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Biomedical subjects

M Konn

Publications and source records attributed to M Konn.

At least 19 recordsLinked to original sources
PubMed1992

[An experimental study on development of gallstone disease after curative gastrectomy for cancer--postoperative alteration of the composition of canine gallbladder bile after subtotal gastrectomy with truncal vagotomy].

In connection with gallstone (GS) formation after gastrectomy for cancer, we examined alteration of the composition of gallbladder bile after subtotal gastrectomy with truncal vagotomy. Of 11 mongrel dogs with cholecystostomy, 3 underwent B-I and 4 B-II gastrectomy. Four dogs without gastrectomy were served as controls. Bile was collected for 12 months. Bile acids were quantified by GLC. The bile was cultured for bacteriology. TBA did not significantly differ among the three groups of the dogs. In the two gastrectomized groups, CDA (a secondary bile acid) kept a higher level and CA (a primary bile acid) maintained a lower concentration compared with those in the controls. A remarkable increase of non-conjugated bile acids was recognized in both gastrectomized groups. Lithogenicity was low for all of the 3 groups. All but 1 control dog incurred bile infection that persisted long. Black pigment stones containing calcium bilirubinate developed in 1 of the 3 B-I and 2 of the 4 B-II dogs but none in the controls. The bile infection seemed to be involved in the development of GS. As the alteration of bile composition and GS occurred solely in the gastrectomized dogs, subtotal gastrectomy with truncal vagotomy might precipitate the GS formation.

Animals↗
PubMed1991

[Continuous hyperthermic peritoneal perfusion (CHPP) therapy in advanced gastric cancer].

In CHPP therapy for advanced gastric cancer, a perfusate containing 20 mg CDDP and 8 mg MMC in 1,000 ml physiologic saline warmed at 47 degrees C was infused at a constant rate of 200 ml/min into the pouch of Douglas. The intraperitoneal temperature at the supra-pancreatic region was around 39.0 degrees C. To obtain a more stable and higher intraperitoneal temperature, the infusing rate was increased to 400 ml/min. This yielded a 3 degrees C higher temperature (42 degrees C) at the same measuring site. However, the temperature recorded at various intraperitoneal sites did not always reach such an effective range. The maximal plasma concentrations of MMC determined during CHPP at the 200 and 400 ml/min infusion were 0.09 +/- 0.03 and 0.11 +/- 0.03 microgram/ml, and those of CDDP 1.6 +/- 0.4 and 1.7 +/- 0.3 microgram/ml, respectively, all of which were not significantly different. When an intraperitoneal dosage of 20 mg MMC was given to 3 patients, the portal venous blood, at 10 min after the administration, produced a 1.7 times higher concentration of the agent than did the peripheral venous blood. This discrepancy between the two concentrations was much smaller than found by other investigators in animal experiments.

Adult↗
PubMed1989

[Five cases of rectal cancer showing remarkable response to suppository administration of tegafur].

Five cases of rectal cancer, one male and 4 females, were preoperatively treated with Tegafur suppositories at 1,500 mg per day, for 8 to 21 days (mean, 14 days). These tumors were 2 early cancers and 3 advanced cancers, the configuration of which were one IIa type, one IIa + IIc type and 3 Borrmann 2 types. Their size ranged from 1.3 to 4.2 cm in diameter. Curative resections were performed in all cases, and the examination of the resected specimen revealed marked effects of Tegafur as follows: 1) Reduction of tumor size, 2) disappearance of cancer wall, 3) degeneration of cancer cells and destruction of cancer glands accompanied by fibrous stroma with infiltration of lymphocytes and plasma cells, 4) formation of xanthogranulomatous tissue with foamy histiocytes, which were characteristic findings showing that cancer tissue had been present there. As a result, rectal cancer clearly showed remarkable response to suppository administration of Tegafur for only about two weeks, if the tumor cells were sensitive to the drug.

