Biomedical subjects

M Kopljar

Publications and source records attributed to M Kopljar.

4 recordsLinked to original sources

PubMed2002

Persistent cervical intersegmental artery and aortic arch coarctation.

A 15-year-old girl presented with upper extremity hypertension and continuous precordial murmur. Arteriography revealed aortic coarctation proximal to the origin of the left subclavian artery. An anomalous artery originated from the aortic arch, between the left common carotid artery and the stenosis. It ascended cranially and filled an angiomatous vascular formation on the left side of the neck. The "angioma" drained into the left subclavian artery. The embryological explanation of the described anomaly is difficult, but probably related to hemodynamic alterations following the prestenotic increase in blood pressure. This may have impaired the obliteration of cervical intersegmental arteries, resulting in the persistence of one of the first three intersegmental arteries as the anomalous branch of the aortic arch. The angiomatous vascular formation in the neck could be the consequence of altered development of anastomoses between the muscular twigs of both vertebral and deep cervical artery. The vessel draining the vascular formation was probably the thyrocervical trunk. Since there were no overt collateral channels or signs of left ventricular hypertrophy by electrocardiography and echocardiography, it seems that the aberrant collateral flow was hemodynamically significant and reduced the afterload on the myocardium. Although the pattern of collateral flow in our case might be considered extremely rare, it is important in preoperative planning and interpretation of imaging studies.

Adolescent↗

PubMed2001

Glycogen storage disease lb and Crohn colitis in a young woman.

The occurrence of inflammatory bowel disease in patients with glycogen storage disease lb is rare (GSD-lb). We present the case of a young woman with the diagnosis of GSD-lb Crohn-like colitis developed at age 22. Clinical evaluation revealed severe malnutrition, secondary amenorrhea, leukopenia, neutropenia, dysfunctions of phagocytosis, and subtotal stenosis of the ascending colon. Right hemicolectomy was performed and pathohistologic analysis of the resected bowel showed chronic bowel inflammation consistent with Crohn disease. Clinical status of the patient markedly improved after surgery.

Adult↗

PubMed2000

Safety of simultaneous resections of colorectal cancer and liver metastases.

Liver resection is the only potentially curative method for patients with colorectal cancer metastases and 5-year survival rates are 20%-40%. Simultaneous resection of colorectal cancer and synchronous liver metastases has been recommended if minor hepatectomy is indicated. The purpose of this paper is to analyze the treatment of hepatic colorectal secondaries and to assess the safety of simultaneous and delayed liver resections and relations of morbidity to the extensiveness of hepatectomy and perioperative factors. Analyzed were 21 patients with liver metastases from colorectal cancer operated between 1997 and 1999 in the Clinical Hospital "Sestre milosrdnice". Operating time for simultaneous colorectal and liver resections was not significantly longer compared to liver resections alone. No significant difference in complication rate was found after simultaneous procedures and liver resection alone (38% vs. 31%). Complication rate after major liver resections was not significantly greater than after minor resections (38% vs. 31%). No statistically significant differences were found in operation time and blood replacement between patients who developed postoperative complications and those who did not. In conclusion, simultaneous resections of primary colorectal cancer and liver metastases may be considered safe. Morbidity rates are not significantly different from those after liver resections alone, nor depend significantly upon the extensiveness of liver resection, providing that the operation time and blood loss are within the range observed in this study.

Adult↗

PubMed1998

Assessment of the nutritional status in Croatian pregnant women by measuring skinfolds.

In a transversal study, we assessed the changes of body composition, body weight gain, skinfold thickness and the distribution of body fat during pregnancy in 181 healthy pregnant women in Zagreb. Weight gain in pregnant women was 14.4 kg on average, out of which 5.7 kg was the total increase in body fat. In healthy pregnant women the weight gain of more than 12 kg causes excessive accumulation of body fat and has no effect on the weight of placenta and newborn. There is no significant correlation between the body weight gain of pregnant women and the weight of newborns. The increase in skinfold thickness is neither proportional nor simultaneous. Changes in biceps and triceps skinfolds indicate the dependency on the level of estrogen, and subscapular and suprailiac skinfolds on the level of progesterone in the blood of pregnant women. The index of centripetal fat pattern decreases significantly in pregnancy and is referred to peripheral redistribution of body fat in regular pregnancy. The expected weight of the newborn (eBW) may be determined by the body mass index (BMI) and triceps skinfold thickness.

Adolescent↗