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Biomedical subjects

M Koulibaly

Publications and source records attributed to M Koulibaly.

At least 19 recordsLinked to original sources
PubMed2006

[Clinical and tomographic aspects of 29 cases of phakomatosis in Guinea].

The purpose of this report is to describe 29 cases of phakomatosis including 18 cases of tuberous sclerosis (Bourneville) and 11 cases of neurofibromatosis (von Recklinghausen) observed over a 10-year period at the Neurology Department of the University Hospital Centre in Conakry, Guinea. Findings during this period were consistent with those classically reported in the literature: high frequency of advanced skin lesions coalescing into massive tumours, occurrence of seizures of all types and development of a wide variety of complications as a result of late diagnosis. Our experience underscores the need for follow-up and surveillance of these patients by somatic studies based on neurological, ophthalmologic and tomographic data depending on clinical findings.

Electroencephalography↗
PubMed2001

[Anatomoclinical study of prostate benign tumors a the urology service of the CHU Ignace Deen].

OBJECTIVE: It was to compare picture and results of anatomopathological exams of the operated organs, given the individualization of new procedures in recent years. METHODS: One hundred and eighty-two patients, aged from 50 to 98 years, were hospitalized for prostatic tumors. After a complete clinical exam followed by surgery, the operated organs were the subject of a conventional histological study. Data from the rectal touch (RT) were compared with the histological results. RESULTS: In the diagnosis of benignancy, RT and the histology are in agreement in 93% of the cases, though only in 75% of the cases of suspected malignancy. Seven percent of the occult cancers are observed, of which ten cases (6%) are adenocarcinoma at Stage A, and two cases (1%) of carcinoma in situ. We observe as well one case of prostatic localization of leukemia and one case of leiomyosarcoma. Prostatitic-type inflammatory lesions and malpighian metaplasias are very frequent 18 and 7%, respectively). Basal cell hyperplasia is rare. CONCLUSION: The RT keeps its place in the exploration of the prostate, within the framework of individual screening and patient follow-up. Transrectal echography and protein-specific antigen (PSA) dosing are certainly necessary but expensive in our country. Histology, which remains irreplaceable, allows us to make a definitive diagnosis at low cost.

Adenocarcinoma↗
PubMed1999

[Aspects of genital tuberculosis in women].

Thirteen cases of genital tuberculosis are reported to make emphasis onto the difficulties of diagnosis, management and prognosis of the disease. The average age of the patients is 31 years. Most of them were under 30. The circumstances of diagnosis were variable. The diagnosis was essentially made thanks to histology. The evolution was favorable under antibiotics. But clinical sequels as amenorrhea and infertility are frequent.

Adolescent↗
PubMed1998

Differential transferrin receptor density in human colorectal cancer: A potential probe for diagnosis and therapy.

Transferrin receptor density was investigated in human colorectal surgical specimens. Crude membranes were prepared from 23 cancer tumors (adenocarcinoma or malignant villous tumor) and 3 non-cancer tumors (polyadenoma or villous tumor) and 26 adjacent control mucosa. Contrary to non-cancer tumors, Scatchard analysis of 125I-transferrin binding data evidenced higher maximal transferrin binding capacity and lower dissociation constant in cancer tissues (Bmax cancer 1.828+/-0.320 nmol/g, Kd 24.1+/-4.7 nM), as compared to paired control colonic mucosa (Bmax contol 0.851+/-0.182 nmol/g, Kd 30.7+/-7.3 nM), paired t-tests: Bmax p<0.001, Kd p<0.05). As the cancer/control Bmax ratio was 2.6+/-0.4,transferrin carrier constructs should be proposed for cancer imaging or therapy.

Adult↗
PubMed1998

[Apparently isolated case of African Burkitt lymphoma localized in the breast].

