile duct tumor growth: a clinicopathologic study of 24 cases.

We describe the features of 24 cases of hepatocellular carcinoma (HCC) with prominent intrabile duct tumor growth seen among 238 autopsy and 21 surgical cases of HCC. Progressive obstructive jaundice occurred during the course of most cases and was the presenting sign in nine. A fluctuating rise and fall of the total bilirubin was seen in two cases. The average survival time of the cases was significantly shorter than that of HCC patients without intrabile duct tumor growth (Mann-Whitney's U-test, one-tailed, P less than 0.05). The average survival time after the development of severe jaundice (total bilirubin over 10 mg/dl) was only 16 days. Intrabile duct tumor casts were located in the hepatic and/or the common bile ducts in 19 cases (79%) and in five cases were seen in the peripheral (medium to small-sized) bile ducts. Hemobilia developed in five cases (21%) and was regarded as the immediate cause of death in one. Grossly all the cases presented infiltrative or mixed (infiltrative and nodular) growth pattern. Intrabile duct tumor growth and associated marked obstructive jaundice may frequently herald the terminal phase of HCC in certain patients. In our series, approximately 40% of patients with HCC and significant jaundice had gross evidence of extensive intraductal tumor growth. In the absence of intraductal tumor growth, jaundice in HCC usually was seen in a setting of progressive terminal hepatic failure.

Adult↗
PubMed1982

Thorotrast-induced hepatic angiosarcoma, and combined hepatocellular and cholangiocarcinoma in a single patient.

A 64-year-old man developed hepatic angiosarcoma, and combined hepatocellular and cholangiocarcinoma, 36 years after Thorotrast administration. The patient presented with a large mass in the right upper quadrant. His serum alpha-fetoprotein increased from 800 ng/ml to 51.2 micrograms/ml, and liver biopsy disclosed hepatocellular carcinoma. At autopsy, the liver had two different malignant neoplasms; angiosarcoma and combined hepatocellular and cholangiocarcinoma. Metastases of angiosarcoma to both lungs and of cholangiocarcinoma to periaortic lymph nodes were also seen. Interestingly, some neoplastic cells of angiosarcoma exhibited globular hyaline inclusions, which were Periodic-Acid-Schiff reaction positive and diastase-resistant.

Adenoma, Bile Duct↗
PubMed1982

Histologic growth pattern of hepatocellular carcinoma: relationship to orcein (hepatitis B surface antigen)-positive cells in cancer tissue.

The histologic pattern of tumor growth at tumor-nontumor boundaries was studied in 60 livers bearing hepatocellular carcinoma. Three growth patterns, arbitrarily described as "sinusoidal," "replacing," and "encapsulated," were distinguished. Cancer cells growing in the sinusoids between liver cell cords (sinusoidal pattern) were anaplastic; those growing in an expansile fashion and acquiring a fibrous capsule (encapsulated pattern) were most differentiated; and those growing into the cord of liver cells and replacing them (replacing pattern) were differentiated to an intermediate degree. There was certain relation between the histologic growth patterns and gross morphologic features of the tumors. Test results for 20 of the 60 cases were positive for serum hepatitis B surface antigen (HBsAg), and the livers also contained orcein-positive cells. Orcein-positive cells were frequently seen at the border between tumor and parenchyma. Cells containing HBsAg as an orcein-positive inclusion were present in cancer tissue in three cases. When serial sections were made from such areas and stained alternately with hematoxylin and eosin and orcein, it was found that these cells were hepatocytes blended with cancer cells. This phenomenon was related to the growth pattern of tumor cells. Orcein-positive cells were never found in metastatic lesions.

Adult↗
PubMed1982

[Distribution of 67Ga-citrate in 3'-methyl-4-dimethylaminoazobenzene-induced hepatoma of rats].

The distribution of 67Ga-citrate in the hepatoma of rat induced by 3'-methyl-4-dimethylaminoazobenzene was studied. 67Ga uptake ratio resected specimen, autoradiography and histological specimen were compared each other. 67Ga uptake ratio of the tumor was increased 1.6 to 7.2 times (average 4.4) to control group. Regardless of the size of the tumor, macroautoradiographically observed distribution of 67Ga-citrate in the hepatoma was higher in the peripheral zone than in the central zone. Histologically the degeneration of tumor cell was low or absent in the peripheral zone of tumor, whereas it was intense in the central zone. 67Ga-citrate was highly accumulated in the zone which the degeneration was low or absent. We, however, could not demonstrate the site where 67Ga-citrate was incorporated.

Animals↗
PubMed1981

A clinical and pathological study of diffuse type hepatocellular carcinoma.

Six autopsy cases of the rare, diffuse type of hepatocellular carcinoma (HCC), as classified gross anatomically according to the strict definition, have been studied. The prominent clinical feature was the rapid deterioration of the patient's general condition, terminating in hepatic failure. The liver size enlarged quickly, at a perceptible speed, often accompanied by abdominal pain. Diagnosis of this particular type of HCC was difficult, and celiac angiography and scintiscan of the liver were only suggestive when considered together with other laboratory data. Hepatitis B surface antigen was positive in all three patients in whom it was tested. The entire liver was studded with minute, uniformly sized tumor nodules, evenly distributed throughout. Some of them were grossly indistinguishable from cirrhotic nodules. All livers had an underlying cirrhosis which was characterized by relatively small regenerative nodules with thin stromas. Large portal branches at the hilum contained tumor thrombi in all patients, except for one case in which left lobectomy was followed by intraportal dissemination. Histologically, all tumor nodules represented intrahepatic metastases via the portal vein system. Tumor cells were poorly differentiated. These findings suggest that the diffuse type of HCC most frequently, if not always, represents intrahepatic, widespread portal metastases which have occurred within a short period of time.

Adult↗