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Biomedical subjects

M Komatsuda

Publications and source records attributed to M Komatsuda.

At least 37 records · Page 2Linked to original sources
PubMed1986

Nodular sclerosing Hodgkin's disease with massive skin invasion.

Skin invasion is a rare manifestation in cases with Hodgkin's disease and if present mortality rate is very high. In general, almost all patients with advanced skin lesions die of the underlying disease in spite of any chemotherapy, however in case the patient recovered after intensive chemotherapy and irradiation. Moreover, the type of skin manifestation in this case is unique and quite different from the usual. This report describes a well-controlled case of Hodgkin's disease with massive and atypical skin invasion.

Adult↗
PubMed1984

A study of correlation between histological, staging classification and prognosis of malignant lymphoma.

In order to study the relationship between histological staging classification and prognosis, 62 cases of malignant lymphoma were analyzed retrospectively according to each histological type and staging classification during the last eight years (1976-1983). The findings obtained from this study were as follows: The incidence of malignant lymphoma in this department (Fourth Department of Internal Medicine, Tokai University) almost coincided with that reported before. Patients with Hodgkin's disease had almost the same results as that reported before even in the advanced stage. The prognosis of patients with non-Hodgkin's lymphoma was almost the same as that previously reported.

Adolescent↗
PubMed1983

Clinical evaluation of combination of cefmetazole and piperacillin in the treatment of infections in patients with acute leukemia.

27 episodes of infection in patients with acute leukemia were treated with combination of cefmetazole and piperacillin. Causative bacteria were isolated in each infection. The patients were treated with 6 g cefmetazole and 15 g piperacillin per day in three divided doses. Among the episodes of infection, 21 (78%) of 27 responded to cefmetazole and piperacillin. Adverse reactions were skin rash in 2 patients, transient elevation of serum glutamic-pyruvic transaminase in 3 patients and elevation of creatinine in 1 patient. Cefmetazole and piperacillin appear to be an effective combination, with acceptable adverse reactions, for the empiric therapy of infection in patients with acute leukemia.

Acute Disease↗
PubMed1983

Serial in vitro bone marrow fibroblast culture in human leukemia.

Human fibroblast colony formation from bone marrow was performed in liquid culture. Fetal calf serum was used as a stimulator of the fibroblast colony formation. The colony formation took place not only in normal donors, but also in patients with acute leukemia and chronic myelocytic leukemia. At the diagnosis of the disease, significant colony suppression was observed in most cases of acute leukemia, while the number of colonies increased in half of the cases of chronic myelocytic leukemia. However, there was no correlation between the colony-forming efficiency and the initial number of peripheral platelets or bone marrow megakaryocytes that contained growth-promoting factor. The number of colonies increased after chemotherapy, recovered at the stage of complete remission, and then decreased to low levels at relapse in the patients with acute leukemia; it decreased after treatment with busulfan in the patients with chronic myelocytic leukemia. This fibroblast culture method is useful for counting fibroblast colony-forming cells in the bone marrow of human leukemia.

Acute Disease↗
PubMed1983

Inhibition of human bone marrow fibroblast colony formation by leukemic cells.

The number of bone marrow fibroblast colony formations decreases in most cases of acute leukemia before the initiation of chemotherapy. This study was undertaken to clarify the mechanism of suppression of fibroblast colony formation in leukemic patients. Titration of the number of bone marrow cells did not indicate a linear relationship between the number of bone marrow cells cultured and the number of fibroblast colony formations. The number of fibroblast colony formations recovered by removal of nonadherent leukemic cells following one day of incubation increased. The cloning efficiency of patient bone marrow still showed increases in colony formation at higher plating concentrations after the nonadherent cells were removed. When leukemic and normal bone marrow cells were cocultured, the suppressive effect of leukemic cells on normal marrow fibroblast colony formation was clearly observed. The suppressive effect disappeared at complete remission, and then reappeared at relapse. Heat-inactivated serum and bone marrow culture media from leukemic patients whose fibroblast colony formations were small in number suppressed fibroblast colony formation from normal bone marrow. From these results, it was concluded that the suppression of fibroblast colony formation in leukemic patients was through humoral factors produced by leukemic cells.

Acute Disease↗
PubMed1981

Fibroblast colonies in monolayer cultures of human bone marrow.