Adult↗
PubMed1989

[Continuous arterial infusion therapy of recombinant interleukin-2 and cyclophosphamide in hepatoma and liver metastasis].

The continuous arterial infusion of only recombinant interleukin-2 (rIL-2) was used in 9 patients with unresectable liver metastasis of colorectal or biliary cancer. This therapy was undertaken for the activation of tumor infiltrating lymphocytes (TIL), but was not effective. Then we tried continuous arterial infusion of rIL-2 and low-dose cyclophosphamide (CY) for liver metastasis. 3 of the patients who received rIL-2 and CY showed partial remission of disease. This therapy was possibly effective because of the activation of TIL and the suppression of tumor infiltrating suppressor lymphocytes.

Adult↗
PubMed1989

[Role of bile glycoprotein in intrahepatic calculus formation].

To clarify the etiology of intrahepatic calculus formation, we examined the components of hepatic bile, particularly glycoprotein, in 20 controls and 10 patients with intrahepatic calculi. The results obtained were summarized as follows: 1) The yield of delipidized bile powder was approximately 2.5 times higher in intrahepatic calculosis than in control. Quantitative analysis revealed that protein and neutral sugar were significantly increased in intrahepatic calculosis as compared with those in control. In SDS-PAGE of the powder, both intrahepatic calculosis and control groups demonstrated almost similar patterns except for difference in stainability between groups. This indicates that glycoprotein, that had been already present in control bile, was markedly increased in hepatic bile in intrahepatic calculosis. SDS-PAGE also demonstrated a thick and deep-stained band near the starting point only in intrahepatic calculosis. 2) Chromatography obtained from gel filtration on Sepharose CL-6B revealed 2 large peaks, one in void volume (macromolecular) and the other in total volume (micromolecular) region. In chemical analysis, macromolecular fraction in intrahepatic calculosis was rich in galactosamine, fucose and sialic acid, and characterized by prominent serine and threonine, which indicated that it was composed mainly of mucin type sialoglycoprotein. The micromolecular fraction in both groups were rich in aspartic acid and mannose, which indicated that they were composed mainly of serum type glycoprotein.

Adult↗
PubMed1987

Regurgitant bile acids and mucosal injury of the gastric remnant after partial gastrectomy.

Three groups, each consisting of seven patients who had undergone either Billroth I, Billroth II, or pylorus-preserving gastrectomies, were evaluated more than 18 months postoperatively in terms of concentration and amount of bile acids in the gastric aspirate and histologic changes in the gastric remnant mucosa. Concentrations of bile acids were determined by gas chromatography and mucosal specimens were obtained by endoscopic biopsy. The total bile acid concentration and all of the individual fractional bile acid levels, whether free or conjugated, were significantly higher in the Billroth II group than in the other two groups. The amount of gastric aspirate was also highest in the Billroth II group. Endoscopic biopsy revealed glandular dysplasia to be predominantly in the Billroth II group. The presence of bile acids in the gastric remnant may contribute to mucosal injury, possibly leading to cancer in the gastric remnant, especially after the Billroth II operation.

Adult↗
PubMed1987

Interferon producing activity of lymph-node and peripheral blood lymphocytes in cancer patients.

The IFN producing activity of RLNL and PBL was studied in cancer patients using K562, PHA-P and OK-432 as inducers. In response to K562, IFN production was significantly greater in the PBL than in the RLNL, and the titer was about equal in the PBL and RLNL when OK-432 was used as an inducer. On the contrary, the amount of IFN produced by PHA-P was significantly higher in the RLNL than in the PBL. There was no definite relationship recognized between tumor progression and IFN productivity in the cases studied.

Adult↗
PubMed1986

[Two cases of intussusception of appendiceal mucocele: diagnostic value of preoperative ultrasonography].

