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Biomedical subjects

M Korman

Publications and source records attributed to M Korman.

6 recordsLinked to original sources
PubMed1992

The long-term management of duodenal ulceration using an H2-antagonist: symptomatic self-care compared with maintenance treatment.

In a 48-week study of 319 duodenal ulcer patients, symptomatic self-care with an histamine H2-receptor antagonist (flexible self-chosen dosing with cimetidine 0, 400 or 800 mg/day) was compared with maintenance treatment (cimetidine 400 mg nocte). The rate of withdrawal from the study was similar in both groups. The mean consumption of cimetidine 400 mg tablets was significantly higher in the maintenance group (7.2 vs. 5.4 tablets/week; P less than 0.0001), but the mean cumulative number of days with ulcer symptoms was higher in the symptomatic self-care group (47.2 vs. 29.1 days in 48 weeks). The estimated number of days of work-loss due to ulcer symptoms was similar in both groups (approximately 4 days in the 48 weeks of observation). It is concluded that symptomatic self-care using an H2-antagonist can provide not only an economic but also an effective strategy for the long-term management of uncomplicated duodenal ulceration.

Adolescent↗
PubMed1979

EEG and autonomic responding to verbal, spatial and emotionally arousing tasks: differences among adults, adolescents and inhalant abusers.

The present study investigated the physiological responses of an adolescent inhalant abuse group, an adolescent non-abuse group, and an adult non-abuse group elicited by three types of tasks: verbal, spatial, and emotionally arousing. Each group consisted of 10 male Mexican-American subjects. Bilateral EEG and electrodermal activity, as well as heart rate, were monitored. While exploring for possible heart rate and hemispheric alpha wave differences in response to predominantly verbal and spatial tasks, an attempt was also made to discover if electrodermal responses could be bilaterally differentiated. Another purpose of the study was to explore possible psychophysiological differences between a younger and older group, and between an inhalant abusing group and a non-abuse group, in response to the three types of tasks. Results indicated that attempts to produce task-related EEG hemispheric asymmetry were largely nonsuccessful. Bilateral electrodermal responses were also not greatly differentiated. It was suggested that stronger task manipulations were needed. Significant group differences were found for initial physiological response levels (adults demonstrated higher levels than the two adolescent groups) and for heart rate response to the emotionally arousing task (non-abusing subjects demonstrated greater heart rate acceleration than inhalant abusing subjects). It was suggested that group differences in initial levels occurred due to the adult groups's greater involvement in the experimental situation. Heart rate differences to the emotionally arousing situation were discussed in terms of Zuckerman's sensation seeking hypothesis.

Adolescent↗
PubMed1979

Bleeding stomal ulceration.

In a prospective study of patients with haematemesis and melaena, there were 22 admissions of patients with bleeding stomal ulceration, representing 2.5% of total admissions to the Unit. In 16 patients the bleeding was from superficial stomal lesions. These lesions, endoscopically and histologically, resembled alkaline reflux gastritis, a recently defined cause of postgastrectomy bile vomiting. Five patients presented with chronic ulceration following inadequate gastric surgery. One patient was admitted on two occasions. Nine patients received more than five units of blood and came to operation for continued bleeding. In seven of the surgical cases, the bleeding was from superficial stomal lesions. Our experience suggests that truncal vagotomy is necessary to control the bleeding in these patients. One patient presented with superficial stomal ulceration and carcinomatous change. This patient died. It is important to subject these lesions to biopsy, and biopsy with extension of a previous gastrectomy is indicated to control bleeding, and to exclude malignancy.

Adult↗