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Biomedical subjects

M Kousa

Publications and source records attributed to M Kousa.

At least 37 records · Page 2Linked to original sources
PubMed1980

Erythema nodosum in chlamydial infections.

Twelve patients suffering from erythema nodosum who had diagnostic titres or seroconversions in chlamydial complement fixation test are described. Eleven had respiratory infections. The twelfth had sterile pyuria, symptoms of pelvic inflammatory disease and exceptionally high antibody titres against Chlamydia trachomatis in an immunofluorescence test. The simple chlamydial complement fixation test is recommended for the screening of cases of erythema nodosum.

Adolescent↗
PubMed1979

Erythromycin and lymecycline treatment in chlamydia-positive and Chlamydia-negative non-gonococcal urethritis--a partner-controlled study.

A group of 213 men with non-gonococcal urethritis and their sexual partners were treated either with erythromycin stearate 500 mgx2 for 15 days or with lymecycline 300 mgx2 for 10 or 20 days. Chlamydia trachomatis was isolated from 40% of the men, from 26% of their female partners and from 56% of the partners of men with chlamydia-positive urethritis. One hundred and eighty-one men were available for evaluation of therapy. There were no significant differences between the treatment schedules. The cure rate was 86-90% in men with chlamydia-positive and 89-100% in men with chlamydia-negative urethritis. Four of the 17 chlamydia-positive females treated with erythromycin and 2 of the 20 chlamydia-positive females treated with lymecycline for 10 days still had chlamydia at re-examination.

Chlamydia Infections↗
PubMed1977

Family study of Reiter's disease and HLA B27 distribution.

Starting from index patients with confirmed Reiter's disease, a clinical and immunogenetic study was performed on 12 families in which there were further cases of arthritis. Altogether 51 family members were investigated and some information was available on 15 additional members. In most families there were two or three affected members in addition to the proband. The manifestations included acute polyarthritis (16 cases), which frequently followed urethritis or occurred as a complication of Yersinia or Shigella infection, and chronic arthritis (9 cases), either ankylosing spondylitis or peripheral arthritis. The latter characteristically had a remitting course, affecting mainly the large joints. Not a single subject had sero-positive rheumatoid arthritis. The HLA B27 gene was detected in all 12 families, and served as the main indicator of the familial trait for developing arthritis. In individual patients however, the association was not especially close, since there were members with this antigen who did not have arthritis in spite of a seemingly adequate triggering stimulus and others who had arthritis but not the antigen.

Arthritis, Infectious↗
PubMed1976

Allergy to ingredients of vehicles.

Common ingredients of vehicles such as perfumes, antibacterial agents, emulsifiers and other surface active agents, propylene glycol, lanolin and wool alcohols were tested in eczema patients over a three-year period. Perfume allergy was detected in 3.6% of the cases, sensitivity to thiomersal in 2%, to sorbic acid in 0.8%, to parabens in only 0.3%, and to wool alcohols in 1.2%. Reactions to emulsifiers were seen over 1% of those tested.

Adult↗
PubMed1976

Contact sensitivity to emulsifiers.

Common emulsifiers were tested in over 1,200 patients with eczema. Triethanolamine stearate tested at 5% in petrolatum caused irritant reactions in 9.5% of the patients. On the other hand, non-ionic emulsifying agents tested at 10-20% produced irritation in only a few cases. Allergic reactions were found in 2.1% of those tested. Lanette, sorbitan sesquioleate, the Spans, polyoxyethylene oxypropylene stearate, polyoxyethylene sorbitol lanolin derivative, and triethanolamine stearate each elicited allergic reactions in 0.3-0.7% of the cases. The Tweens caused an allergy in only two cases, but glycerol monostearate caused no reaction at all. Five out of six patients sensitive to sorbitan sesquioleate reacted positively to the Spans as well. The patients allergic to one or more emulsifiers were also sensitive to several other substances included in our routine test series with the exception of four patients who reacted only to the emulsifying agents.

Dermatitis, Contact↗
PubMed1976

Pityriasis rubra pilaris. A clinico-pathological study with a special reference to autoradiography and histocompatibility antigens.

In a clinical study, 27 of 31 cases of pityriasis rubra pilaris (PRP) had two or more of the following clinical features: erythroderma, well-confined healthy islands inside the inflammatory areas, keratoderma of the palms and soles, or visible follicular hyperkeratosis. Histological features were: perifollicular parakeratosis in 26 cases, hyperkeratosis in 27 cases; the number of granular layers varied greatly from case to case and within one specimen; acanthosis was eczematous in 20 cases and psoriasiform in 8 cases. Erythroderma in PRP in this study was self-healing, lasting 2-6 months with one exception, but PRP must as a whole be considered a mild, chronic disease lasting on average 5.7 years. Complete recovery occurred in only 8 patients and 5 of these had had an erythrodermic onset. Serum vitamin A level and tolerance test were normal. No immunological aberrations could be found. The HLA phenotype frequencies in PRP patients did not differ significantly from those in a Finnish control population. The autoradiographic study of the epidermal cells showed an increase in the cell production in the epidermis.

Adolescent↗
PubMed1976

Psoriatic arthritis and Reiter's disease. HLA antigens in mixed cases.

HLA antigens were determined in 25 Finnish patients with both Reiter's disease and skin lesions identical with psoriasis vulgaris. HLA B27 was found in 23 cases (92%) B13 was found in one case, Bw17 and Bw37 were not found at all. The absence of these three "psoriatic" HLA antigens in the present series indicates that the psoriasis-like skin lesions belong to the varying clinical picture of Reiter's disease and not to the HLA linked psoriasis vulgaris.

ABO Blood-Group System↗
PubMedDate not supplied

Frequent association of chlamydial infection with Reiter's syndrome.

The incidence of infection with Chlamydia trachomatis in 113 men with Reiter's syndrome was investigated. Chlamydiae were isolated from urethral specimens from 40 (39%) of 103 patients and from 36 (69%) of 52 of these men who had signs of urogenital inflammation at the time of examination. Chlamydial antibodies (titers, > or = 8) were detected in sera from 66 (63%) of 104 patients by the complement-fixation test and in sera from 79 (87%) of 91 by a single-antigen indirect immunofluorescence test. Fluorescent chlamydial antibodies were found with equal frequencies in sera from patients whose cultures were negative and sera from patients whose cultures were positive, but the geometric mean titer was higher for the latter group. The results suggest that Reiter's syndrome is frequently associated with cultural and/or serologic evidence of genital infection with C. trachomatis.

Adult↗