Mucocele of the appendix was first described and named "Hydrops processus vermiformis" by Rokitansky in 1866. Intussusception of a appendiceal mucocele is very rare and we have been able to find only 14 previously reported cases. We present two cases with preoperative ultrasonography which is valuable for its diagnosis. Case 1: A 5-year-old male was admitted to Kahoku Hospital because of right lateral colic abdominal pain and tumor. Ba-enema examination revealed intussusception to the colon and ultrasonography showed the cystic mass of the appendix. Case 2: A 51-year-old female was admitted because of right lower abdominal pain. Ultrasonography was helpful showing the cystic tumor at the base of the appendix. Recent reports say that ultrasonography is valuable examination for its diagnosis. Also in our two cases preoperative ultrasonography was performed and gave us valid information for its qualitative diagnosis.

Appendix↗
PubMed1985

Cronkhite-Canada syndrome associated with a rectal cancer and adenomatous changes in colonic polyps.

A 52-year-old man with the clinical features of Cronkhite-Canada syndrome developed rectal cancer. Radiologic and endoscopic examinations revealed gastrointestinal polyposis. Histologic examination of the biopsied polyps showed cystic dilatation of glands with an inflammatory stroma. A later biopsy from a rectal polyp proved to be an adenocarcinoma. The totally resected colon and upper rectum had an ulcerated rectal cancer and numerous polyps; most of the polyps showed histological changes typical of the syndrome. Only three polyps had adenomatous changes at their surfaces. Adenomatous and carcinomatous changes of epithelia can occur in non-neoplastic polyposis of Cronkhite-Canada syndrome from which presumably a carcinoma can develop, as in the present case.

Adenocarcinoma↗
PubMed1985

Serum proteins among Dusads of Bihar.

Horizontal starch gel electrophoresis has been employed for the detection of haptoglobin, transferrin and albumin phenotypes among 88 Dusads of Bihar. No variant of the haptoglobins or transferrins has been found in this sample, whereas one individual showed bisalbuminemia.

Blood Proteins↗
PubMed1985

[Timing of surgical intervention in ulcerative colitis].

Ulcerative colitis is a borderline disease between medicine and surgery and ultimate evaluation of medical or surgical therapy remains to be settled. Except for the absolute indication for operation (toxic dilatation, perforation, bleeding and etc.), it is not always easy to consider surgery for this disease because so many factors influence its clinical course. Nevertheless, a prudent decision regarding surgery seems mandatory for a reasonable surgical therapy with a low mortality and high curability that enables an earlier rehabilitation and more complete social activity. The total number of primary operative cases of ulcerative colitis in our clinic over a period of March 1954 through the end of December 1983 was 30. A comparison of our experience up to the end of 1965 and since then has shown an operative mortality of 2/14 in the first and 1/16 in the second period, and that all these 3 deaths were through an emergency operation but not through 29 cases of elective surgery. It is emphasized that one of the most important factors influencing outcome of operation is whether or not it is undertaken as an urgent surgery during a hard time of the disease that has failed to respond to intensive medical treatment.

Adult↗
PubMed1977

Immunological and biochemical investigations on the fluorocarbon-treated antigens obtained from placenta and from cancer tissues.

Biochemical and immunological investigations were made on the nature of fluorocarbon-treated antigens obtained from placenta and cancer tissues. 1) By the diffusion in gel method, a specific antigen common to cancer tissues was found in placental tissue, but not in normal tissue. Immunoelectrophoretically, a characteristic precipitate line was found in alpha2-globulin region. 2) Further purification of the placental antigens was carried out by DEAE-cellulose chromatography. Four fractions positive to Folin reaction were detected. 3) Immunoelectrophoresis revealed that the active component was concentrated in a fraction eluted with 0.1 M NaCl in 0.05 M phosphate buffer, pH 5.8 (5.8-fraction). 4) Further purification of the active component was performed by using polyacrylamide gel electrophoresis. Chemical analysis indicated that it belonged to glycoprotein. 5) This substance did not induce anemia in rabbits and had no influence on the osmotic fragility of erythrocytes. These results indicate that this substance is different from the anemia-inducing substance which was previously reported by us.

Antigens, Neoplasm↗