In a liquid culture of human bone marrow, the development of fibroblast colonies takes place on days 6 to 9. Twenty percent fetal calf serum is used as the stimulus fibroblast colony growth. Human bone marrow cells are plated as 2 x 10(5) cells in the culture. Normal human bone marrow yields 47 +/- 4 fibroblasts colonies per 2 x 10(5) cells plated. Bone marrow fibroblast cultures using agar or methylcellulose restrict colony formation. Marked colony suppression was observed in acute leukemia, and a discrete colony number was observed in hypoplastic anemia. This fibroblast culture method should be applied to a larger number of patients to determine whether it has a pathognomonic value and clinical significance.

Acute Disease↗
PubMed1981

Evaluation of cefmetazole and piperacillin with or without tobramycin for infections in patients with hematological disorders.

The combination of cefmetazole and piperacillin was compared with the combination of cefmetazole, piperacillin and tobramycin in the treatment of 20 patients with hematological disorders. The response rate was similar for both treatments (90% vs. 80%), and the difference was not statistically significant. The rate of serum glutamic pyruvic transaminase elevation was higher in patients treated with cefmetazole, piperacillin and tobramycin than in those treated with cefmetazole and piperacillin. Cefmetazole and piperacillin without tobramycin appear to be an effective combination with acceptable toxicity for empirical therapy of febrile episodes occurring in patients with hematological disorders.

Adolescent↗
PubMed1981

Comparison of protected isolation techniques between the laminar airflow room and the life island unit.

The use of laminar airflow rooms and a life island unit for comprised patients was evaluated. Six patients spent a total of 170 days in the laminar airflow rooms and 112 days in the life island unit, and none acquired any exogenous infection. Patients were febrile for 7 out of 170 days (4.1%) in the laminar airflow rooms and 4 out of 112 days (3.6%) in the life island unit. No significant difference in the rate of deposition of organisms on settling plates and surface samples was found between the laminar airflow rooms and the life island unit. The advantages of the laminar airflow rooms are freedom of movement for patients and hospital personnel and patient comfort, while those of the life island unit are much lower purchasing and operating costs and portability.

Adult↗
PubMed1981

Chemoimmunotherapy with Krestin in acute leukemia.

The purpose of this study was to determine if immunotherapy with Krestin can prolong the durations of complete remission and survival. The patients were placed at random in the chemotherapy and chemoimmunotherapy groups. The median durations of complete remission and survival were longer in the chemoimmunotherapy group than in the chemotherapy group. The complete remission rate of the second induction was higher in the chemoimmunotherapy group than in the chemotherapy group. The cell-mediated immunity was somewhat enhanced in the chemoimmunotherapy group, while it was not enhanced in the chemotherapy group. These results suggested that Krestin administration for maintenance therapy was useful for prolongation of the durations of remission and survival time in patients with acute leukemia.

Acute Disease↗
PubMed1980

Septicemia during compromised host treated in a protected isolation unit.

Bacteriological, hematological and immunological data were evaluated in patients with septicemia in a protected isolation unit. Patients were randomly given antimicrobial prophylaxis. Three out of four episodes of septicemia occurred 2 to 4 days after discontinuing oral nonabsorbed antibiotics at the stage of leukopenia and immunodeficiency induced by chemotherapy. Death occurred within 10 days in two patients whose peripheral white blood counts did not recover. In the other patients sepricemia was suppressed and complete remission was achieved in one of them. Parentheral administration of antibiotics is necessary after discontinuing oral prophylactic antibiotics in a protected isolation unit.

Acute Disease↗
PubMed1980

The effect of bestatin on patients with acute and chronic leukemia and malignant lymphoma.

The effects of bestatin was studied in 17 patients with acute and chronic leukemia, and three patients with malignant lymphoma with or without concomitant chemotherapy. Complete remission was obtained in eight patients with acute leukemia and in three patients with malignant lymphoma. Definite effects on both clinical and hematological findings have not been observed in patients with chronic myelogenous leukemia. The PPD and PHA skin reactions increased in about 60 percent of the patients examined. Effects of bestatin on hematological and immunological parameters were obtained at a daily dose of from 30 to 90 mg of bestatin everyday for more than 2 weeks. Bestatin appeared to be useful for the maintenance therapy of hematological malignancies. No side effects due to bestatin were detected.

Adolescent↗
PubMed1980

Human bone marrow contains fibroblast colony forming cells.

In a liquid culture of human bone marrow, the development of fibroblast colonies begins to take place on day 4. Twenty per cent fetal calf serum is used as the stimulus for fibroblast colony growth. Human bone marrow contains 47 +/- 4 fibroblasts colonies per 2 X 10(5) nucleated cells plated. Bone marrow fibroblast cultures using agar or methylcellulose restrict colony formation. This fibroblast culture method may be useful for pathognomonic and clinical studies in hematological disorders.

Adult↗