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Biomedical subjects

M Kolopp

Publications and source records attributed to M Kolopp.

23 records · Page 2Linked to original sources
PubMed1983

Comparison of 5 reflectance meters for capillary blood glucose determination.

Manufacturing quality, accuracy and users opinion (i.e. medical and nurses staff and patients) were compared among five Destrostix reading reflectance-meters for home-blood-glucose-monitoring. Two machines (dextrometer and glucometer) equipped with microprocessors, integrated circuits and good quality wiring are best made. Reflectance-meter capillary blood glucose measurements were found to be accurate enough for home-blood-glucose-monitoring, compared to a reference method. However, two machines from the same brand were different in blood glucose accuracy. Glucocheck had poorest results. Users prefer small sized, battery powered machines. Glucometer appears to be best suited to home-blood-glucose-monitoring.

Blood Glucose↗
PubMed1982

[Influence of metabolic control on blood viscosity and platelet activity in insulin requiring diabetics].

Blood and plasma viscosities were determined using respectively a Couette type micro-viscometer (LS 30) and an automatic capillary viscometer (FICA). Plasma beta-thromboglobulin (beta-TG) levels were determined by radioimmunoassay. These parameters were measured in a group of 11 poorly controlled insulin requiring diabetics before and after blood glucose normalization using an artificial pancreas (Biostator GCIIS). Before connection to the artificial pancreas, blood and plasma viscosity and beta-TG levels were significantly higher in diabetics than in controls. The strict metabolic control obtained by the artificial pancreas resulted in a normalization of the hemorheological parameters and in a significant reduction of plasma beta-TG levels after 48 h. These results suggest that the metabolic control of diabetes influences the rheological behavior of blood and the metabolism of platelets.

Adolescent↗
PubMedDate not supplied

[Psychological aspects of remission induced by intensive insulin therapy in type I diabetes. A retrospective study of 44 patients].

The psychological consequences of induced remission of type 1 diabetes, have not yet been investigated thoroughly. We studied the psychological status of 44 patients (16 women, 28 men), age 21 years +/- 8 months (mean +/- SD), whose remission lasted 12 +/- 9 months. Patients' psychological reactions were analyzed retrospectively, using a 20 items standardized questionnaire, investigating 3 successive periods: 1) initial intensive insulin therapy; 2) remission; 3) permanent insulin therapy. 8% of the subjects only considered the remission phase useless, whereas 49% expressed a positive appraisal. Hope was predominant feeling, 25% of the patients believing in a completed recovery of diabetes. Perceived therapeutic constraints were, in decreasing order: regimen, way of life's regularity, self monitoring of blood glucose. When starting permanent insulin therapy, opposite answers were given: 49% negative feelings, 33% positive feelings and 18% ambivalent feelings. During this period, insulin injections represented the major therapeutic constraint, followed by self monitoring of blood glucose. To summarize, induced remission does not appear to be psychologically harmful and is considered useful by a large majority of patients. Effective psychological support has to be offered to help those patients to cope with their irrational hopes of healing and to dampen their deception at the end of the remission period.

Adult↗
PubMedDate not supplied

Overview of quantitative methods in toxicologic pathology.

Today's stringent requirements for new drugs make it necessary to prove their safety by the use of ever more refined techniques, in particular methods to quantify morphologic findings to determine accurately, for example, the highest non-toxic dose in animal studies or to correlate morphological effects with other parameters. Increased cell proliferation due to subtle cytotoxicity can lead to epigenetic tumorigenicity, which can be recognized early by cytokinetic investigations using bromodeoxyuridine (BrdU) incorporation and/or proliferating cell nuclear antigen (PCNA) expression, or by malignancy-associated nuclear texture changes. Morphometric criteria are also used to increase diagnostic accuracy in experimental animal pathology. The various applications of morphometry in toxicopathology are reviewed, and examples illustrating these applications are presented, most of them unpublished.

Animals↗