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Biomedical subjects

M Konecný

Publications and source records attributed to M Konecný.

At least 37 records · Page 2Linked to original sources
PubMed1982

Carcinoma cervicis uteri. Long-term follow-up therapeutic results.

The principle of the therapy of carcinoma cervicis uteri in the Research Institute of Clinical and Experimental Oncology in Brno is the combination of betatron megavoltage irradiation and cobalt 60 irradiation with intracavital radium irradiation. On the basis of many years' study concerning the therapy and therapeutic results of this tumor accurate directions of total therapy were elaborated. Carcinoma is diagnosed and classified precisely according to valid international directions. In addition to basic examination, limb lymphography was introduced giving the strategy of irradiation when lymphatic system is involved and in early stages of the disease. By preliminary evaluation of the obtained data a certain improvement of therapeutic results is proven. About 15% more patients are alive till 5 years without any signs of the disease than in precedent years. In spite of a high dose summation given by the extent of megavoltage irradiation the number of postirradiation reaction, nor early late, is increased to much. Complex therapy of this tumor is performed by a team of physicians composed of gynecologist, radiologist, rentgendiagnosticist, pathologist, and radiation physicist. By increasing the number of cured patients and their return and enclosure into further working process the savings in state budget are achieved. The effectiveness of the carcinoma cervicis uteri therapy is therefore dependent not only on earlier diagnosis and modern irradiation technique, but also on the cooperation of a team of physicians who plan, perform and follow the therapy.

Carcinoma↗
PubMed1981

Study of radiation dose fractionation in some tumor types.

In the presented work we have tested another fractionation schemes than simple fractionation in some so-called radioresistant tumors, i. e. in breast cancer and malignant melanoma. We have found the advantage of the irradiation with divided series (split irradiation) namely in malignant skin melanoma where we gained therapeutic results with 58% 5-year survival. Periodical irradiation especially with higher fractions once a week had encouraging success in advanced stages of the breast cancer where a single fraction of 8 Gy/tumor up to total dose of 40 Gy/tumor was determined as optimal. With the use of higher fractions more pronounced late postirradiation changes are to be expected. Fraction schemes were compared using NSD and TDF equations.

Aged↗