PubMed Health⌕ Search

Biomedical subjects

M Kostecka

Publications and source records attributed to M Kostecka.

10 recordsLinked to original sources
PubMed2005

In vitro antifungal activity of N-3-(1,2,4-dithiazole-5-thione)-beta-resorcylcarbothioamide.

The aim of the study was the determination of antifungal activity of N-3-(1,2,4-dithiazole-5-thione)-beta-resorcylcarbothioamide (DTRTA) against Candida albicans, non-Candida albicans, dermatophytes and molds and evaluation of the enzymatic activity C. albicans strains. We used reference strains C. albicans 10231 ATCC, 200 of C. albicans strains, 7 of non-C. albicans, 12 dermatophytes strains and 20 molds strains isolated from different ontocenoses from patients. DTRTA was synthesized at Department of Chemistry University of Agriculture in Lublin was used to tests. The mean MIC of DTRTA against C. albicans strains isolated from patients was 22.01 mg/L, for reference C. albicans 10231 ATCC-- 12.5 mg/L on Sabouraud's medium (SB). The mean MIC of isolates from patients was 17.8 mg/L, and reference strains--6.25 mg/L on YNB medium, respectively. The MICs of DTRTA against 7 non-C. albicans was 33 mg/L on SB and 18.2 mg/L on YNB. The MICs of DTRTA against dermatophytes ranged from 3 to 50mg/L. The MICs of DTRTA against molds were 25 mg/L and 100 mg/L, respectively. C. albicans strains had the enzymatic activity of 16 among 19 hydrolases, after exposure to DTRTA, 15 among 19 enzymes, respectively. Non-C. albicans isolates had the enzymatic activity of 13 among 19 hydrolases, after exposure to DTRTA, 11 among 19 enzymes, respectively. This findings indicate hat DTRTA exerts a potent antifungal activity against the yeast-like fungi strains, dermatophytes and molds in vitro and.

Antifungal Agents↗
PubMed1999

The use of physical restraints in Polish psychiatric hospitals in 1989 and 1996.

The use of physical restraints in 11 locked psychiatric wards in Warsaw, Poland, was examined in 1989 and 1996 to determine whether the implementation of the Mental Health Act in 1995 and other political transformations changed this psychiatric practice. All episodes of restraint were documented during a one-month period in both years. Significantly more episodes of restraint occurred in 1996, but the average duration of each episode decreased, the number of episodes per patient fell, and the proportion of episodes due to patient aggression increased. Findings indicate that use of restraint was less arbitrary in 1996, which is likely attributable to the replacement of local institutional rules by national regulations controlling the use of restraint in psychiatric practice.

Behavior Control↗
PubMedDate not supplied

[On the need for spiritual help to patients with mental disorders].

The article presents a psychotherapeutic and spiritual approach to psychotic patients. Theoretical assumptions and a practical application (implementation and results) are described on the basis of ten years' experience with an open religious group at the Psychiatric Department of Warsaw Medical School.

Adult↗
PubMedDate not supplied

[The use of the restraint in Warsaw psychiatric hospitals before and after the introduction of the Mental Health Act].

The goal of the research was evaluation how, and to what degree the use of restraint in psychiatric hospitals was changed between 1989 and 1996. Two month observations of the 11 psychiatric wards of Warsaw psychiatric hospitals were conducted. Researchers used special questionnaire to account for all of the cases of restraint. The first research of this sort was performed in 1989, the second--in 1996. Each of the observed wards was described in terms of its conditions, equipment, personnel, the local customs and population of patients (T. Stańczak's questionnaire was used here); global level of pathology was described with the shortened version of Kellam's form. The most important difference between the characteristics of using restraint in 1996 and 1989 is the average time of remaining in restraint: it became distinctly shorter. The percentage of restraint grew after the act was issued but less patients were restrained. More often than in 1989 aggressive behaviour was the reason for restraining patients. The research clearly states that the practice of restraint was evidently modified and the freedom of its use limited. The main causes are probably the introduction of the Mental Health Act and the changes in the observed wards.

Adult↗