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Biomedical subjects

M Korzon

Publications and source records attributed to M Korzon.

43 records · Page 3Linked to original sources
PubMedDate not supplied

Tolerance of interferon-alpha therapy in children with chronic hepatitis B.

OBJECTIVE: To assess the side-effects of interferon-alpha (IFN-alpha) therapy in children with chronic hepatitis B. METHODS: This prospective study was performed on one hundred children by interviewing the patients and their parents; clinical examinations and laboratory investigations were performed during and after therapy. RESULTS: The most frequent side-effects of IFN-alpha therapy were fever, flu-like symptoms, and headaches. Lowering of the mean haemoglobin level, leukocyte and platelet count was significant, but transient during INF-alpha treatment. No increase in autoantibody titres or significant alterations in thyroid function was observed. Twelve months after treatment, hepatitis Be antigen (HBeAg) elimination and alanine aminotransferase (ALT) normalization was achieved in 46% of the children; HBeAg and hepatatis B surface antigen (HBsAg) elimination, together with ALT normalization, was achieved in 14% of the cases. CONCLUSION: The side-effects of the IFN-alpha therapy in children such as fever, flu-like symptoms and bone marrow suppression are common, but transient and mild.

Adolescent↗
PubMedDate not supplied

Epidemiological and clinical characteristics of rotaviral diarrhoea in children from Gdańsk, Gdynia and Sopot.

The aim of the present work was to analyse clinical picture of rotaviral diarrhoea and its incidence in children from Tri-city. The study was conducted on 773 children aged 1 month-11 years, who were treated in selected hospitals in 1997 due to acute diarrhoea. Apart from physical examination and collecting patients' medical history, each child was subjected to routine laboratory investigations in accordance with clinical indications. Rotaviral aetiology of the infection was confirmed in 275 out of 773 patients with acute diarrhoea. In 80.7% cases, the disease affected children aged 7-36 months old and it was more frequent in boys than in girls. Acute diarrhoea was diagnosed mainly during cold months of the year, and the increase of its incidence was recorded between March and May. The duration of the disease usually did not exceed 3 days and its symptoms included fever, vomiting and dehydration which normally required parenteral administration of fluids. Statistical analysis was performed in order to estimate the differences in the incidence and intensity of the symptoms of rotaviral and bacterial diarrhoea. The present study showed that clinical picture of rotaviral diarrhoea in children from Tri-city was similar to that reported in literature on the subject, but there were differences regarding the seasonal occurrence of the infection which was probably related to the climate of analysed region.

Bacterial Infections↗
PubMedDate not supplied

Various types of cholestatic jaundice in infants--causes and diagnostic problems.

The purpose of this review was to evaluate possible differentiation between various causes of different types of cholestatic jaundice in children. Analyses were performed in 33 infants from 3 weeks to 3.5 years old with symptoms of cholestatic jaundice. The most frequent causes of cholestasis were congenital atresia of extrahepatic bile ducts (30%) and the CMV infection (20%). On the basis of the performed examinations it should be concluded that in order to differentiate between the causes of cholestatic jaundice it is necessary to do a series of tests as there is no specific diagnostic method which would be effective.

Bile Ducts, Extrahepatic↗
PubMedDate not supplied

Bleeding from alimentary tract in pseudo Zollinger-Ellison syndrome.

The report describes a case of a four-month-old infant, who developed acute gastric ulcer while being hospitalised because of pneumonia. One year's observation of the patient, additional tests, especially gastroscopy with histopathological evaluation of biopsy specimen, determination of gastrin level in blood serum, and therapy analysis allow to establish a diagnosis of pseudo Zollinger-Ellison syndrome.

Edema↗