We report a case of unilateral primary Burkitt lymphoma of the breast. It occurred in a young woman with a history of recent abortion, as a painful mass confused with an abscess. The diagnostic was suggested after fine needle aspiration. Biopsy allowed confirmation, by revealing a B-phenotype lymphoma with intranuclear Epstein-virus small RNA (EBER) in all cells. Additional investigations (clinical and radiographic) were negative (no lymphadenopathy). Chemotherapy induced rapid and complete remission. Patient is in good health (no local recurrence) 5 years later.

Adult↗
PubMed1997

Cancer incidence in Conakry, Guinea: first results from the Cancer Registry 1992-1995.

We have registered 2,064 cases of cancer among the inhabitants of Conakry, Guinea, during 1992-1994, corresponding to age-standardized incidence rates (ASRs) of 83.3 per 100,000 in men and 110.5 per 100,000 in women. As elsewhere in West Africa, the principal cancer of men was liver cancer (ASR 32.6), with modest rates of stomach (ASR 6.2) and prostate (ASR 8.1) cancers. In women, cervix cancer was the dominant malignancy (ASR 46.0), followed by liver cancer (ASR 12.5) and breast cancer (ASR 10.9). In contrast to contemporary East and Central Africa, Kaposi's sarcoma remained rare (only 4 cases). In the childhood age group, relatively high incidence rates were found for Hodgkin's disease, Burkitt's lymphoma and, especially, retinoblastoma.

Adolescent↗
PubMed1990

[Peritoneal mesothelioma].

On the basis of 5 personal cases with illustrations and a review of the literature, the authors emphasize the clinicopathological features of peritoneal mesotheliomas, rare primary tumors for which the histological diagnosis is often difficult. The classical evidence by contact with asbestos fibers is obtained in every second case only. The tumor is often associated with a pleural lesion. Ultrasound and CT currently aid in the diagnosis, usually in a context of extensive ascites. The prognosis is poor. For technical reasons, surgical exeresis most often remains partial in the diffuse forms. Chemotherapy is rarely effective.

Adolescent↗
PubMed1988

[Fibroblasts of the normal human periodontium. Morphology and functional behavior in lattice collagen].

In this preliminary report, we studied human periodontal normal fibroblasts cultured on a fibrillary tridimensional net of collagen (lattice). As demonstrated by scanning and transmission electron microscope, cells were closely binded to this fibrillar net. They kept their functional activities (oxidatives enzymes, leucine aminopeptidase). As seen in monolayer cultures by immunocytochemical methods, the majority of these cells secreted type I collagen (70 to 80% of them: 15 to 25% secreting type III collagen). Besides, the capacity of retraction of collagen lattices, quite similar to that of skin lattices, was expressed by a decreasing curve up to the 8th day. In order to study the possible role of fibroblastic biological changes in periodontal disease, later on we shall compare the characteristics of normal fibroblast to those of fibroblast taken in periodontal disease.

Adult↗
PubMed1986

[Approach to age determination based on dental morphological criteria obtained in microradiography, stereomicroscopy and scanning electron microscopy].

The determination of the age owing to the morphology of permanent teeth has been done in 14 men and women, using criteria proposed by Gustafson. It was faithful, the difference between age determined by this method and the true age of these patients being never superior to 3 years. The application of scanning electron microscopy allows to improve some of the criteria used for this determination, especially that based upon the dentinal senescence.

Adult↗
PubMed1985

[Parotid sialadenosis. A histoenzymologic and ultrastructural study].

A case of sialadenosis was studied by means of several morphological methods (light microscopy with micrometric measurement, transmission and scanning electron microscopy, immunopathology, histoenzymology). In that disease, these investigations seem to corroborate the hypothesis of a dyscrinism, true perturbation of the salivary excretion with storage of secretory granules in the cells and consecutive hypertrophy. This dyscrinism should result from a deterioration of branches of autonomic nervous system. In the case reported here, no etiology was proved but the hypothetic part of a recent antiulcerous treatment by Tagamet was suggested.

Adult↗